Features of treatment of patients with psoriasis with metabolic syndrome

The article provides information on the prevalence of metabolic syndrome in patients with psoriasis. The criteria for the diagnosis of metabolic syndrome are presented. The General mechanisms of inflam - mation development in psoriasis and diseases forming the metabolic syndrome are described. Systemic subclinical inflammatory process developing in psoriasis and metabolic syndrome is considered as the main pathogenetic mechanism of their mutual negative influence. The difficulties of treatment of patients with psoriasis with metabolic syndrome are largely associated with the choice of a safe and effective method of treatment. The description of the drug apremilast (OTEZLA®) is a selective inhibitor of the enzyme phosphodiesterase 4, which may be the best drug in the therapy of patients with psoriasis and metabolic syndrome

ETIOPATHOGENETIC THERAPY OF INFLAMMATORY DERMATOSES

In chronic dermatoses significantly increases the colonization of skin by bacteria and fungi, which can have a negative impact on the course of inflammatory process. Cream Candiderm is a modern combined topical drug that has anti-inflammatory, antibacterial and antifungal activity.The aim of the study was to assess the efficacy, safety and tolerability of the cream Candiderm in the treatment of patients with eczema and atopic dermatitis.Material and methods. 37 patients with AD and 28 patients with eczema. Applied cream Candiderm 2 times a day, which was applied to the affected area of the skin. Before and on the 14 day of therapy was conducted bacteriological examination of the microflora of the skin rashes.Results: at 14 days in patients with eczema remission was achieved in 17 (61 %) patients, significant improvement 6 (21 %), improvement in 4 (14 %), lack of effect in 1 (4 %); in patients with AD remission was observed in 23 (62 %) patients, significant improvement in 7 (19 %), and improvement in 5 (14 %), lack of effect in 2 (5 %).Conclusions: high clinical efficacy of the cream of Candiderm allows recommending it for topical therapy of patients with eczema and atopic dermatitis

Free association experiment in determining the gender characteristics in the understanding of the concept "мong" by the speakers of Tatar linguistic culture

The relevance stated in the article the problem is due to the fact that the study of key concepts of the cultures is in recent times one of the dominant positions within the framework of the problem of interaction and mutual influence of language and cultureand the results of mass association experiment ongender-specificby the speakers of Tatar Linguistic Culture. The article includes the study of main characteristics of the concept "Моң" [moŋ] (lyrical sadness, melody) as an emotional concept in the Tatar language picture of the world and its derivations. The purpose of the study is to examine the representation of linguistic-cultural concept in the Tatar national-cultural picture of the world by means of mass associative experiment that extends the knowledge about the specifics of the Tatar mentality. The choice of methods of linguoculturological analysis, including the observation of language material and the description of linguistic facts, the method of analysis of dictionary definitions, etymological, contextual and interpretative analyses, structural-semantic modeling of lexical units, statistical method for processing language material, the associative interrogation of informants, due to the specifics of the studied material,that allow us to thoroughly review and analyze the studied concept. The analysis of the linguistic-cultural concept allows revealing the peculiarities of development of national and linguistic consciousness, to fix the reflection on the verbal level of cogitative activity of the Tatar people, the specifics of his mental world. The results of mass associative experiment can contribute to further study of the culturally significant concepts of the Tatar language picture of the world.Keywords and phrases: education, student. Concept, linguoculturological field, Linguisticculturology, language picture of the world, the association, a mass association experimen

Spatial Structure of Triglycine Determined by the Residual Dipolar Coupling Analysis

The possibility to determine the relatively small organic compound conformations by the approach on the basis of the analysis of the residual dipolar couplings 1H-13C in the molecules partially aligned in lyotropic liquid crystalline media has been considered. This approach has been used in the nuclear magnetic resonance investigation of the triglycine structure in lyotropic medium (cetylpyridinium bromide/n-hexanol). The conformation of triglycine in solution has been established as trans-trans on the basis of the experimental data of observed couplings

Psoriatic onychodystrophy: clinical manifestations (part 1)

