Self-consistency in the Projected Shell Model

The Projected Shell Model is a shell model theory built up over a deformed BCS mean field. Ground state and excited bands in even-even nuclei are obtained through diagonalization of a pairing plus quadrupole Hamiltonian in an angular momentum projected 0-, 2-, and 4-quasiparticle basis. The residual quadrupole-quadrupole interaction strength is fixed self-consistently with the deformed mean field and the pairing constants are the same used in constructing the quasiparticle basis. Taking $^{160}Dy$ as an example, we calculate low-lying states and compare them with experimental data. We exhibit the effect of changing the residual interaction strengths on the spectra. It is clearly seen that there are many $J^\pi = 0^+, 1^+, 4^+$ bandheads whose energies can only be reproduced using the self-consistent strengths. It is thus concluded that the Projected Shell Model is a model essentially with no free parameters.Comment: 13 pages, 10 figures, submitted to Nuclear Physics

Preclinical Applications of 3'-Deoxy-3'-[18F]Fluorothymidine in Oncology - A Systematic Review

The positron emission tomography (PET) tracer 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) has been proposed to measure cell proliferation non-invasively in vivo. Hence, it should provide valuable information for response assessment to tumor therapies. To date, [18F]FLT uptake has found limited use as a response biomarker in clinical trials in part because a better understanding is needed of the determinants of [18F]FLT uptake and therapy-induced changes of its retention in the tumor. In this systematic review of preclinical [18F]FLT studies, comprising 174 reports, we identify the factors governing [18F]FLT uptake in tumors, among which thymidine kinase 1 plays a primary role. The majority of publications (83 %) report that decreased [18F]FLT uptake reflects the effects of anticancer therapies. 144 times [18F]FLT uptake was related to changes in proliferation as determined by ex vivo analyses. Of these approaches, 77 % describe a positive relation, implying a good concordance of tracer accumulation and tumor biology. These preclinical data indicate that [18F]FLT uptake holds promise as an imaging biomarker for response assessment in clinical studies. Understanding of the parameters which influence cellular [18F]FLT uptake and retention as well as the mechanism of changes induced by therapy is essential for successful implementation of this PET tracer. Hence, our systematic review provides the background for the use of [18F]FLT in future clinical studies

Intellectual Control System of Processing on CNC Machines

Scientific and technical progress makes great demands for quality of engineering production. The priority is to ensure metalworking equipment with required dimensional accuracy during the entire period of operation at minimum manufacturing costs. In article considered the problem of increasing of accuracy of processing products on CNC. The authors offers a solution to the problem by providing compensating adjustment in the trajectory of the cutting tool and machining mode. The necessity of creation of mathematical models of processes behavior in an automated technological system operations (OATS). Based on the research, authors have proposed a generalized diagram of diagnosis and input operative correction and approximate mathematical models of individual processes of diagnosis

Microscopic Calculation of Total Ordinary Muon Capture Rates for Medium - Weight and Heavy Nuclei

Total Ordinary Muon Capture (OMC) rates are calculated on the basis of the Quasiparticle Random Phase Approximation for several spherical nuclei from 90^Zr to 208^Pb. It is shown that total OMC rates calculated with the free value of the axial-vector coupling constant g_A agree well with the experimental data for medium-size nuclei and exceed considerably the experimental rates for heavy nuclei. The sensitivity of theoretical OMC rates to the nuclear residual interactions is discussed.Comment: 27 pages and 3 figure

Novel Regime of Operation for Superconducting Quantum Interference Filters

A new operating regime of the Superconducting Quantum Interference Filter (SQIF) is investigated. The voltage to magnetic field response function, V(H), is determined by a Fraunhofer dependence of the critical current and magnetic flux focusing effect in Josephson junctions (F-mode). For SQIF-arrays made of high-Tc superconducting bicrystal Josephson junctions the F-mode plays a predominant role in the voltage-field response V(H). The relatively large superconducting loops of the SQIF are used for inductive coupling to the external input circuit. It is shown that the output noise of a SQIF-array measured with a cooled amplifier in the 1-2 GHz range is determined by the slope of the V(H) characteristic. Power gain and saturation power were evaluated using low frequency SQIF parameters. Finally, we consider the influence of the spread in the parameters of Josephson junctions in the SQIF-array on the V(H) characteristic of the whole structure.Comment: 7 pages, 4 figure

Partial monosomy 7q34-qter and 21pter-q22.13 due to cryptic unbalanced translocation t(7;21) but not monosomy of the whole chromosome 21: a case report plus review of the literature

<p>Abstract</p> <p>Background</p> <p>Autosomal monosomies in human are generally suggested to be incompatible with life; however, there is quite a number of cytogenetic reports describing full monosomy of one chromosome 21 in live born children. Here, we report a cytogenetically similar case associated with congenital malformation including mental retardation, motor development delay, craniofacial dysmorphism and skeletal abnormalities.</p> <p>Results</p> <p>Initially, a full monosomy of chromosome 21 was suspected as only 45 chromosomes were present. However, molecular cytogenetics revealed a de novo unbalanced translocation with a der(7)t(7;21). It turned out that the translocated part of chromosome 21 produced GTG-banding patterns similar to original ones of chromosome 7. The final karyotype was described as 45,XX,der(7)t(7;21)(q34;q22.13),-21. As a meta analysis revealed that clusters of the olfactory receptor gene family (ORF) are located in these breakpoint regions, an involvement of OFR in the rearrangement formation is discussed here.</p> <p>Conclusion</p> <p>The described clinical phenotype is comparable to previously described cases with ring chromosome 21, and a number of cases with del(7)(q34). Thus, at least a certain percentage, if not all full monosomy of chromosome 21 in live-borns are cases of unbalanced translocations involving chromosome 21.</p