Decentralized control of thermostatic loads for flexible demand response

Thermostatically controlled loads (TCLs), such as refrigerators, air-conditioners and space heaters, offer significant potential for short-term modulation of their aggregate power consumption. This ability can be used in principle to provide frequency response services, but controlling a multitude of devices to provide a measured collective response has proven to be challenging. Many controller implementations struggle to manage simultaneously the short-term response and the long-term payback, whereas others rely on a real-time command-and-control infrastructure to resolve this issue. In this paper, we propose a novel approach to the control of TCLs that allows for accurate modulation of the aggregate power consumption of a large collection of appliances through stochastic control. By construction, the control scheme is well suited for decentralized implementation, and allows each appliance to enforce strict temperature limits. We also present a particular implementation that results in analytically tractable solutions both for the global response and for the device-level control actions. Computer simulations demonstrate the ability of the controller to modulate the power consumption of a population of heterogeneous appliances according to a reference power profile. Finally, envelope constraints are established for the collective demand response flexibility of a heterogeneous set of TCLs

Frequency control using thermal loads under the proposed ENTSO-E Demand Connection Code

© 2015 IEEE.Thermal loads such as refrigerators and electric space heaters use temperature hysteresis controllers that are insensitive to small temperature fluctuations. This results in an ability to modulate their power consumption, thus providing cost-effective frequency support, balancing services and energy arbitrage. In order to partially realise these benefits, ENTSO-E has proposed a mandatory frequency support service for thermal loads in its Network Code on Demand Connection. This is to be implemented as a proportional shift of the setpoint temperature in accordance with frequency deviations. In this paper we argue that this implementation choice results in an unpredictable response that depends strongly on controller details. Furthermore, it restricts the flexibility to implement advanced controllers that deliver multiple services simultaneously. We present a case study that demonstrates very different frequency response patterns from three controllers that are each compatible with the proposed Code. Alternative implementations of the code and controllers are presented to illustrate the scope for improvement

Stochastic scheduling with inertia-dependent fast frequency response requirements

High penetration of wind generation will increase the requirement for fast frequency response services as currently wind plants do not provide inertial response. Although the importance of inertia reduction has been widely recognized, its impact on the system scheduling has not been fully investigated. In this context, this paper proposes a novel mixed integer linear programming (MILP) formulation for stochastic unit commitment that optimizes system operation by simultaneously scheduling energy production, standing/spinning reserves and inertia-dependent fast frequency response in light of uncertainties associated with wind production and generation outages. Post-fault dynamic frequency requirements, rate of change of frequency, frequency nadir and quasi-steady-state frequency are formulated as MILP constraints by using the simplified model of system dynamics. Moreover the proposed methodology enables the impact of wind uncertainty on system inertia to be considered. Case studies are carried out on the 2030 Great Britain system to demonstrate the importance of incorporating inertia-dependent fast frequency response in the stochastic scheduling and to indicate the potential for the proposed model to inform reviews of grid codes associated with fast frequency response and future development of inertia-related market

Intumescent flame retardant properties of graft co-polymerized vinyl monomers onto cotton fabric

In this paper, an intumescent flame retardant treatment, obtained by a combination of vinylphosphonic acid (VPA) and methacrylamide (MAA), was applied to cotton fabrics. In order to improve the cross-linking degree onto cellulose polymers, potassium persulfate was used as initiator of a radical polymerization technique. The application on cotton was carried out by padding, followed by drying and a curing treatment. The treated samples were characterized by SEM, TGA and FTIR-ATR analyses and tested in terms of flammability and washing fastness. The thermal and fire behavior of the treated fabrics was thoroughly investigated. The results clearly showed that the VPA/MAA coating was able to exert a protective action, giving rise to the formation of a stable char on the surface of textile fibers upon heating, hence improving the flame retardant performance of cotton. Horizontal flame spread tests confirmed that the coated fabrics achieved self-extinction, and the residues well preserved the original weave structure and fiber morphology ; at variance, the uncoated fabric left only ashes. A remarkable weight loss was observed only after the first washing cycle, then the samples did not show any significant weight loss, hence confirming the durability of the self-extinguishing treatment, even after five laundering cycles

Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain

Calcium sensing receptor (CaSR), isolated for the first time from bovine and human parathyroid, is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expression in neurons and oligodendrocytes, whereas it was not found expressed both in the microglia and in astrocytes. One week after kainate-induced seizure CaSR was found in the injured CA3 region of the hippocampus and very interestingly it was found up-regulated in the neurons of CA1-CA2 and dentate gyrus. Similarly, 1 week following ibotenic acid injection in the hippocampus, CaSR mRNA expression was increased in oligodendrocytes both in the lesioned area and in the contralateral CA1-CA3 pyramidal cell layers and dentate gyrus. One week after needle-induced mechanical lesion an increase of labeled cells expressing CaSR mRNA was observed along the needle track. In conclusion, the present results contribute to extend available data on cell type-expressing CaSR in normal and injured brain and could spur to understand the role of CaSR in repairing processes of brain injury

MIRU-VNTR genotyping of Mycobacterium tuberculosis strains using QIAxcel technology: a multicentre evaluation study

Molecular genotyping of M.tuberculosis is an important laboratory tool in the context of emerging drug resistant TB. The standard 24-loci MIRU-VNTR typing includes PCR amplification followed by the detection and sizing of PCR fragments using capillary electrophoresis on automated sequencers or using agarose gels. The QIAxcel Advanced system might offer a cost-effective medium-throughput alternative.Performance characteristics of the QIAxcel Advanced platform for the standard 24 VNTR loci panel was evaluated at two centres on a total of 140 DNA specimens using automated capillary electrophoresis as a reference method. Additionally 4 hypervariable MIRU-VNTR loci were evaluated on 53 crude DNA extracts. The sizing accuracy, interlaboratory reproducibility and overall instrument's performance were assessed during the study.An overall concordance with the reference method was high reaching 98.5% and 97.6% for diluted genomic and crude DNA extracts respectively. 91.4% of all discrepancies were observed in fragments longer than 700bp. The concordance for hypervariable loci was lower except for locus 4120 (96.2%). The interlaboratory reproducibility agreement rates were 98.9% and 91.3% for standard and hypervariable loci, respectively. Overall performance of the QIAxcel platform for M.tuberculosis genotyping using a panel of standard loci is comparable to that of established methods for PCR fragments up to 700bp. Inaccuracies in sizing of longer fragments could be resolved through using in-house size markers or introduction of offset values. To conclude, the QiaXcel system could be considered an effective alternative to existing methods in smaller reference and regional laboratories offering good performance and shorter turnaround times

Growth hormone-releasing hormone attenuates cardiac hypertrophy and improves heart function in pressure overload-induced heart failure

It has been shown that growth hormone-releasing hormone (GHRH) reduces cardiomyocyte (CM) apoptosis, prevents ischemia/reperfusion injury, and improves cardiac function in ischemic rat hearts. However, it is still not known whether GHRH would be beneficial for life-threatening pathological conditions, like cardiac hypertrophy and heart failure (HF). Thus, we tested the myocardial therapeutic potential of GHRH stimulation in vitro and in vivo, using GHRH or its agonistic analog MR-409. We show that in vitro, GHRH(1-44)NH2attenuates phenylephrine-induced hypertrophy in H9c2 cardiac cells, adult rat ventricular myocytes, and human induced pluripotent stem cell-derived CMs, decreasing expression of hypertrophic genes and regulating hypertrophic pathways. Underlying mechanisms included blockade of Gq signaling and its downstream components phospholipase Cβ, protein kinase Ce, calcineurin, and phospholamban. The receptor-dependent effects of GHRH also involved activation of Gαsand cAMP/PKA, and inhibition of increase in exchange protein directly activated by cAMP1 (Epac1). In vivo, MR-409 mitigated cardiac hypertrophy in mice subjected to transverse aortic constriction and improved cardiac function. Moreover, CMs isolated from transverse aortic constriction mice treated with MR-409 showed improved contractility and reversal of sarcolemmal structure. Overall, these results identify GHRH as an antihypertrophic regulator, underlying its therapeutic potential for HF, and suggest possible beneficial use of its analogs for treatment of pathological cardiac hypertrophy

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