114 research outputs found

    Influence of planting material, plant population and organic manures on galangal (Kaempferia galanga L.) grown as intercrop in coconut (Cocos nucifera L.) garden

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    Field experiments conducted at Kasaragod, India to study the influence of planting material, plant population and organic manures on galangal (Kaempferia golanga) grown as intcrcrop in coconut (Cocos nucifcra) garden revealed that when mother rhizome was used as planting material significantly higher rhizome yield was achieved compared to finger rhizome. Plant population did not influence yleld. Farnl yard manure and major nutrient combinations recorded significantly higher yield compared to farm yard manure, vermicompost, composted coir pith and major nutrients applied alone. &nbsp

    Nutrient content and uptake by galangal (Kaempferia galanga L.) as influenced by agronomic practices as intercrop in coconut (Cocos nucifera L.) garden

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    Field experiments conducted at Kasaragod, India, to study the influence of agronomic practices on galangal (Kaempferia galanga) grown as intercrop in coconut (Cocos nucifera) garden revealed that nutrient content did not differ significantly due to different types of planting material or plant population levels. Farm yard manure alone, vermicompost alone and farm yard manure and major nutrient combinations had higher nutrient contents. Nutrient uptake with mother rhizome treatment was significantly higher compared to finger rhizome. Population level of 5,00,000 plants per ha removed more nutrients. Farm yard manure alone, vermicompost application alone and farm yard manure and major nutrient combinations removed higher nutrients. Fresh rhizome yield was significanlty higher with mother rhizome and 5,00,000 population leveL Farm yard manure in combination with major nutrients recorded significantly higher fresh rhizome yield. &nbsp

    A proteomic approach for the rapid, multi-informative and reliable identification of blood

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    Blood evidence is frequently encountered at the scene of violent crimes and can provide valuable intelligence in the forensic investigation of serious offences. Because many of the current enhancement methods used by crime scene investigators are presumptive, the visualisation of blood is not always reliable nor does it bear additional information. In the work presented here, two methods employing a shotgun bottom up proteomic approach for the detection of blood are reported; the developed protocols employ both an in solution digestion method and a recently proposed procedure involving immobilization of trypsin on hydrophobin Vmh2 coated MALDI sample plate. The methods are complementary as whilst one yields more identifiable proteins (as biomolecular signatures), the other is extremely rapid (5 minutes). Additionally, data demonstrate the opportunity to discriminate blood provenance even when two different blood sources are present in a mixture. This approach is also suitable for old bloodstains which had been previously chemically enhanced, as experiments conducted on a 9-year-old bloodstain deposited on a ceramic tile demonstrate

    A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway

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    Receptor activator of nuclear factor-kappa B ligand (RANKL) is a member of tumor necrosis factor (TNF) superfamily that plays a key role in the regulation of differentiation, activation and survival of osteoclasts and also in tumor cell migration and bone metastasis. Osteoclast activation induced by RANKL regulates hematopoietic stem cell mobilization as part of homeostasis and host defense mechanisms thereby linking regulation of hematopoiesis with bone remodeling. Binding of RANKL to its receptor, Receptor activator of nuclear factor-kappa B (RANK) activates molecules such as NF-kappa B, mitogen activated protein kinase (MAPK), nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K). Although the molecular and cellular roles of these molecules have been reported previously, a systematic cataloging of the molecular events induced by RANKL/RANK interaction has not been attempted. Here, we present a comprehensive reaction map of the RANKL/RANK-signaling pathway based on an extensive manual curation of the published literature. We hope that the curated RANKL/RANK-signaling pathway model would enable new biomedical discoveries, which can provide novel insights into disease processes and development of novel therapeutic interventions

    Yoga-Based Cardiac Rehabilitation After Acute Myocardial Infarction: A Randomized Trial

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    Background: Given the shortage of cardiac rehabilitation (CR) programs in India and poor uptake worldwide, there is an urgent need to find alternative models of CR that are inexpensive and may offer choice to subgroups with poor uptake (e.g., women and elderly). Objectives: This study sought to evaluate the effects of yoga-based CR (Yoga-CaRe) on major cardiovascular events and self-rated health in a multicenter randomized controlled trial. Methods: The trial was conducted in 24 medical centers across India. This study recruited 3,959 patients with acute myocardial infarction with a median and minimum follow-up of 22 and 6 months. Patients were individually randomized to receive either a Yoga-CaRe program (n = 1,970) or enhanced standard care involving educational advice (n = 1,989). The co-primary outcomes were: 1) first occurrence of major adverse cardiovascular events (MACE) (composite of all-cause mortality, myocardial infarction, stroke, or emergency cardiovascular hospitalization); and 2) self-rated health on the European Quality of Life–5 Dimensions–5 Level visual analogue scale at 12 weeks. Results: MACE occurred in 131 (6.7%) patients in the Yoga-CaRe group and 146 (7.4%) patients in the enhanced standard care group (hazard ratio with Yoga-CaRe: 0.90; 95% confidence interval [CI]: 0.71 to 1.15; p = 0.41). Self-rated health was 77 in Yoga-CaRe and 75.7 in the enhanced standard care group (baseline-adjusted mean difference in favor of Yoga-CaRe: 1.5; 95% CI: 0.5 to 2.5; p = 0.002). The Yoga-CaRe group had greater return to pre-infarct activities, but there was no difference in tobacco cessation or medication adherence between the treatment groups (secondary outcomes). Conclusions: Yoga-CaRe improved self-rated health and return to pre-infarct activities after acute myocardial infarction, but the trial lacked statistical power to show a difference in MACE. Yoga-CaRe may be an option when conventional CR is unavailable or unacceptable to individuals. (A study on effectiveness of YOGA based cardiac rehabilitation programme in India and United Kingdom; CTRI/2012/02/002408)

    Proteomics in India: the clinical aspect

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