Combined frequency-amplitude nonlinear modulation: theory and applications

In this work we formulate a generalized theoretical model to describe the nonlinear dynamics observed in combined frequency-amplitude modulators whose characteristic parameters exhibit a nonlinear dependence on the input modulating signal. The derived analytical solution may give a satisfactory explanation of recent laboratory observations on magnetic spin-transfer oscillators and fully agrees with results of micromagnetic calculations. Since the theory has been developed independently of the mechanism causing the nonlinearities, it may encompass the description of modulation processes of any physical nature, a promising feature for potential applications in the field of communication systems.Comment: 8 pages, 4 figures, to be published on IEEE Transactions on Magnetic

Statistics of Entropy Production in Linearized Stochastic System

We consider a wide class of linear stochastic problems driven off the equilibrium by a multiplicative asymmetric force. The force brakes detailed balance, maintained otherwise, thus producing entropy. The large deviation function of the entropy production in the system is calculated explicitly. The general result is illustrated using an example of a polymer immersed in a gradient flow and subject to thermal fluctuations.Comment: 4 pages, 1 figur

Electrically tunable detector of THz-frequency signals based on an antiferromagnet

A concept of an electrically tunable resonance detector of THz-frequency signals based on antiferromagnetic/heavy metal (AFM/HM) hetero-structure is proposed. The conversion of a THz-frequency input signal into DC voltage is done using the inverse spin Hall effect in an (AFM/HM) bilayer. An additional bias DC current in the HM layer can be used to vary the effective anisotropy of the AFM, and, therefore, to tune the AFMR frequency. The proposed AFM/HM hetero-structure works as a resonance-type quadratic detector which can be tuned by the bias current in the range of at least 10 percent of the AFMR frequency and our estimations show that the sensitivity of this detector could be comparable to that of modern detectors based on the Schottky, Gunn or graphene-based diodes

Therapeutic sequences in patients with grade 1−2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group

Purpose: Many different treatments are suggested by guidelines to treat grade 1−2 (G1−G2) neuroendocrine tumors (NET). However, a precise therapeutic algorithm has not yet been established. This study aims at identifying and comparing the main therapeutic sequences in G1−G2 NET. Methods: A retrospective observational Italian multicenter study was designed to collect data on therapeutic sequences in NET. Median progression-free survival (PFS) was compared between therapeutic sequences, as well as the number and grade of side effects and the rate of dose reduction/treatment discontinuation. Results: Among 1182 patients with neuroendocrine neoplasia included in the ELIOS database, 131 G1–G2 gastroenteropancreatic, lung and unknown primary NET, unresectable or persistent/relapsing after surgery, treated with ≥2 systemic treatments, were included. Four main therapeutic sequences were identified in 99 patients: (A) somatostatin analogs (SSA) standard dose to SSA high dose (n = 36), (B) SSA to everolimus (n = 31), (C) SSA to chemotherapy (n = 17), (D) SSA to peptide receptor radionuclide therapy (PRRT) (n = 15). Median PFS of the second-line treatment was not reached in sequence A, 33 months in sequence B, 20 months in sequence C, 30 months in sequence D (p = 0.16). Both total number and severity of side effects were significantly higher in sequences B and C than A and D (p = 0.04), as well as the rate of dose reduction/discontinuation (p = 0.03). Conclusions: SSA followed by SSA high dose, everolimus, chemotherapy or PRRT represent the main therapeutic sequences in G1−G2 NET. Median PFS was not significantly different between sequences. However, the sequences with SSA high dose or PRRT seem to be better tolerated than sequences with everolimus or chemotherapy

Scalable synchronization of spin-Hall oscillators in out-of-plane field

A strategy for a scalable synchronization of an array of spin-Hall oscillators (SHOs) is illustrated. In detail, we present micromagnetic simulations of two and five SHOs realized by means of couples of triangular golden contacts on the top of a Pt/CoFeB/Ta trilayer. Results highlight that the synchronization occurs for the whole current region that gives rise to the excitation of self-oscillations. This is linked to the role of the magnetodipolar coupling, which is the phenomenon driving the synchronization when the distance between oscillators is not too large. Synchronization turns out to be also robust against geometrical differences of the contacts, simulated by considering variable distances between the tips ranging from 100nm to 200nm. Besides, it entails an enlargement of the radiation pattern that can be useful for the generation of spin-waves in magnonics applications. Simulations performed to study the effect of the interfacial Dzyaloshinskii-Moriya interaction show nonreciprocity in spatial propagation of the synchronized spin-wave. The simplicity of the geometry and the robustness of the achieved synchronization make this design of array of SHOs scalable for a larger number of synchronized oscillators

Spin-Hall nano-oscillator with oblique magnetization and Dzyaloshinskii-Moriya interaction as generator of skyrmions and nonreciprocal spin-waves

Spin-Hall oscillators are promising sources of spin-wave signals for magnonics applications, and can serve as building blocks for magnonic logic in ultralow power computation devices. Here, we analytically and micromagnetically study magnetization dynamics excited in a Spin-Hall oscillator with oblique magnetization when the spin-Hall effect and interfacial Dzyaloshinskii-Moriya interaction act simultaneously. Our key results are (i) excitation of nonreciprocal spin-waves propagating perpendicularly to the in-plane projection of the static magnetization, (ii) skyrmions generation by pure spin-current, (iii) excitation of a new spin-wave mode with a spiral spatial profile originating from a gyrotropic rotation of a dynamical skyrmion. These results demonstrate that Spin-Hall oscillators can be used as generators of magnetic skyrmions and different types of propagating spin-waves for magnetic data storage and signal processing applications