Clinical evaluation of the implementation of the first pilot Russian integrated program for an integrated approach to the management of diabetes mellitus “NORMA”

BACKGROUND: Despite progress in the treatment of patients with diabetes mellitus (DM), the problem of achieving target values of glycemic control remains relevant. In this regard, the search for new integrated solutions that could strengthen disease control and improve clinical outcomes becomes relevant.AIM: To assess the impact of the developed integrated approach to disease management on the clinical and metabolic outcomes of patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) participating in the “NORMA” pilot program for 3 and 6 months.MATERIALS AND METHODS: “NORMA” is the first Russian program designed to implement an integrated approach to DM management combines structured online education, blood glucose monitoring, supervision by endocrinologist, and administrative support. Interium retrospective analysis analysis of pre-existing data generated in the Program was performed from October 2020 to November 2021. Adults (≥18 years) with uncontrolled T1DM or T2DM on insulin (HbA1c>7,0%) with duration of DM ≥6 months were included. The following characteristics were considered: social-demographic parameters, duration of DM, complications, HbA1c, hypoglycemia events, daily insulin dose, patients’ perception of DM checklist (scaled 1-10), level of DM knowledge (questionnaire of 20 points).RESULTS: Data from 185 persons were analyzed: 132 with T1DM and 53 with T2DM, 67% women, the mean age was 41.3±14.4 years; the median DM duration was 12.0 [6.0; 19.0] years, 30 persons (16.3%) were free of any DM complications. Mean HbA1c decreased from 8.8±1.5% to 7.4±1.2% at month 3, and to 7.6±1.5% at month 6 (p<0.001). HbA1c <7.0% was achieved in 38.9% and 38.1% participants after 3 and 6 months, respectively. The total insulin dose has not changed within the program. The DM knowledge level after 3 months of Program increased significantly by 25.4±15.0% (p<0.001). The mean scores of patients’ perceptions of DM after 3 and 6 months increased by 2.1±10.2 % and 2.4±11.0 % (p<0.01), but the median scores (interquartile range) did not change: 0.00% (-3.00–6.00%) and 0.50% (-3.00–9.00%) respectively.CONCLUSION: In a real-life setting, the implementation of an integrated approach to the diabetes management was associated with the improvement of glycemic control without significant changes of total insulin dose

A MODERN APPROACH TO THE CONSTRUCTION OF THE INFORMATION-ANALYTICAL SYSTEM OF STATUS AND DEVELOPMENT OF SCIENTIFIC SPHERE IN INSTITUTIONS OF HIGHER EDUCATION

The article presents the results of analysis of functioning at university and federal levels information-analytical systems describing the scientifi c sphere. It is concluded that there is no automatic link between the information analytical systems of given levels, so an approach is suggested to architecting a single information-analytical system of state and development of scientifi c sphere in institutions of higher education

Synthesis of allomaltol containing terarylenes with imidazole <i>N</i>-oxides bridge fragment

Method for the synthesis of previously unknown imidazole N-oxides bearing allomaltol unit has been elaborated. The presented approach is based on multicomponent condensation of corresponding oximes containing aroyl and 3-hydroxypyran-4-one fragments with various aldehydes and amines. The advantages of considered method are easily available starting compounds, atom economy, simple experimental procedure including isolation of the final products without column chromatography. The synthetic utility of prepared N-oxides was demonstrated by its further conversion to corresponding 2-chloroimidazole and 2-phenylaminoimidazole derivatives.</p

Mikhail Antonovich Shemberg and his scientific heritage (celebrating 70th birthday, 14.03.1951 – 22.01.2001)

Article analyzes the scientific achievements and heritage of Mikhail Antonovich Shemberg, a well-known dendrologist, who made a great contribution to the study of Siberian forests. He carried out a critical taxonomic treatment of birch Betula L. genus, developed new methodological approaches based on population-taxonomic analysis. M. A. Shemberg was the first who studied the variability of different features of birch species growing on the territory of Siberia and the Far East, revealed the patterns of their variability in individuals, populations, different parts of the area. He carried out a diagnostic assessment of these characteristics for the purposes of taxonomy and revealing of the intraspecific structure. The approaches of Mikhail A. Shemberg are widely used by specialists in the study of various generic complexes of woody plants. The pedagogical and public activity of Mikhail A. Shemberg is characterized. A list of major scientific works and list of theses defended under his supervision are given