Disentanglement of Topological and Dynamical Fields in 3d Higher-Spin Theory within Shifted Homotopy Approach

The first-order correction to the one-form sector of equations of the $3d$ higher-spin theory is derived from the generating nonlinear HS system by virtue of the shifted homotopy approach. The family of solutions to the generating system that disentangles equations for dynamical and topological fields in the first order of perturbation theory is found. This family is shown to belong to the different cohomology class compared to the solution found earlier by the direct methods. The related cohomology is shown to be the same as that underlying the mass deformation in the matter sector of $3d$ higher-spin equations.Comment: 21 page

ОСОБЕННОСТИ ЛИПИДНОГО И УГЛЕВОДНОГО МЕТАБОЛИЗМА ЧЕЛОВЕКА НА СЕВЕРЕ (ЛИТЕРАТУРНЫЙ ОБЗОР)

In the review the current understanding of some clinically and pathogenetically meaningful features of the lipid and carbohydrate metabolism in the indigenous and migrant population of the North and equivalent areas of Siberia are stated. Physiological and pathophysiological importance of the changes in human metabolism in the North are discussed in connection with the processes of adaptation and disadaptation to extreme climatic and geographical factors.В обзоре изложены современные представления о некоторых клинически и патогенетически значимых особенностях липидного и углеводного обменов у коренного и пришлого населения Севера и приравненных к Северу регионов Сибири. Обсуждается физиологическое и патофизиологическое значение изменений метаболизма у человека на Севере в связи с процессами адаптации и дезадаптации организма к экстремальным климато-географическим факторам

METHODOLOGICAL APPROACHES TO EVALUATING BEER AND NON-ALCOHOLIC PRODUCTS SHELF LIFE

The article discusses the relevance of developing methodological approaches to the beer and soft drinks accelerated aging method in the market. The controlled indicators selection principles, mainly affecting the quality of the finished product, and the basic equation describing the dependence of changes in indicators on the main temperature factor are given. Studies of the influence of various physical factors (temperatures in the range of 50–60 °C, UV-radiation), both individually and jointly, on the physicochemical and organoleptic characteristics of packaged water for various experimental versions did not show statistically significant changes in the normalized parameters of the basic salt and microelement composition investigated water during storage. The optimal mode of accelerated «aging» of packaged water at an elevated temperature (up to 60 °C) and UV-radiation was established. In the case of soft drinks, thermostating was used when changing the temperature regimes (heat 50 ± 2 °C / cold 6 ± 2 °C) at an exposure time of 30 days, which made it possible to observe a decrease in taste and aroma compared with the control, as well as a decrease in sweetness and the appearance of a slight plastic taste for non-carbonated drink. The influence a temperature regime change on brewing products, which cannot be estimated using the existing method due to the high turbidity, is shown.The article discusses the relevance of developing methodological approaches to the beer and soft drinks accelerated aging method in the market. The controlled indicators selection principles, mainly affecting the quality of the finished product, and the basic equation describing the dependence of changes in indicators on the main temperature factor are given. Studies of the influence of various physical factors (temperatures in the range of 50–60 °C, UV-radiation), both individually and jointly, on the physicochemical and organoleptic characteristics of packaged water for various experimental versions did not show statistically significant changes in the normalized parameters of the basic salt and microelement composition investigated water during storage. The optimal mode of accelerated «aging» of packaged water at an elevated temperature (up to 60 °C) and UV-radiation was established. In the case of soft drinks, thermostating was used when changing the temperature regimes (heat 50 ± 2 °C / cold 6 ± 2 °C) at an exposure time of 30 days, which made it possible to observe a decrease in taste and aroma compared with the control, as well as a decrease in sweetness and the appearance of a slight plastic taste for non-carbonated drink. The influence a temperature regime change on brewing products, which cannot be estimated using the existing method due to the high turbidity, is shown

C-reactive protein as an indicator of polymorbidity in patients with arterial hypertension

Aim of the study was to investigate the role of C-reactive protein as an indicator of multimorbidity in patients with arterial hypertension.Material and methods. A retrospective archival study of the data of 1958 patients with arterial hypertension who were examined and treated at the clinic of the Federal Research Center for Fundamental and Translational Medicine (Novosibirsk) was carried out. 2 groups of patients were allocated depending on the concentration of C-reactive protein in the blood serum: normal and elevated (> 5 mg/l). A comparative analysis of the severity of polymorbidity, as well as clinical, laboratory and biochemical parameters in the selected groups were carried out.Results. It has been established that patients with arterial hypertension with elevated values of C-reactive protein had higher rates of transnosological and transsystemic polymorbidity, accompanied by changes in lipid, carbohydrate and purine metabolism (a decrease in high-density lipoprotein cholesterol, an increase in the concentration of glucose and uric acid in blood serum, an increase in the index atherogenicity), as well as an increase in the content of fibrinogen in the blood serum.Conclusions. The concentration of C-reactive protein in the blood serum can serve as a biochemical marker of polymorbidity in patients with arterial hypertension

