Diagnostics and correction of metabolic disorders in patients with recurrent urolithiasis after endoscopic removal of stones

The article is devoted to the problem of kidney stones. The authors provide the results of a study of 107 men aged 48 to 76 years, were divided into three groups – primary and two control groups. The main and the first control group consisted of 40 patients with recurrent urolithiasis without urinary tract obstruction after endoscopic stone removal and partial androgen deficiency. The second control group consisted of 27 healthy men aged 48 to 70 years. Patients for one year he was promoted endoscopic removal of urinary stones: transurethral nephrolithotripsy – 55 patients, and percutaneous nephrolithotripsy – 25. After discharge from hospital all patients had a diagnosis and correction of metabolic disorders using physical-chemical and biochemical indicators of urine and blood. To study the mineral composition and structural-textural features of urinary stones and their fragments after surgical interventions were performed: x-ray diffraction, infrared spectroscopy, polarization and electron microscopy. Was carried out following the relapse of urolithiasis: patients of the main group received pathogenetic androgen therapy as monotherapy, and patients in the control group conventional treatment (antibiotics, spasmolytic, herbal remedies). The results of therapy and follow-up care for 6 years showed a low recurrence of stone formation in patients of the main group and highest in the control. Age-related decline in androgen levels in men may be an additional factor in stone formation. Pathogenic androgen replacement therapy leads to normalization of the content of lithogenic substances in the blood and urine, as well as physico-chemical properties of urine, thereby reducing the process of stone formation

РОЛЬ ПЕДАГОГИЧЕСКОЙ И КЛИНИЧЕСКОЙ ПРОФИЛАКТИКИ СТОМАТОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ У СТАРШИХ ДОШКОЛЬНИКОВ В УСЛОВИЯХ ДОУ

A study of 19 preschool children (8 ofthem with speech disorders, 19 parents, 4 preschool teacher were to identify low hygienic knowledge and skills of parents and children. Children in violation of the formation of speech found in the playback lag motor tasks on the space-time parameters, broke a sequence of elements of action, lowered its component parts, the longer formulated phrase. What to consider when creating training programs for oral health.В результате исследования 19 детей старшего дошкольного возраста (из них 8 с речевыми расстройствами; 19 родителей, 4 воспитателя ДОУ были выявление низкие гигиенические знания и навыки у родителей и детей. Дети с нарушением формирования речи обнаружили отставание в воспроизведении двигательного задания по пространственно-временным параметрам, нарушали последовательность элементов действия, опускали его составные части, дольше формулировали фразы. Что следует учитывать при создании программ обучения гигиене полости рта

The course of complicated chronic pyelonephritis during intercurrent disease. Diagnosis and treatment

The aim of the research is to study the clinical and biochemical, immunological indicators in dynamics of treatment of complicated chronic pyelonephritis during intercurrent diseases. The conducted researches showed that metabolic changes in this patients are characterized by structural and functional instability of cytomembranes and reduction of immunological resistance of organism. The additional insertion of antioxidant therapy in standard scheme of treatment is substantiated by the results of clinical and biochemical, immunological research.Целью исследования стало изучение клинико-биохимических и иммунологических показателей в динамике лечения осложненного хронического пиелонефрита на фоне интеркуррентных заболеваний. Проведенные исследования показали, что метаболические изменения у таких больных характеризуются структурно-функциональной нестабильностью цитомембран и снижением иммунологической резистентности организма. результатами клинико-биохимического и иммунологического обследования обосновано дополнительное введение в стандартную схему лечения антиоксидантной озонотерапии и препаратов с иммуномодулирующими свойствами

Eczema: tactics of choice external therapy

The therapeutic effects of synthetic tannins are based on their binding action, as well as on their anti-pruritic, antimicrobial and anti-inflammatory effects. Materials and methods. A clinical study of Neotanin spray, Neotanin lotion (suspension) and Neotanin cream was carried out in 8 clinical centres during the period from June, 2017 to January, 2018. The study had an open and non-comparative character. The study included 68 patients of both sex es aged from 1 month to 80 years suffering from eczema dermatosis in the acute weeping phase, including cases with complications after secondary infections (including eczema elements localized on the face). Before the study, information on the clinical history, demographic data, co-morbidities, physical examination data of the patients was collected. The treatment regimen included 2 stages: 1) Neotanin in the spray or lotion (suspension) form 3–4 times per day during 1–5 days, up to the full drying of eczema elements; 2) Neotanin in the cream form 3 times per day, up to the disappearance of the clinical manifestations of skin dermatosis. The duration of the study ranged from 5 to 14 days: the study was completed when a patient had achieved remission. The criteria for assessing the drug efficacy were as follows: dynamics of subjective complaints, objective assessment of the patient's condition (the presence and severity of clinical symptoms), dynamics of the Dermatology Life Quality Index (DLQI). Results. Neotanin preparations showed a high efficacy in the acute and subacute stages of the inflammatory process as an antipruritic agent. Itching stopped within 5 minutes after the drug application, with the antipruritic effect lasting for an average of 3–4 hours. In 85 % of the patients, marked excoriations were absent on the 3rd day of treatment. Neotanin demonstrated a pronounced anti-inflammatory effect. In 92 % of the patients, the symptoms of erythema and edema were significantly reduced one week after the beginning of treatment, with the manifestations of inflammatory exudation being conclusively decreased. One week following the beginning of treatment, 100 % of the patients demonstrated no oozing lesions. The absence of serious undesirable effects in the patients during the study evidences to the good tolerability and safety of this drug

ЭФФЕКТИВНОСТЬ ЗОЛЕДРОНОВОЙ КИСЛОТЫ В ПРОФИЛАКТИКЕ КОСТНЫХ МЕТАСТАЗОВ У ПАЦИЕНТОВ С МЕСТНО-РАСПРОСТРАНЕННЫМ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

The analysis of the performed study has established that zoledronic acid is an effective agent in multimodality therapy for locally advanced prostate cancer (PC) and allows long-term stabilization of bone tissue. In addition, there is evidence for the efficacy of zoledronic acid in preventing bone metastases (BM) and increasing the time to the first BM. The currently accumulated experience with zoledronic acid used in PC permits one to consider its use as standard concomitant therapy.На основании анализа проведенного исследования установлено, что золедроновая кислота является эффективным препаратом в комплексной терапии местно-распространенного рака предстательной железы (РПЖ) и позволяет стабилизировать в течение длительного времени состояние костной ткани. Кроме того, подтверждена эффективность золедроновой кислоты в профилактике костных метастазов (КМ), а также в увеличении времени до появления первого КМ. Накопленный к настоящему времени опыт использования золедроновой кислоты при РПЖ позволяет рассматривать ее назначение как стандартную сопроводительную терапию

Necessary and sufficient conditions for the boundedness of the Riesz potential in local Morrey-type spaces

This paper deals with the boundedness of the Riesz potential in local and global Morrey-type spaces. We obtain an estimate for the Lp norm of the Riesz potential over a ball, which is used to reduce this problem to the boundedness of a Hardy operator in weighted Lp spaces on a half-line on the cone of nonnegative nonincreasing functions. This makes it possible to derive sufficient conditions for the boundedness of the Riesz potential for all admissible parameter values. For local Morrey-type spaces, these sufficient conditions are also necessary under certain relations between the parameters