Prevention and control of noncommunicable diseases role of family physicians in improving compliance to lifestyle modification

Noncommunicable diseases (NCDs) like diabetes and cardiovascular disease have already overtaken communicable diseases in terms of mortality and morbidity in India. NCDs thus pose a serious economic threat to developing countries and can have a marked impact on the quality-of-life of affected individuals. In the management of NCDs like diabetes or hypertension, lifestyle (i.e.: nondrug) measures are of paramount importance for therapy to be successful. These nondrug measures include decreasing physical inactivity, eating a healthy diet, stress management, avoidance of tobacco products, moderation in alcohol intake and most importantly increased awareness about the condition. In India, as in most parts of the world, patients usually tend to consult their Family Physician (FP) first. Although most FPs are aware of the benefits of nondrug measures, they seldom spent time on assessing patient's physical activity, diet and stress levels or even educating the patient about the same. This paper reviews and discusses different means by which the FPs can improve patient compliance to nondrug measures in the prevention and control of NCDs

The TOC-ABC choice debate for product mix decisions : introducing asset specificity as an alternate explanation

Though constructed with different purposes, the theory of constraints and activity based costing systems pose a choice problem in respect of product mix decisions. We believe that the existing explanation of short versus long run criterion to explain firms\u27 choice between these two systems is incomplete and offer an alternate explanation based on asset specificity. We argue that the extent to which specialized resources are deployed to make products in a mix determines the choice. We present a 2*2 matrix stating that when asset specificity is high, a firm is likely to choose ABC instead of TOC since ABC makes a large portion of costs visible to enable control. However, the choice is likely to be a TOC-ABC combination when the manufacture of asset specific products is also constrained by bottlenecks.<br /

INSILICO DOCKING STUDIES TO IDENTIFY POTENT INHIBITORS OF ALPHA-SYNUCLEIN AGGREGATION IN PARKINSON DISEASE

Background: Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Etiology of PD is progressive loss of dopaminergic neurons in Substantia nigra pars compacta (SNpc). One of the pathological hallmarks of PD is the presence of intracellular proteinaceous substances termed ‘Lewy bodies' composed of aggregated alpha-synuclein which is responsible for its toxic effect on SNpc. Hence any therapeutic target which blocks α-synuclein aggregation will provide a new channel to cure PD. Objective: The aim of the present study is to identify potent inhibitors (ligands) which binds to active site of α-synuclein and prevents self-association. Methods: In this study, insilico molecular docking was done against α-synuclein using five plant derived compounds namely (a) stimovul (b) 7,8dihydroxycoumarin, (c) etorphine (d) propoxyphene and (e) pentazdine. These compounds were analyzed for their Lipinski and ADMET properties using Accelrys Discovery studio 3.5. Molecular docking was performed between ligand and protein using Lead IT. Results: Results revealed that the best fit ligands against active site of α-synuclein were identified as Stimovul with a docking score of -4.5122 and the interacting amino acids were found to be SER 87 and VAL 95 followed by other compounds. Conclusion: These compounds which have the ability to bind to α-Synuclein insilico can be further developed using invitro and in vivo studies as a potent anti-parkinson drug.Â&nbsp;Â&nbsp; Keywords: Parkinson disease, Substantia nigra, Molecular docking, Lipinski, ADMET

Periodic Quasi - Exactly Solvable Models

Various quasi-exact solvability conditions, involving the parameters of the periodic associated Lam{\'e} potential, are shown to emerge naturally in the quantum Hamilton-Jacobi approach. It is found that, the intrinsic nonlinearity of the Riccati type quantum Hamilton-Jacobi equation is primarily responsible for the surprisingly large number of allowed solvability conditions in the associated Lam{\'e} case. We also study the singularity structure of the quantum momentum function, which yields the band edge eigenvalues and eigenfunctions.Comment: 11 pages, 5 table

Dynamic Interface to Enhance Network Efficiency Using Channel Allocation

Abstract--Wireless Sensor Networks (WSN) is a group of spatially dispersed and dedicated sensors for monitoring and recording the physical conditions of the environment and organizing the collected data at a central location. The sensor nodes are extraordinarily limited in resources, so the important aim of designing routing protocol of WSN is to improve the routing efficiency and maximize the lifetime of networks. In the recent past, the routing efficiency and its issues can be solved by various protocols. In this paper we enhanced many to one transmission with AODV protocol and efficient channel allocation. We have implemented flat multi-hop routing algorithms which enable routing of data in a fashion that minimizes the power consumption of the WSN they fail to exploit the data aggregation opportunities by virtue of data collected from the WSN. In many WSN applications with the relatively high node density, the data collected by individual nodes are highly redundant, thus making data aggregation a very attractive scheme in WSNs. Hybrid multi-hop routing algorithms aim to capitalize on the highly correlated nature of WSN&apos;s collected data. It can improve the routing efficiency and channel allocation in cluster networks. The cluster head selection is obtained based on energy level and routing efficiency of the network

Mycobacteremia in tuberculosis patients with HIV infection

Background: Mycobacteremia in HIV positive tuberculosis patients is associated with extra-pulmonary tuberculosis and disseminated tuberculosis. Objective: To study the occurrence of mycobacteremia among HIV-infected patients with tuberculosis (both pulmonary and extra-pulmonary forms) using radiometric BACTEC method. Methods: HIV positive patients admitted to the Government Hospital of Thoracic Medicine with a clinical diagnosis of tuberculosis were screened. HIV serology was reconfirmed using ELISA (two different tests) at Tuberculosis Research Centre. Five ml of venous blood was collected on the day of admission to the ward before start of anti-tuberculosis therapy. Results: Of the 105 patients screened, 85 were were found to be eligible for analysis. Patients were aged between 20-40 years, with a male preponderance (5:1). Pulmonary tuberculosis was the predominant form of tuberculosis (85%), while 15 % had associated extra-pulmonary involvement. Eight-four percent of the patients had CD4 counts of less than 200 cells/mm3, with 42% being below 50 cells/mm3. Four of the 85 patients were blood culture positive; three were identified as M.tuberculosis and one as Mycobacterium phlei. Conclusions: Mycobacteremia was detected in 4% of HIV positive patients with tuberculosis. All of them were immunosuppressed with CD4 counts of <50 cells/m3. More work needs to be done in India to understand the risk factors and outcome of patients with mycobacteremia

Electronic structure of and Quantum size effect in III-V and II-VI semiconducting nanocrystals using a realistic tight binding approach

We analyze the electronic structure of group III-V semiconductors obtained within full potential linearized augmented plane wave (FP-LAPW) method and arrive at a realistic and minimal tight-binding model, parameterized to provide an accurate description of both valence and conduction bands. It is shown that cation sp3 - anion sp3d5 basis along with the next nearest neighbor model for hopping interactions is sufficient to describe the electronic structure of these systems over a wide energy range, obviating the use of any fictitious s* orbital, employed previously. Similar analyses were also performed for the II-VI semiconductors, using the more accurate FP-LAPW method compared to previous approaches, in order to enhance reliability of the parameter values. Using these parameters, we calculate the electronic structure of III-V and II-VI nanocrystals in real space with sizes ranging upto about 7 nm in diameter, establishing a quantitatively accurate description of the band-gap variation with sizes for the various nanocrystals by comparing with available experimental results from the literature.Comment: 28 pages, 8 figures, Accepted for publication in Phys. Rev.