Experimental study of flow past turbine blades

The requirements on gas turbines for aircraft power units, namely, adequate efficiency, operation at high gas temperatures, low weight, and small dimensions, must be taken into consideration during the design of the blading. To secure good efficiency, it is necessary that the gas flow past the blades as smoothly as possible without separation. This is relatively easily obtainable in the accelerated flow of turbine blading, if the blade spacing is chosen small enough. A small blade spacing, however, is detrimental to the other requirements outlined above. Operation at high gas temperatures usually calls for blade cooling. This cooling is associated with a power input that lowers the turbine efficiency. Since the amount of heat that must be carried off for coding a blade can be influenced rather little, the gross power input for a turbine stage can be reduced by keeping the number of blades to a minimum, that is, with blades of high spacing ratio. But here also a limit is imposed, the exceeding of which is followed by separation of flow. Hence the requirement of finding blade forms on which the flow separates at rather high spacing ratios

Increased Expression of the Auxiliary β(2)-subunit of Ventricular L-type Ca(2+) Channels Leads to Single-Channel Activity Characteristic of Heart Failure

BACKGROUND: Increased activity of single ventricular L-type Ca(2+)-channels (L-VDCC) is a hallmark in human heart failure. Recent findings suggest differential modulation by several auxiliary β-subunits as a possible explanation. METHODS AND RESULTS: By molecular and functional analyses of human and murine ventricles, we find that enhanced L-VDCC activity is accompanied by altered expression pattern of auxiliary L-VDCC β-subunit gene products. In HEK293-cells we show differential modulation of single L-VDCC activity by coexpression of several human cardiac β-subunits: Unlike β(1) or β(3) isoforms, β(2a) and β(2b) induce a high-activity channel behavior typical of failing myocytes. In accordance, β(2)-subunit mRNA and protein are up-regulated in failing human myocardium. In a model of heart failure we find that mice overexpressing the human cardiac Ca(V)1.2 also reveal increased single-channel activity and sarcolemmal β(2) expression when entering into the maladaptive stage of heart failure. Interestingly, these animals, when still young and non-failing (“Adaptive Phase”), reveal the opposite phenotype, viz : reduced single-channel activity accompanied by lowered β(2) expression. Additional evidence for the cause-effect relationship between β(2)-subunit expression and single L-VDCC activity is provided by newly engineered, double-transgenic mice bearing both constitutive Ca(V)1.2 and inducible β(2) cardiac overexpression. Here in non-failing hearts induction of β(2)-subunit overexpression mimicked the increase of single L-VDCC activity observed in murine and human chronic heart failure. CONCLUSIONS: Our study presents evidence of the pathobiochemical relevance of β(2)-subunits for the electrophysiological phenotype of cardiac L-VDCC and thus provides an explanation for the single L-VDCC gating observed in human and murine heart failure

Versuche über die Strömung durch Turbinenschaufelgitter

From Introduction: "The requirements on gas turbines for aircraft power units, namely, adequate efficiency, operation at high gas temperatures, low weight, and small dimensions, must be taken into consideration during the design of the blading. To secure good efficiency, it is necessary that the gas flow past the blades as smoothly as possible without separation. This is relatively easily obtainable in the accelerated flow of turbine blading, if the blade spacing is chosen small enough. A small blade spacing, however, is detrimental to the other requirements outlined above. Operation at high gas temperatures usually calls for blade cooling. This cooling is associated with a power input that lowers the turbine efficiency. Since the amount of heat that must be carried off for coding a blade can be influenced rather little, the gross power input for a turbine stage can be reduced by keeping the number of blades to a minimum, that is, with blades of high spacing ratio. But here also a limit is imposed, the exceeding of which is followed by separation of flow. Hence the requirement of finding blade forms on which the flow separates at rather high spacing ratios.

Design Methodology for Damage Tolerance of Composite Structures

NRC publication: Ye

A Prediction Method for the Compressive Strength of Impact Damaged Composite Laminates

NRC publication: Ye

A Prediction Method for the Compressive Strength of Impact Damaged Composite Laminates

NRC publication: Ye