Psoriatic onychodystrophy is quite common in patients with psoriasis. Changes in psoriatic nails have a wide range of clinical manifestations, including symptoms of damage of the nail bed and/or nail matrix. The article presents information about clinical and pathological manifestations of psoriatic onychodystrophy, the mechanisms of formation of pathological changes. The existence of the relationship between the change of nail plates in patients with psoriasis and the development of psoriatic arthritis is explained, the prognostic value of individual symptoms is analyzed. The diagnostic criteria for the histological diagnosis of psoriatic onychodystrophy are described. The information about the occurrence of each symptom in patients with psoriasis with dystrophic nail changes is given

Geometric structure of 2-phenyl-1,3-dithia-5,6-benzocycloheptene 1-oxide

Two-dimensional nuclear Overhauser effect spectroscopy (2D NOESY) was used to determine proton-proton distances for the chair conformer of 2-phenyl-1,3-dithia-5,6-benzocycloheptene 1-oxide in CD2Cl2 in the system CS2-CDCl3. Changing the solvent by a more polar changes the molecular conformation. As a result, the dipole moment may also be affected, and this should be taken into account in analysis of solvent effects on thermodynamic parameters of the conformational equilibrium

The features of the language of representation of humour in the texts of American and Russian stand-up comedians

Based on the definition of the research object and the subject of sociolinguistics, which is considered an independent scientific discipline, in this article we assume to study the features of the language representation and perception of humour in performances of stand-up comedians from American and Russian linguocultures. We will also consider the similarities and differences of the topics of the texts of American and Russian comedians. In consideration of the genre of special interest is the attitude of the audience (in fact - the society) to the obscene and non-obscene language ("black humor"; "jokes below the belt", etc.) used by stand-up comedians in their performances in the United States and Russia. The relevance of this study is related to the overall underexplored genre"standup" fromlinguistics point of view and originality of their language. Research methodology –set of methods of textual, contextual, linguistic and linguostylistic analysis of the content of the texts of public performances ofthe comedians in the United States and Russia. Material for the study consists of texts of performances of stand-up comedians. The results of our research will help to identify the specifics of the language means of representation of humour in the texts of stand-up comedians.Key words: text, research, speech, language, translation, humour, linguistics, linguoculture,sociolinguistics

Separation of Cross-Relaxation and Exchange in Two-Site Spin Systems with Weak Spin-Spin Couplings

A ratio relating the cross-relaxation rates, rate constants, and cross-peak and diagonal peak integrals is used for the analysis of exchanging two-site spin systems with weak scalar spin-spin couplings to extract the rate constants and cross-relaxation rates contributing to the same cross-peaks in two-dimensional nuclear Overhauser enhancement spectra (2-D NOESY). The method to separate contributions from cross-relaxation and chemical exchange into the cross-peaks in NOESY spectra was applied to investigate the intramolecular dynamics of trisulfide 4H,8H-naphtho[1,8-ef]1,2,3-trithiocine in solutions

Separation of cross-relaxation and exchange in two-site spin systems without resolved couplings

Variable temperature two-dimensional nuclear Overhauser enhancement experiment (2-D NOESY) is used to extract the rate constants and cross-relaxation rates that contribute to the same cross-peaks in NOESY spectra. Rate constants (kAB) and cross-relaxation rates (RAB) for two-site spin systems are related to the ratio between the cross-peak and diagonal peak integrals (F) by the expression: RAB - kAB = (1/2 τm)1n[(1 - F)/(1 + F)], where τm is the mixing time. As a model, we investigated the exchange processes in a system of dimer calix[4]arenes of C4v symmetrical configuration with guest inclusion (benzene or benzene-d6), where the measurement of exchange processes is hindered by the presence of strong nuclear Overhauser enhancement between protons in adjacent aromatic rings in the cone conformation of the calix[4]arene

Spatial Structure of Dimeric Capsules of Tetraurea Calix[4]arenes in Solutions According to 2-D NMR (NOESY) Spectroscopy

Spatial structure of calixarene has been investigated by two-dimensional nuclear magnetic resonance (nuclear Overhauser effect) spectroscopy. Interproton distances for the given compound in solutions of benzene and cyclohexane have been measured and the experimental values have been compared with theoretically predicted ones