ГИСТОСПЕКТРОФОТОМЕТРИЧЕСКОЕ И ИММУНОГИСТОХИМИЧЕСКОЕ ИССЛЕДОВАНИЕ РЕНАЛЬНОЙ ИНТРАТУБУЛЯРНОЙ НЕОПЛАЗИИ В ПЕРИТУМОРОЗНОЙ ЗОНЕ РАКА ПОЧКИ

In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations.В работе изучены проявления ренальной интратубулярной неоплазии (РИН) в перитуморозной зоне (ПЗ) рака почки. Материалом для исследования послужил операционный материал от 42 больных. Средний возраст пациентов составил 57,4 ± 1,4 года. Мужчин было 25, женщин — 17. С помощью гистологического, гистоспектрофотометрического и иммуногистохимического методов была исследована морфофункциональная характеристика эпителия канальцев в ПЗ рака почки. Показано, что в ПЗ опухолей высокой степени злокачественности проявления РИН встречались значительно чаще, чем при опухолях низких степеней анаплазии. В опухолях высокой степени анаплазии в эпителии канальцев ПЗ отмечали увеличение ядер, плоидности и экспрессии AgNORs, Ki-67, p53 и bcl-2. Наличие проявлений РИН в канальцевом эпителии ПЗ при раке почки следует учитывать при органосохраняющих операциях

КЛИНИЧЕСКИЕ АСПЕКТЫ ОПУХОЛЕВОГО АНГИОГЕНЕЗА В ПЕРИТУМОРОЗНОЙ ЗОНЕ У БОЛЬНЫХ РАКОМ ПОЧКИ

The specific features of tumor angiogenesis were studied in cancer-adjacent kidney tissues. The activity of neoangionesis in the peritumor area (PA) was shown to depend on the biological properties of a tumor and to be highest in high-grade tumors. The density of the PA microcirculatory bed correlated with the most important prognostic parameters for renal cell carcinoma and therefore it might be used as an additional prognostic factor in kidney cancer.Изучены особенности опухолевого ангиогенеза в тканях, прилежащих к раку почки. Показано, что активность неоангиогенеза в перитуморозной зоне (ПЗ) зависела от биологических свойств опухоли и была наиболее высока в опухолях высокой степени злокачественности. Плотность микроциркуляторного русла в ПЗ коррелировала с важнейшими прогностическими параметрами карциномы почки и поэтому может быть использована в качестве дополнительного фактора прогноза при раке почки

THE ANALYSIS OF RESULTS OF SURGICAL TREATMENT OF URINARY INCONTINENCE IN WOMEN: MORPHOLOGICAL ASPECTS

Anatomic changes ofparaurethral tissue in women with relapse of urinary incontinence due to stress may testify deficiency or dysplasiaof connective tissue. These may serve as reason of low efficacy of methods with use of own tissues for prolapse correction and urinary incontinence management. These determine the necessity of synthetic materials use

HISTOSPECTROPHOTOMETRICAL AND IMMUNOHISTOCHEMISTRICAL RESEARCH OF RENAL INTRATUBULAR NEOPLASIA IN PERITUMOUROUS ZONE OF A RENAL CARCINOMA

In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations

HISTOSPECTROPHOTOMETRICAL AND IMMUNOHISTOCHEMISTRICAL RESEARCH OF RENAL INTRATUBULAR NEOPLASIA IN PERITUMOUROUS ZONE OF A RENAL CARCINOMA

In this work displays renal intratubular neoplasia (RIN) in peritumourous zone of a renal carcinoma have been studied. The object of our work, are the operative materials of 42 patients. Middle age of patients has made 57,4 ± 1,4 year. Men was 25, women — 17. Characteristic of tubular epithelium in PZ a renal carcinoma have been studied morphofunctional by means of histological, histospectrophotometrical and immunohistochemistrical methods. It is shown, that in PZ tumors of a high degree displays, of RIN much more often, than in tumors of low degree anaplasia. In tumors of a high degree anaplasia in tubular epithelium PZ registered increasing of nucleus, ploidy and expression of AgNORs, Ki-67, p53 and bcl-2. The presence of displays RIN in tubular epithelium PZ at a renal carcinoma should be considered at surgery operations

TUMOR ANGIOGENESIS IN THE PERITUMOR AREA IN KIDNEY CANCER PATIENTS: CLINICAL ASPECTS

The specific features of tumor angiogenesis were studied in cancer-adjacent kidney tissues. The activity of neoangionesis in the peritumor area (PA) was shown to depend on the biological properties of a tumor and to be highest in high-grade tumors. The density of the PA microcirculatory bed correlated with the most important prognostic parameters for renal cell carcinoma and therefore it might be used as an additional prognostic factor in kidney cancer