Measuring system for testing electrical parameters of EMCCDs of various formats

This article describes the developed equipment that allows measuring the photoelectrical parameters of multielement photodetectors, specifically various formats of EMCCD (electron multiplying charge-coupled device) chips. The authors present the measuring techniques and test results on dark currents, output amplifier sensitivity, charge transfer efficiency, charge capacity and other parameters. The studies were conducted, both on the wafer and in the body, on samples of the following formats: 576×288, 640×512, 768×576, 1024×1024, and 1280×1024.В данной статье описывается разработанное оборудование, позволяющее измерять фотоэлектрические параметры многоэлементных фотоприемников, в частности, различных форматов микросхем ПЗСЭУ (приборы с зарядовой связью и электронным умножением). Представляны методы измерения и результаты испытаний на темновые токи, чувствительность выходного усилителя, эффективность переноса заряда, зарядную емкость и другие параметры. Исследования проводились на образцах следующих форматов: 576×288, 640×512, 768×576, 1024×1024 и 1280×1024, как на пластине, так и в корпусе.В даній статті описано розроблену вимірювальну систему, що дозволяє досліджувати фотоелектричні параметри багатоелементних фотоприймачів, зокрема ПЗЗЕМ різних форматів. Представлено методики та результати вимірювань темнових струмів, чутливості вихідного підсилювача, ефективності передачі заряду, зарядової ємності та інших параметрів. Дослідження проводилися на зразках формату 576×288, 640×512, 768×576, 1024×1024, 1280×1024 як на пластинах, так і в корпусах

Methods of creation of intellectual knowledge evaluation system, students in natural language

This article provides a framework for the design and development of intelligent information system of knowledge evaluation using an open form tasks, the “open” (without variants of answers) test tasks are considered as efective. Student’s answer entered in a free form gives an opportunity to present student’s views on the subject more accurately. And we evaluate his knowledge, and not based on a guessed answer to the question, which proves the efectiveness of the proposed method. This article presents an approach for text analysis in natural language and organization of query in the knowledge based on the ontology

СЕМАНТИЧЕСКИЕ ТЕХНОЛОГИИ ПРОЕКТИРОВАНИЯ ИНТЕЛЛЕКТУАЛЬНЫХ СИСТЕМ И СЕМАНТИЧЕСКИЕ АССОЦИАТИВНЫЕ КОМПЬЮТЕРЫ

The analysys of the problem of ensuring compatibility of computer systems was carried out. The basic principles underlying the OSTIS technology, one of the tasks of which is the solution of this problem was discussed. Special attention is paid to the principles of semantic associative computers construction, which are the hardware basis for the interpretation of systems developed on the basis of this technology.В статье проведен анализ проблемы обеспечения совместимости компьютерных систем, рассмотрены основные принципы, лежащие в основе технологии OSTIS, одной из задач которой является решение данной проблемы. Отдельное внимание уделено принципам построения семантических ассоциативных компьютеров, являющихся аппаратной реализацией интерпретатора логико-семантических моделей компьютерных систем, разрабатываемых по технологии OSTIS

Semantic technologies of intelligent systems design and semantic associative computers

В статье проведен анализ проблемы обеспечения совместимости компьютерных систем, рассмотрены основные принципы, лежащие в основе технологии OSTIS, одной из задач которой является решение данной проблемы. Отдельное внимание уделено принципам построения семантических ассоциативных компьютеров, являющихся аппаратной реализацией интерпретатора логико-семантических моделей компьютерных систем, разрабатываемых по технологии OSTIS.The analysys of the problem of ensuring compatibility of computer systems was carried out. The basic principles underlying the OSTIS technology, one of the tasks of which is the solution of this problem was discussed. Special attention is paid to the principles of semantic associative computers construction, which are the hardware basis for the interpretation of systems developed on the basis of this technology

Sub-THz nonresonant detection in AlGaN/GaN heterojunction FETs

Abstract. Un-cooled AlGaN/GaN-based heterojunction field-effect transistors (HFET) designed on sapphire (0001) substrates were considered as 140 GHz direct detection detectors without any specially attached antennas. The noise equivalent power (NEP) of these detectors was ~

