ПРИНЦИПИ КОНСТРУКЦІЇ З НАВІГАЦІЙНО-ПРИЗЕМЛЕНОЮ СИСТЕМОЮ ДЛЯ ЛІТАКІВ МІСЦЕВИХ АВІАЛІНІЙ

The variants of construction and use of surface and side radio equipment are considered in the article, the indexes of quality of the system are certain, priorities are placed for its different modifications.В статье рассмотрены варианты построения и использования систем  наземного и бортового радиооборудования, расставлены приоритеты для различных ее модификаций.У статті розглянуті варіанти побудови і використання наземного і бортового радіоустаткування системи, розставлені пріоритети для різних її модифікацій

The lightest scalar glueball

Recently performed investigations of meson spectra allow us to determine the resonance structure for the waves $IJ^{PC}=00^{++}$, $10^{++}$, $02^{++}$, $12^{++}$ = $IJ^P= 1/2 0^+$ in the mass region up to 1900 MeV, thus establishing the meson multiplets $1^3P_0q\bar q$ and $2^3P_0q\bar q$. Experimental data demonstrate that there are five scalar/isoscalar states in this mass region. Four of them are $q\bar q$ states, that is, members of the $1^3P_0q\bar q$ and $2^3P_0q\bar q$ nonets, while the fifth state is an extra one not accomodated by $q \bar q$ systematics; it has the properties of the lightest scalar glueball. Analysis of the $00^{++}$-wave performed within the framework of the dispersion relation technique allows us to reconstruct the mixing of a pure gluonium with neighbouring scalar $q \bar q$ states belonging to $1^3P_0q\bar q$ and $2^3P_0q\bar q$ nonets: three scalar mesons share the gluonium state between each other -- those are two comparatively narrow resonances $f_0(1300)$ and $f_0(1500)$ and a broad resonance $f_0(1530^{+90}_{-250})$. The broad state is a descendant of the gluonium, keeping about 40-50% of its component.Comment: 48 pages, LaTeX, 25 PostScript figures, epsfig.sty. Submitted to Russian Journal Uspekhi Fiz. Nauk (Phys-Uspekhi

An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci

A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event models. A multivariate form of the reduction principle is found: reduction results at individual loci combine topologically to produce a surface of mutation rate alterations that are neutral for a new modifier allele. New mutation rates survive if and only if they fall below this surface - a generalization of the hyperplane found by Zhivotovsky et al. (1994) for a multilocus recombination modifier. Increases in mutation rates at some loci may evolve if compensated for by decreases at other loci. The strength of selection on the modifier scales in proportion to the number of germline cell divisions, and increases with the number of loci affected. Loci that do not make a difference to marginal fitnesses at equilibrium are not subject to the reduction principle, and under fine tuning of mutation rates would be expected to have higher mutation rates than loci in mutation-selection balance. Other results include the nonexistence of 'viability analogous, Hardy-Weinberg' modifier polymorphisms under multiplicative mutation, and the sufficiency of average transmission rates to encapsulate the effect of modifier polymorphisms on the transmission of loci under selection. A conjecture is offered regarding situations, like recombination in the presence of mutation, that exhibit departures from the reduction principle. Constraints for tractability are: tight linkage of all loci, initial fixation at the modifier locus, and mutation distributions comprising transition probabilities of reversible Markov chains.Comment: v3: Final corrections. v2: Revised title, reworked and expanded introductory and discussion sections, added corollaries, new results on modifier polymorphisms, minor corrections. 49 pages, 64 reference

Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling

Research on existing drugs often discovers novel mechanisms of their action and leads to the expansion of their therapeutic scope and subsequent remarketing. The Wnt signaling pathway is of the immediate therapeutic relevance, as it plays critical roles in cancer development and progression. However, drugs which disrupt this pathway are unavailable despite the high demand. Here we report an attempt to identify antagonists of the Wnt-FZD interaction among the library of the FDA-approved drugs. We performed an in silico screening which brought up several potential antagonists of the ligand-receptor interaction. 14 of these substances were tested using the TopFlash luciferase reporter assay and four of them identified as active and specific inhibitors of the Wnt3a-induced signaling. However, further analysis through GTP-binding and β-catenin stabilization assays showed that the compounds do not target the Wnt-FZD pair, but inhibit the signaling at downstream levels. We further describe the previously unknown inhibitory activity of an anti-leprosy drug clofazimine in the Wnt pathway and provide data demonstrating its efficiency in suppressing growth of Wnt-dependent triple-negative breast cancer cells. These data provide a basis for further investigations of the efficiency of clofazimine in treatment of Wnt-dependent cancers. © 2013 Elsevier Inc

Моделирование аппаратно-алгоритмической структуры мобильной многопозиционной радиодальномерной навигационно-посадочной аэросистемы в её пространственных конфигурациях

The concept of structuring of radio equipment, mathematical and algorithmic tools to provide computing operations for determining the location of aircraft in spatial configuration of mobile (portable) multipositioning radio rangefinding interrogation-reply navigation and landing system is considered in this article. The mathematical modeling of algorithms of aircraft traffic terminal control is carried out. The results of calculations of potential system performance and its analysis for compliance with international safety requirements are represented.В статье рассмотрена концепция структурирования радиоаппаратных, математических и алгоритмических средств в обеспечении вычислительных операций по определению местоположения воздушных судов в пространственных конфигурациях мобильной (переносной) многопозиционной радиодальномерной запросно-ответной навигационно-посадочной системы. Проведено математическое моделирование алгоритмов терминального управления движением летательных аппаратов. Представлены результаты расчетов потенциальных характеристик системы и их анализа на соответствие международным требованиям по безопасности полетов

Сравнительная оценка стандартного эхокардиографического исследования и классификационной модели на основе параметров функциональной геометрии левого желудочка в диагностике систолической дисфункции трансплантированного сердца

Objective. The purpose of this study was to assess the state of left ventricular (LV) systolic dysfunction for an extended period after heart transplantation using the parameters of the functional geometry of the left ventricle. Material and Methods. The study included 31 patients after orthotopic heart transplantation with a follow-up period of up to nine years. We used linear discriminant analysis to build a classification model based on either the standard echocardiographic parameters of LV systolic function or parameters of LV functional geometry indexes aimed at the potential prediction of acute rejection and progression of chronic heart failure. Results. The linear discriminant analysis model based on parameters of LV functional geometry showed a high predictive value to diagnose acute rejection and development of heart failure in heart transplant patients. Conclusion. Linear discriminant analysis classification model based on the LV functional geometry data showed high accuracy in predicting allograft rejection and development of heart failure in heart transplant patients. © 2022 Industrial Laboratory. Materials Diagnostics. All rights reserved.The work was carried out within the framework of state assignments for the Ural State Medical University of Minzdrav of Russia (theme № AAAA-A18-118051590064) and Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences (theme No AAAAA18-118020590031-8). This work was supported by Decree of the Russian Government №211 of March 16, 2013 (agreement 02.A03.21.0006)

First search for gravitational waves from the youngest known neutron star

We present a search for periodic gravitational waves from the neutron star in the supernova remnant Cassiopeia A. The search coherently analyzes data in a 12 day interval taken from the fifth science run of the Laser Interferometer Gravitational-Wave Observatory. It searches gravitational-wave frequencies from 100 to 300 Hz and covers a wide range of first and second frequency derivatives appropriate for the age of the remnant and for different spin-down mechanisms. No gravitational-wave signal was detected. Within the range of search frequencies, we set 95% confidence upper limits of (0.7–1.2) × 10^(−24) on the intrinsic gravitational-wave strain, (0.4–4) × 10^(−4) on the equatorial ellipticity of the neutron star, and 0.005–0.14 on the amplitude of r-mode oscillations of the neutron star. These direct upper limits beat indirect limits derived from energy conservation and enter the range of theoretical predictions involving crystalline exotic matter or runaway r-modes. This paper is also the first gravitational-wave search to present upper limits on the r-mode amplitude