The Practice of Additive Manufacturing for Estimation of Average Absorbed Dose in Clinical Proton Beams

Abstract: There is a necessary requirement to provide precise dosimetry measurements for radiotherapy and radiobiological studies in the proton beams. The most common practice nowadays to obtain the dose distribution is the use of ionization chambers. However, for many needs, it is also required to estimate an average absorbed dose in the target, while the targets themselves might have complex geometries and large volumes. One of the recent successful method for such measurement is the chemical dosimetry using FBX solutions coupled with the additive manufacturing, which can ensure the accurate representation of complex target geometries. In this study, we chose an optimal chemically neutral material for 3D printing that is not reacting with any of FBX compounds, manufactured the sealed waterproof target models with complex geometry and performed preliminary measurements of the average absorbed dose in a number of volumes representing the different shapes of the targets. The obtained results strongly confirm the possibility of the use of the presented technology for practical dosimetry of proton beams

RBE of "Prometeus" Facility Protons for Irradiation of Tumor Cells in vitro with One and Three Fields

The study was aimed to the biological effectiveness of the proton scanning beam of the first Russian medical facility. The clonogenic assay of B-16 tumor cells was used as a test system. Cell irradiation was carried out in a suspension condition in a water phantom. Single and three-field exposures were studied. The dose interval was 2-8 Gy. The energy range from 47.5 to 92.0 MeV was used for the Bragg peak formation. The relative biological effectiveness of protons comparing to gamma-rays was 1.2 for single-field and 1.5 for three-field irradiation. The results obtained agree with literature data related to the used cell culture (B-16) and linear energy transfer range (3÷8 keV/µm)

Calculation of the Biological Efficiency of the Proton Component from 14.8 MeV Neutron Irradiation in Computational Biology with Help of Video Cards

Fast neutron therapy, which previously has demonstrated effective results, but along with a large number of complications, can again be considered a promising treatment method in the treatment of cancer. One of the ways of analyzing the relative biological efficiency and accurate biological dose of fast neutrons in body tissues is to improve the algorithms of computational biology and mathematical modeling. A high-performance computing code was written which allows to estimate in real-time mode the biological dose of the proton component from the action of neutron radiation with an energy of 14.8 MeV. A comparative analysis of the computing performance on various video cards was also performed. © 2022, Springer Science+Business Media, LLC, part of Springer Nature