Chronic Myeloid Leukemia Patient Registry in the Russian Federation: From Observational Studies to the Efficacy Evaluation in Clinical Practice

Background. Due to the significant increase in life expectancy and the quality of life in patients with chronic myeloid leukemia (CML) as well as the growing need for expensive tyrosine kinase inhibitors (TKI), the analysis of cost-effectiveness and lifelong monitoring of patients is especially important. Aim. We present the results of a multicenter observational study “The Russian Registry of Chronic Myeloid Leukemia in routine clinical practice (2011–2016)”. Materials & Methods. The study included Russian patients with CML, confirmed by the detection of a Ph-chromosome or a BCR-ABL transcript. The statistical analysis (July 1, 2016) included 7609 patients from 80 regions of the Russian Federation (covering 95 % of the population). The annual increase in the number of patients with newly diagnosed CML was 600–650 patients. At the time of the statistical analysis, 6995 (92 %) patients remained under observation, 473 (6 %) died and 141 (2 %) were withdrawn. The registry included 44 % of men and 56 % of women, the median age was 49 years (range 2–94 years). The peak incidence (46.3 %) occurred at the age of 40–60 years. The median disease duration by the time of the analysis was 6 years (range 0.1–30 years). Results. The disease was diagnosed in the chronic phase (CP), acceleration phase, and blast crisis in 6560 (93.8 %), 380 (5.5 %) and 47 (0.7 %) patients, respectively. The proportion of risk groups according to Sokal for low, intermediate and high risk in CP was 49 %, 30 %, and 21 %, respectively. TKI were administered to 6473 (92.5 %) patients. Imatinib and the second generation TKI (TKI2) were administered to 5570 (86 %) and 903 (14 %) patients, respectively. The total of 30.4 % of patients received the increased imatinib dose of 600–800 mg. In the TKI2 group, 558 (61.7 %) patients received nilotinib and 345 (38.2 %) patients received dasatinib. The proportion of patients with completed molecular genetic studies (MGS) in 2014, 2015 and the first 6 months of 2016 amounted to 61 %, 58 % and 23 %, respectively. The proportion of patients with cytogenetic studies (CS) for the same period was 28 %, 26 % and 7 %, respectively. No CS or MGS data were presented for 34 %, 35 % and 63 % of patients during this period. Optimal molecular response and major molecular response (MMR) for TKI therapy were observed in 23 % and 58 % of patients treated 12 months, respectively. When nilotinib was used in the second line, MMR was obtained in 42 % of patients, and a deep molecular response was obtained in 25 % of patients (BCR-ABL < 0.01 %). Conclusion. The high efficacy of TKI therapy was observed in the majority of patients with the possibility of achieving a minimal residual disease. The problems concerning untimely monitoring and suboptimal administration of second line treatment were identified. In general, the CML patient registry allowed the data integration of data and information management of population with CML in Russia

Интеллектуальные компьютерные системы нового поколения и технология комплексной поддержки их жизненного цикла

The paper considers the principles of building next-generation intelligent computer systems, as well as the principles of building a comprehensive technology for their development and life cycle support - OSTIS Technology. Semantic compatibility and interoperability are highlighted as the key properties of the next-generation intelligent systems. The paper considers an approach to providing these properties, realized within the framework of OSTIS Technology

Statistical modeling of the mother-baby system in newborn infants with cerebral ischemia

The statistical model could consider the influence of specific maternal psychoemotional and personality factors on a newborn with cerebral ischemia and develop a procedure to prevent negative consequences of postpartum depression in the mother-baby system

Основные направления, проблемы и перспективы развития интеллектуальных компьютерных систем нового поколения и соответствующей им технологии

The paper considers the main directions, problems, and prospects for the development of nextgeneration intelligent computer systems and corresponding technologies, with a focus on the current state of work in the field of Artificial Intelligence. It highlights the problems and methodological challenges of the current stage of development, as well as the prerequisites for transitioning to intelligent computer systems of the new generation. The text also provides background and history of OSTIS Technology development, and outlines its features, advantages, and novelty. Additionally, it mentions current projects related to the development of OSTIS Technology in the current stage of work