ДИАГНОСТИЧЕСКАЯ ЦЕННОСТЬ ОНКОМАРКЕРОВ TRF1 И MMP-7 В ОТНОШЕНИИ РАЗЛИЧНЫХ НОВООБРАЗОВАНИЙ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

 The authors analyzed the relative levels of telomeric repeat-binding protein factor 1 (TRF1) and matrix metalloproteinase-7 (MMR-7) mRNA expression by the cells obtained from prostate biopsy specimens of patients with benign prostate hyperplasia and cancer (PC) and healthy men without visible prostate diseases and calculated a TRF1/MMR-7 expression ratio for the above conditions. There was a statistically significant difference in the levels of TRF1 and MMP-7 expression and TRF1/MMP-7 ratio in the study groups, which may be suggestive of the high diagnostic value of these markers in determining the early-stage of PC and which enables clinicians to make a more accurate diagnosis in patients with various urologic diseases.Проанализированы относительные уровни экспрессии мРНК теломерсвязывающего белкового фактора (TRF1) и матриксеталлопротеиназы-7 (MMP-7) клетками, полученными из биоптатов предстательной железы пациентов с доброкачественной гиперплазией и раком предстательной железы (РПЖ) и здоровых мужчин, не имевших видимых заболеваний предстательной железы, и рассчитан индекс отношения уровней экспрессии TRF1/MMP-7 для указанных выше патологий. Установлено статистически достоверное различие уровней экспрессии TRF1, MMP-7 и индекса TRF1/MMP-7 в исследуемых группах, что может свидетельствовать о высокой диагностической значимости данных маркеров в отношении определения ранних стадий РПЖ и позволит клиницистам проводить более точную диагностику пациентов с различными урологическими заболеваниями

The aim of the research is to evaluate intravenosus laser irradiation of blood and low intеnsive laser irradiation in treatment of patients with acute pielonephritis

Results showed that patients who received intravenosus laser irradiation of blood and low intensive laser irradiation in addition to tradicional treatment showed reduction of inflammatory process. It occurs due to influence on patogenetic steps of acute pyelonephritisd and confirmed by data ortained at laboratory, мicrobiological, instrumental rentaenological and VS-methods of examination

PROGNOSTIC SIGNIFICANCE OF KI-67, MMP-9 AND COL IV IMMUNOHISTOCHEMICAL MARKERS AT BLADDER TUMORS

The prognostic value of the expression Ki-67, ММР-9 and collagen IV were estimated in urotelial bladder tumors. The biopsy and surgery samples from 43 patients (27 males and 16 females ) aged 42 to 87 years (mean age 66 ± 1.5 years) who received combination treatment for urotelial tumors. It has been found that Ki-67, ММР-9 and collagen IV are important prognostic markers of urotelial invasive bladder carcinoma

Diagnostic and prognostic importance of Ki-67, MMP-9 and collagen iv immunohistochemical markers in bladder tumors

The prognostic value of the expression Ki-67, ММР-9 and collagen IV in urotelial bladder tumors were estimated. The biopsy and surgery samples from 43patients (27males and 16 females) aged from 42 till 87 years (average age 66 ± 1,5 years) who received combined therapy for urotelial tumors were analyzed. It has been found that Ki-67, ММР-9 and collagen IV are important prognostic markers of urotelial invasive bladder carcinoma (BC)

Prostate blood flow in patients with benign prostatic hyperplasia complicated by urine retention

Benign prostatic hyperplasia is the most frequent disease among middle and old aged men and connected with increasing of lifetime of men. The incidence of the disease is 42% to 87% in different aged groups. Purpose: to improve the diagnosis of benign prostatic hyperplasia without complications and with urine retention. 38 patients with benign prostatic hyperplasia underwent transrectal sonography with estimation of blood flow by Doppler. Blood flow speed measured in subcapsular and paraurethral arteries with estimation of diameter and blood speed in veins of the paraprostatic tissue. Transrectal sonography showed the changes in the prostatic blood-flow, especially in case of urine retention. Transrectal ultrsonography plays an important role in the evaluation of the prostatic blood-flow

The comparason of the facts of cytological and histological analyses in case of chronic prostatitis

It has bee done comparison of the facts of cytological and histological analyses in case of chronic prostatitis. It has been established that 64 patient had mainly an acssudativ form of the inflammatory reaction, 49 patients had productive and 39 patients had proliferate phase of an acute inflammatory. PSA indexes more than 4 ng/ml have indicated the necessity of biopsy. This research, including the quantitative value of polumorphnonucleas leucocytes, eosynophyliq leucocytes, basophilic leucocytes, plasmatic cells, mononuclear leucocytes, and macrophages and fibroblast, has brought to light an absolute accordance of the facts cytological analyze. Which had been obtained by the exploration of secrets of prostate and the facts of histological analyze of byoptate of prostate

The role of matrix metalloproteinases and vascular grouth facrors in differentional diagnostic of prostate’s diseases

The aim of this study was to determine of TRF1, MMP-7, FLT-1, KDR and VEGF mRNA expression levels obtained from prostate biopsies samples of patients with benign prostatic hyperplasia, prostate cancer and healthy men without prostate pathology. It was demonstrated that detection of TRF1, FLT-1, KDR and MMP-7 expression levels correlations and TRF1/MMP-7 index was criteria of different way for different prostate neoplasm diagnostics

Efficacy of longidaza in prevention of sclerous processes after surgery on urinary tracts

The success of the surgery performed on the urinary tract, much depends on preventing scar-sclerotic complications in the postoperative period. In this regard, an important issue is to find a path genetically based methods to prevent the development of urinary tract strictures. After performing surgical procedures on the urinary tract of a complex drug therapy by Longidaza 3000 IU in combination with magnetic-laser therapy can reduce the development of sclerotic complications in 3 times, which reduces the number of repeat surgery, and can be recommended for use in clinical practice

DIAGNOSTIC VALUE OF TRF1 AND MMP-7 AGAINST VARIOUS PROSTATE NEOPLASMS

<p> The authors analyzed the relative levels of telomeric repeat-binding protein factor 1 (TRF1) and matrix metalloproteinase-7 (MMR-7) mRNA expression by the cells obtained from prostate biopsy specimens of patients with benign prostate hyperplasia and cancer (PC) and healthy men without visible prostate diseases and calculated a TRF1/MMR-7 expression ratio for the above conditions. There was a statistically significant difference in the levels of TRF1 and MMP-7 expression and TRF1/MMP-7 ratio in the study groups, which may be suggestive of the high diagnostic value of these markers in determining the early-stage of PC and which enables clinicians to make a more accurate diagnosis in patients with various urologic diseases.</p