Search for solar axions produced by Compton process and bremsstrahlung using the resonant absorption and axioelectric effect

The search for resonant absorption of Compton and bremsstrahlung solar axions by $^{169}$Tm nuclei have been performed. Such an absorption should lead to the excitation of low-lying nuclear energy level: $A+^{169}$Tm $\rightarrow ^{169}$Tm$^*$ $\rightarrow ^{169}$Tm $+ \gamma$ (8.41 keV). Additionally the axio-electric effect in silicon atoms is sought. The axions are detected using a Si(Li) detectors placed in a low-background setup. As a result, a new model independent restrictions on the axion-electron and the axion-nucleon coupling: $g_{Ae}\times|g^0_{AN}+ g^3_{AN}|\leq 2.1\times10^{-14}$ and the axion-electron coupling constant: $|g_{Ae}| \leq 2.2\times 10^{-10}$ has been obtained. The limits leads to the bounds $m_{A}\leq$ 7.9 eV and $m_{A}\leq$ 1.3 keV for the mass of the axion in the DFSZ and KSVZ models, respectively ($90\%$ C.L.).Comment: 6 pages, 3 figures, contributed to the 9th Patras Workshop on Axions, WIMPs and WISPs, Mainz, June 24-28, 201

Malignant hyperthermia: current approaches to prevention and treatment

One of the most serious complications of modern anesthesia is malignant hyperthermia, which is a pharmacogenetic disease phenotype manifested by skeletal muscle hypermetabolism and rhabdomyolysis during or after general anesthesia with the use of inhaled anesthetics and succinylcholine. In Russia, the problem of malignant hyperthermia remains unresolved. This is mainly due to the fact that the only specific drug dantrolene created for the effective treatment of malignant hyperthermia is still not legalized and thus formally prohibited to import, disseminate and apply on the domestic pharmaceutical market. This article deals with the regulatory framework of specific treatment of malignant hyperthermia in Russia, allowing the possibility to legally import to the territory of the Russian Federation dantrolene as an unregistered drug, if it is a question of rendering medical assistance on vital indications to a particular patient, or its unauthorized use for vital indications in a situation of extreme necessity. The article presents the recommendations of domestic experts on the treatment of malignant hyperthermia. In this case, as a possible alternative to dantrolene, magnesium preparations are considered, whose role in the treatment of the crisis of malignant hyperthermia continues to be specified. Thus, given the increasing use of inhalation anesthesia by Russian anesthetists, to ensure the safety of patients with regard to the development of malignant hyperthermia, it is possible only in the case of official registration in the domestic dantrolene market. Also, in the territory of Russia, a network of relevant consultative and diagnostic centers should be established. These measures will undoubtedly increase the effectiveness of treatment and prevention of severe consequences of this disease in our country

New limit on the mass of 9.4-keV solar axions emitted in an M1 transition in 83^{83}Kr nuclei

A search for resonant absorption of the solar axion by $^{83}\rm{Kr}$ nuclei was performed using the proportional counter installed inside the low-background setup at the Baksan Neutrino Observatory. The obtained model independent upper limit on the combination of isoscalar and isovector axion-nucleon couplings $|g_3-g_0|\leq 1.69\times 10^{-6}$ allowed us to set the new upper limit on the hadronic axion mass of $m_{A}\leq 130$ eV (95\% C.L.) with the generally accepted values $S$=0.5 and $z$=0.56.Comment: 5 pages, 2 figures, Proceedings of the 10th Patras Workshop on Axions, WIMPs and WISP 29 June - 4 July 2014, CERN, Geneva, Switzerlan

Constraints on the axion-electron coupling for solar axions produced by Compton process and bremsstrahlung

