Water in Kazakhstan, a key in Central Asian water management

Abstract Central Asia is one of the regions with the highest probability of conflicts over water. Kazakhstan is the main Central Asian economic power and therefore it is important to understand how the country’s water management policy is influencing water availability in the other Central Asian states. Already, the Central Asian economies are developing under increasing water deficiency, resulting in developmental problems. The main reasons for this are increasing political tensions and worsening ecological and socio-economic conditions. Kazakhstan was the first country in Central Asia to develop the pre-requisites for a transition towards integrated water resources management (IWRM). Therefore, Kazakhstan has potential to lead the development of transboundary water integration between all Central Asian states. A scenario for successful regional cooperation on water management in Central Asia involves establishing legal mechanisms for water management following international water law, assistance by international agencies and donors, and integrated social, economic and environmental methodology

Proteomic technology for biomarker profiling in cancer: an update

The progress in the understanding of cancer progression and early detection has been slow and frustrating due to the complex multifactorial nature and heterogeneity of the cancer syndrome. To date, no effective treatment is available for advanced cancers, which remain a major cause of morbidity and mortality. Clearly, there is urgent need to unravel novel biomarkers for early detection. Most of the functional information of the cancer-associated genes resides in the proteome. The later is an exceptionally complex biological system involving several proteins that function through posttranslational modifications and dynamic intermolecular collisions with partners. These protein complexes can be regulated by signals emanating from cancer cells, their surrounding tissue microenvironment, and/or from the host. Some proteins are secreted and/or cleaved into the extracellular milieu and may represent valuable serum biomarkers for diagnosis purpose. It is estimated that the cancer proteome may include over 1.5 million proteins as a result of posttranslational processing and modifications. Such complexity clearly highlights the need for ultra-high resolution proteomic technology for robust quantitative protein measurements and data acquisition. This review is to update the current research efforts in high-resolution proteomic technology for discovery and monitoring cancer biomarkers