Complications after BCG vaccination in a big city

Complications after specific prevention of tuberculosis for the last 10 years have been analyzed using the example of a big city. The frequency of severe complications (BCG-ostitis) made 0.004% and the frequency of minor complications (lymphadenitis) made 0.005% and cold abscesses made 0.01% per 100 000 vaccinated children. Often complications were caused by mistakes in the vaccine administration related to premature discharge from maternity hospital and administration of the vaccine in the polyclinic and also concurrent prenatal disorder. The issue of complications caused by anti-tuberculosis vaccination makes no grounds to review the policy of the primary BCG vaccination

Prognostic value of molecules of average mass in patients with chronic obstructive pulmonary disease

Background. Chronic obstructive pulmonary disease is a socially significant disease affecting patient’s quality of life. Assessment of endogenous intoxication in patients with chronic obstructive pulmonary disease will allow to understand pathogenetic features of different phenotypes of this disease, which can be taken into account when predicting its course.The aim of the study. To determine the prognostic value of levels of mediumand low-molecular-weight substances and oligopeptides in patients with chronic obstructive pulmonary disease.Materials and methods. One hundred and four patients with chronic obstructive pulmonary disease (COPD) and 110 somatically healthy individuals were examined. Molecular weight medium and low molecular weight substances (LMWSM) and oligopeptides (OP) were determined in blood plasma, erythrocytes and urine. Based on these indicators mathematically calculated indices of endogenous intoxication and coefficient of elimination were defined. Statistical processing of the data was performed using the SPSS 26.0 software package (IBM Corp., USA).Results. In all biological fluids, the levels of average molecules and calculated indices in the COPD patients’ group were statistically significantly different from those in the control group. The indices characterizing endotoxin accumulation were statistically significantly higher, while those characterizing toxin elimination were lower. The level of endotoxemia was correlated with the frequency of exacerbations, clinical manifestations severity, quality of life, COPD group and phenotype.Conclusions. Frequent exacerbations, groups C and D, bronchitic and mixed COPD phenotypes are characterized by more severe endotoxicosis manifested by high levels of LMWSM, OP and calculated indices

Risk factors in patients with non-alcoholic fatty liver disease associated with arterial hypertension, overweight and obesity

Purpose of the study was to investigate the features of the occurrence of risk factors in patients with non-alcoholic fatty liver disease associated with arterial hypertension, overweight and obesity.Material and methods. The object of the study was the data of 14 393 case histories of patients with arterial hypertension (AH), non-alcoholic fatty liver disease (NFLD), overweight body (OB) and obesity, examined and treated at the clinic of the Federal Research Center forFundamental and Translational Medicine (Novosibirsk).Results and discussion. Features of biochemical parameters in patients with NFLD with AH, OB and obesity were studied in comparison with patients with isolated diseases. It was shown that in patients, in case of the presence of this comorbidity, the value of transsystem polymorbidity is statistically significantly increased compared with groups of patients with isolated diseases. It was established that patients with concomitant diseases have higher, statistically significant values of systolic and diastolic blood pressure, body mass index. They have higher concentrations of total cholesterol, triglycerides, high density lipoprotein cholesterol, glucose, uric acid in the blood serum, higher atherogenic index. A study of the frequency of occurrence of risk factors in the groups showed the highest frequency values in patients with associated diseases: high blood pressure, dyslipidemia, hypertriglyceridemia, hypercholesterolemia, hypoalphacholesterolemia, hyperlipidemia, increased atherogenic index, hyperglycemia, hyperuricemia, the higher levels of C-reactive protein, which indicates that with associated pathology, changes in carbohydrate, lipid and purine metabolism are more pronounced. These changes are factors that aggravate the course of the pathology and are risk factors for the development of diabetes mellitus, atherosclerosis and associated conditions, which requires a personalized approach to the treatment and prevention of this category of patients. The results of this study can form the basis for the development of new medical technology for assessing the severity of condition in patients with non-alcoholic fatty liver disease combined with arterial hypertension, overweight and obesity

Diagnostic value of structural and functional changes in the carotid and vertebral arteries in arterial hypertension, associated with benign paroxysmal positional vertigo