The search for solar axions produced by Compton ($\gamma+e^-\rightarrow e^-+A$) and bremsstrahlung-like ($e^-+Z \rightarrow Z+e^-+A$) processes has been performed. The axion flux in the both cases depends on the axion-electron coupling constant. The resonant excitation of low-lying nuclear level of $^{169}\rm{Tm}$ was looked for: $A+^{169}$Tm $\rightarrow ^{169}$Tm$^*$ $\rightarrow ^{169}$Tm $+ \gamma$ (8.41 keV). The Si(Li) detector and $^{169}$Tm target installed inside the low-background setup were used to detect 8.41 keV $\gamma$-rays. As a result, a new model independent restriction on the axion-electron and the axion-nucleon couplings was obtained: $g_{Ae}\times|g^0_{AN}+ g^3_{AN}|\leq 2.1\times10^{-14}$. In model of hadronic axion this restriction corresponds to the upper limit on the axion-electron coupling and on the axion mass $g_{Ae}\times m_A\leq3.1\times10^{-7}$ eV (90% c.l.). The limits on axion mass are $m_A\leq$ 105 eV and $m_A\leq$ 1.3 keV for DFSZ- and KSVZ-axion models, correspondingly (90% c.l.).Comment: 7 pages, 4 figure

Влияние различных методов седации у больных с острой тяжелой черепно-мозговой травмой на перекисное окисление липидов

Objective: to study the impact of various sedation methods on lipid peroxidation in patients with acute severe brain injury. Subjects and methods. For this, 44 victims with this condition were examined. According the option of posttraumatic sedation therapy, the victims were divided into 3 groups: 1) 12 patients in whom sodium oxybutyrate was used for sedation; 2) 12 received thiopental sodium; 3) 20 patients were given propofol. The lipid peroxidation and antioxidant system were judged from the serum levels of fatty acid hydroperoxides and secondary lipid peroxidation products (malonic dialdehyde) and from the content of the endogenous antioxidant a-tocopherol. Results. The study performed indicated that the highest concentrations of fatty acid hydroperoxides were observed in Groups 1 and 2 within the first 24 posttraumatic hours. In Group 3 where propofol was used for sedation, the concentration of the hydroperoxides remained in the normal range although there was a tendency for their rise. Conclusion. Thus, propofol is the agent of choice for sedation that prevents the activation of lipid peroxidation and stabilizes some indices of the antioxidant system in patients with acute severe brain injury. Key words: brain injury, lipid peroxidation, sedation, sodium oxybutyrate, thiopental sodium, propofol.Цель исследования — изучить влияние различных методов седации у больных с острой тяжелой черепно-мозговой травмой на перекисное окисление липидов. Материал и методы. Для достижения указанной цели обследованы 44 пострадавших с острой тяжелой черепно-мозговой травмой. В зависимости от вида седационной терапии, проводившейся в посттравматическом периоде, больные были разделены на 3 группы. В I группу (12 чел.) вошли больные, которым с целью седации использовался оксибутират натрия, во II группе (12 чел.) больных применялся тиопентал натрия, и в III группе больных (20 чел.) вводился пропофол. О состоянии перекисного окисления липидов и антиоксидантной системы судили по уровню в сыворотке крови гидроперекисей жирных кислот и вторичных продуктов перекисного окисления липидов — малонового диальдегида, содержанию эндогенного антиоксиданта альфа-токоферола. Результаты. Проведенное исследование показало, что в 1-е сутки посттравматического периода наиболее высокие концентрации гидроперекисей жирных кислот отмечались в I и II группах больных. В III же группе больных, где для седации использовался пропофол, концентрация гидроперекисей оставались в пределах нормальных значений, хотя также оставалась тенденция к их росту. Заключение. Таким образом, наиболее благоприятным вариантом седации, предупреждающей активацию перекисного окисления липидов и стабилизирующей некоторые показатели антиоксидантной системы у больных с острой тяжелой черепно-мозговой травмой является пропофол. Ключевые слова: черепно-мозговая травма, перекисное окисление липидов, седация, оксибутират натрия, тиопентал натрия, пропофол