Electron beam poling of [001]c-poled PMN-39PT single crystal

The equipment of the Ural Center for Shared Use “Modern Nanotechnology” UrFU has been used. The research was made possible in part by Government of the Russian Federation (Act 211, Agreement 02.180 A03.21.0006) and RFBR (grant 17-52-80116-BRICS_a)

Self-organized growth of dendrite domains in lithium niobate and lithium tantalate single crystals

The equipment of the Ural Center for Shared Use “Modern nanotechnology” UrFU was used. The research was made possible by Russian Science Foundation (Project №14-12-00826)

Local polarization reversal in relaxor SBN single crystals by electron and ion beam irradiation

The equipment of the Ural Center for Shared Use “Modern Nanotechnology” UrFU was used. The research was made possible by the Russian Science Foundation (grant № 19-72-00008)

Formation of dendrite domain structures in single crystals of lithium niobate

The equipment of Ural Center for Shared Use “Modern Nanotechnology” Ural Federal University was used. The research was made possible by Russian Science Foundation (Project № 19-12-00210)

Study of domain formation induced by ion beam in lithium tantalate

Изучено формирование доменной структуры под действием сфокусированного ионного пучка в кристаллах танталата лития. Результаты использованы для создания регулярных доменных структур (РДС) с малыми периодами.The domain formation induced by focused ion beam irradiation has been studied in congruent lithium tantalate single crystals. The obtained results have been used for periodical poling with short periods.Работа выполнена с использованием оборудования УЦКП «Современные нанотехнологии» УрФУ при финансовой поддержке гранта Президента РФ для молодых ученых (МК-8441.2016.2) и Правительства РФ (акт 211, соглашение 02.A03.21.0006)

Evaluation of nonlinear dynamics of the cell structure damage as a promising method for personalized cancer diagnostics

Background: Modulation interference microscopy is one of the promising technologies for early personalized cancer diagnostics, while it gives the possibility to obtain real-time images of living functioning cells at a nanometer resolution, as well as to assess spatio-temporal changes of their intracellular structures.Aim: To identify the markers of malignant transformation of cells based on a multiple scale spatio-temporal of the data obtained by lase interferometry during in situ registration of changes in intracellular structures.Materials and methods: The study was performed with the breast adenocarcinoma MCF-7 cell line and human kidney epithelial cells HEK 293 provided by the N.N. Blokhin National Medical Research Centre of Oncology (Moscow, Russia). Changes in fluctuation of the living cell phase thickness were measured with a laser modulation interference microscope MIM-340 (PA UOMZ, Russia). The multifractal detrended fluctuation analysis (MF-DFA) was used to assess the results obtained.Results: By comparison of the scaling exponential spectra and corresponding spectra of the singular fluctuations in the minimal and maximal diameters of the phase pictures of HEK 293 cells and MCF-7 cells, it was shown that the cancer cell dynamics has definite monofractal properties: a linear dependency of the scaling exponents τ from the actual q parameter and “dotted” singularity spectrum (the spectral width does not exceed 0.1). The dynamics of healthy cell demonstrated multifractal properties, such as a non-linear dependency τ(q) and a bell shaped singularity spectrum (the spectral width over 0.1).Conclusion: We have proposed a new approach to assess the intracellular structural damage during oncogenesis. The signs of monofractality are objective criteria of malignization. The results obtained seems promising as early diagnostic markers of cancer transformation (damage) of cells and determination of tumor cell sensitivity / resistance to anti-tumor agents in an individual patient

INFLUENCE OF BETA-ENDORPHIN ON IL-1β, TNF-α AND IL-10 SECRETION BY PERITONEAL MURINE MACROPHAGES

It was presented beta-endorphin was reduced spontaneous IL-1. and IL-10 secretion by the peritoneal murine macrophages, but had no effect on the levels of TNF. in the cell cultures. The opsonized zymosan addition in the culture abrogated the effects of beta-endorphin.Работа поддержана грантом программы Президиума РАН «Молекулярная и клеточная биология»