Objective of the study was to assess the diagnostic significance of hemodynamic disorders in the area of carotid and vertebral arteries in patients with hypertension combined with benign paroxysmal positional vertigo (DPPG) using ultrasound duplex scanning of neck vessels.Material and methods. Thirty eight patients of the clinic of Federal Research Center for Fundamental and Translational Medicine with hypertension and concomitant dizziness were examined. The state of carotid and vertebral arteries, blood flow in the arteries were assessed by duplex ultrasound scanning using the Vivid E9 apparatus.Results and discussion. The influence of the blood flow at the level of carotid and vertebral arteries on the severity of clinical symptoms of dizziness in patients with hypertension with concomitant DPPG was shown. The clinical significance of atherosclerotic changes in carotid arteries, tortuosity of carotid and vertebral arteries of the effectiveness of treatment and prevention of dizziness in patients with hypertension and DPPG was revealed. It is shown that in patients with hypertension and comorbid DPP, the severity of the relationship of hemodynamically significant changes in the carotid and vertebral arteries with clinical manifestations of dizziness is greater than in patients with hypertension without DPP. The use of ultrasound duplex scanning of brachiocephalic arteries in hypertension with comorbid vertigo allows for differential diagnosis of benign paroxysmal positional vertigo and cerebrovascular dyscirculatory disorders, the degree of their participation in clinical manifestations of dizziness. A new medical technology for the diagnosis of pathogenic mechanisms of dizziness in patients with hypertension, using ultrasound duplex scanning of carotid and vertebral arteries, allows to personalize treatment and prevention in such patients

IN SITU VASCULAR TISSUE REMODELING USING BIODEGRADABLE TUBULAR SCAFFOLDS WITH INCORPORATED GROWTH FACTORS AND CHEMOATTRACTANT MOLECULES

Background Currently, the search for the bioactive molecules capable of promoting formation of the vascular tissue is still ongoing. We have previously demonstrated that incorporation of the growth factors and chemoattractant molecules into the biodegradable tubular scaffolds can increase their primary patency upon the implantation into rat abdominal aorta. However, further studies are required to investigate tissue remodeling using functionalized vascular grafts with the same diameter as a replaced native vessel. Aim To investigate the specific aspects of de novo vascular tissue formation and calcification employing rat abdominal aorta interposition model and vascular grafts with 1.5 mm diameter with incorporated vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and stromal cell-derived factor (SDF)-1α. Methods Tubular grafts with a diameter of 1.5 mm were blended of poly(3-hydroxybutyrateco-3-hydroxyvalerate) and poly(ε-caprolactone) (PHBV/PCL). Grafts without growth factors were fabricated using standard electrospinning technique whilst grafts with incorporated growth factors were prepared utilizing emulsion electrospinning. VEGF was incorporated into the inner third, whereas bFGF and SDF-1α were incorporated into the outer two-thirds of the graft. Grafts were implanted into the abdominal aortas of Wistar rats for 1, 3, 6, and 12 months following scanning electron microscopy along with histological and immunofluorescent examination. Results Primary patency of the grafts with VEGF, bFGF, and SDF-1α reached 93% indicative of structural integrity of the vascular tissue. Neither signs of inflammation nor severe calcification was detected. Conclusion As in 2 mm diameter vascular grafts, incorporation of bioactive factors into 1.5 mm diameter grafts increased their long-term primary patency and improved vascular tissue formation in comparison with non-modified grafts.  Background Currently, the search for the bioactive molecules capable of promoting formation of the vascular tissue is still ongoing. We have previously demonstrated that incorporation of the growth factors and chemoattractant molecules into the biodegradable tubular scaffolds can increase their primary patency upon the implantation into rat abdominal aorta. However, further studies are required to investigate tissue remodeling using functionalized vascular grafts with the same diameter as a replaced native vessel. Aim To investigate the specific aspects of de novo vascular tissue formation and calcification employing rat abdominal aorta interposition model and vascular grafts with 1.5 mm diameter with incorporated vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and stromal cell-derived factor (SDF)-1α. Methods Tubular grafts with a diameter of 1.5 mm were blended of poly(3-hydroxybutyrateco-3-hydroxyvalerate) and poly(ε-caprolactone) (PHBV/PCL). Grafts without growth factors were fabricated using standard electrospinning technique whilst grafts with incorporated growth factors were prepared utilizing emulsion electrospinning. VEGF was incorporated into the inner third, whereas bFGF and SDF-1α were incorporated into the outer two-thirds of the graft. Grafts were implanted into the abdominal aortas of Wistar rats for 1, 3, 6, and 12 months following scanning electron microscopy along with histological and immunofluorescent examination. Results Primary patency of the grafts with VEGF, bFGF, and SDF-1α reached 93% indicative of structural integrity of the vascular tissue. Neither signs of inflammation nor severe calcification was detected. Conclusion As in 2 mm diameter vascular grafts, incorporation of bioactive factors into 1.5 mm diameter grafts increased their long-term primary patency and improved vascular tissue formation in comparison with non-modified grafts