111 research outputs found

    Rare Form of Breast Cancer and Lung Foci: Do We Always Have to Wait for Metastases?

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    Will the detected lung foci in patients with a burdened oncological history (breast cancer) always be metastatic? In response to the question posed, we present a clinical case of pulmonary sarcoidosis mimicking the metastatic lesion of metaplastic breast cancer. And we remind of the need for a differential diagnosis, despite the oncological history of a patient and radiation diagnostics data

    Π˜Π½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ особСнности стрСссорного рСагирования Π²ΠΎ врСмя психофизиологичСского исслСдования с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠ»ΠΈΠ³Ρ€Π°Ρ„Π°

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    The paper considers the inuence of subjects’ individual-typological dierences onphysiological characteristics of responding during a polygraph test. The authors evaluated: 1) the properties of the nervous system (strength, balance, and mobility) using the method of the complex visual-motor reaction; 2) character individual differences using the test of character accentuations (K. Leonhard – G.Shmishek);3)parameters of vegetative reactions of the subjects (the skin’s electrical activity, upper and lower breathing, cardiovascular activity, and tremor) using a β€œPOLARG-M” professional computer polygraph with β€œFemida” software. In the study with the use of a polygraph the authors applied the following methods: stimulus-adapting test (SAT),test of general control questions (TGCQ), and test on knowledge of the perpetrator (TKP). The study involved 30 respondents at the age from 18 to 24. The study showed that the respondents with the highest scores of the strength ofthe nervous system were able to successfully pass the polygraph test. The β€œanxiety–emotivity” characterological complex inuenced the amplitude of the positive and negative half waves in the channel of the skin’s electrical activity. The study demonstrated the conceptual possibility of the dierentiation of the subjects’ responding caused byanxiety or the signicance of a stimulus; this may help in avoiding false accusations. According to the authors, dierent ways of responding to stress can form individualforms of physiological reactions. Thus, the concept of individual symptom complex asaunique set of parameters of physiological reactions to subjectively signicant stimuli isthe most important.Π Π°Π±ΠΎΡ‚Π° посвящСна ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΡŽ влияния ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎ-типологичСских Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ испытуСмых Π½Π° физиологичСскиС ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ рСагирования Π²ΠΎ врСмя ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Ρ‹ тСстирования Π½Π° ΠΏΠΎΠ»ΠΈΠ³Ρ€Π°Ρ„Π΅. Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ Π±Ρ‹Π»Π° ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡ†Π΅Π½ΠΊΠ°: свойств Π½Π΅Ρ€Π²Π½ΠΎΠΉ систСмы (силы, баланса ΠΈ подвиТности) с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ Π‘Π—ΠœΠ -3 – слоТной Π·Ρ€ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ-ΠΌΠΎΡ‚ΠΎΡ€Π½ΠΎΠΉ Ρ€Π΅Π°ΠΊΡ†ΠΈΠΈ; характСрологичСских ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ тСста Π°ΠΊΡ†Π΅Π½Ρ‚ΡƒΠ°Ρ†ΠΈΠΉ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π° К. Π›Π΅ΠΎΠ½Π³Π°Ρ€Π΄Π° ΠΈ Π“. Π¨ΠΌΠΈΡˆΠ΅ΠΊΠ°; ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Π²Π΅Π³Π΅Ρ‚Π°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… Ρ€Π΅Π°ΠΊΡ†ΠΈΠΉ испытуСмых (элСктричСской активности ΠΊΠΎΠΆΠΈ, Π²Π΅Ρ€Ρ…Π½Π΅Π³ΠΎ ΠΈ Π½ΠΈΠΆΠ½Π΅Π³ΠΎ дыхания, сСрдСчно-сосудистой активности, Π° Ρ‚Π°ΠΊΠΆΠ΅ Ρ‚Ρ€Π΅ΠΌΠΎΡ€Π°) с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠ³Ρ€Π°Ρ„Π° Β«ΠŸΠžΠ›ΠΠ Π“-М» со ΡΠΏΠ΅Ρ†ΠΈΠ°Π»ΡŒΠ½Ρ‹ΠΌ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ½Ρ‹ΠΌ обСспСчСниСм Β«Π€Π΅ΠΌΠΈΠ΄Π°Β». Π’ исслСдовании с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠ»ΠΈΠ³Ρ€Π°Ρ„Π° ΠΏΡ€ΠΈΠΌΠ΅Π½ΡΠ»ΠΈΡΡŒ ΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΠ΅ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ: стимуляционно-Π°Π΄Π°ΠΏΡ‚ΠΈΡ€ΡƒΡŽΡ‰ΠΈΠΉ тСст (БАВ), тСст ΠΎΠ±Ρ‰ΠΈΡ… ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½Ρ‹Ρ… вопросов (Π’ΠžΠšΠ’) ΠΈ поисковый тСст Π½Π° знания Π²ΠΈΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ (П-Π’Π—Π’). Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ приняли участиС 30 Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊ Π² возрастС ΠΎΡ‚ 18 Π΄ΠΎ 24 Π»Π΅Ρ‚. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ исслСдования ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ испытуСмыС с ярко Π²Ρ‹Ρ€Π°ΠΆΠ΅Π½Π½Ρ‹ΠΌ свойством силы Π½Π΅Ρ€Π²Π½ΠΎΠΉ систСмы способны Π±ΠΎΠ»Π΅Π΅ ΡƒΡΠΏΠ΅ΡˆΠ½ΠΎ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΡΡ‚ΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΎΡ†Π΅Π΄ΡƒΡ€Π΅ тСстирования Π½Π° ΠΏΠΎΠ»ΠΈΠ³Ρ€Π°Ρ„Π΅. ВыявлСно влияниС характСрологичСского комплСкса Β«Ρ‚Ρ€Π΅Π²ΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ β€“ ΡΠΌΠΎΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΒ» Π½Π° Π°ΠΌΠΏΠ»ΠΈΡ‚ΡƒΠ΄Ρƒ ΠΏΠΎΠ·ΠΈΡ‚ΠΈΠ²Π½ΠΎΠΉ ΠΈ Π½Π΅Π³Π°Ρ‚ΠΈΠ²Π½ΠΎΠΉ ΠΏΠΎΠ»ΡƒΠ²ΠΎΠ»Π½ Π² ΠΊΠ°Π½Π°Π»Π΅ элСктричСской активности ΠΊΠΎΠΆΠΈ. Показана ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠΈΠ°Π»ΡŒΠ½Π°Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ диффСрСнцирования Ρ€Π΅Π°ΠΊΡ†ΠΈΠΉ испытуСмых, Π²Ρ‹Π·Π²Π°Π½Π½Ρ‹Ρ… Ρ‚Ρ€Π΅Π²ΠΎΠΆΠ½ΠΎΡΡ‚ΡŒΡŽ Π»ΠΈΠ±ΠΎ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒΡŽ стимула, Ρ‡Ρ‚ΠΎ позволяСт ΠΈΠ·Π±Π΅ΠΆΠ°Ρ‚ΡŒ ошибки Π»ΠΎΠΆΠ½ΠΎΠ³ΠΎ обвинСния. Показано, Ρ‡Ρ‚ΠΎ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Π΅ способы рСагирования Π½Π° стрСсс ΠΌΠΎΠ³ΡƒΡ‚ Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ Ρ„ΠΎΡ€ΠΌΡ‹ физиологичСских Ρ€Π΅Π°ΠΊΡ†ΠΈΠΉ. Π’ этих условиях ΠΊΠ»ΡŽΡ‡Π΅Π²ΠΎΠ΅ Π·Π½Π°Ρ‡Π΅Π½ΠΈΠ΅ ΠΏΡ€ΠΈΠΎΠ±Ρ€Π΅Ρ‚Π°Π΅Ρ‚ понятиС ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ симптомокомплСкса ΠΊΠ°ΠΊ ΡƒΠ½ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ Π½Π°Π±ΠΎΡ€Π° ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² физиологичСских Ρ€Π΅Π°ΠΊΡ†ΠΈΠΉ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡŽΡ‰ΠΈΡ… ΠΏΡ€ΠΈ ΠΏΡ€Π΅Π΄ΡŠΡΠ²Π»Π΅Π½ΠΈΠΈ исслСдуСмому Π»ΠΈΡ†Ρƒ ΡΡƒΠ±ΡŠΠ΅ΠΊΡ‚ΠΈΠ²Π½ΠΎ Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Ρ… стимулов

    Assessment of Stability of Chemical Cholera Vaccine in a New Primary Packaging

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    The bivalent chemical cholera vaccine is the only drug for the prevention of cholera registered in the Russian Federation. The vaccine has been produced in glass bottles containing 210 tablets. At the same time, modern trends dictate the need to produce the drug in varying dispensing and more practical packaging for the convenience of the consumer.The aim of the work was to study the stability of the properties of the immunobiological medicinal product β€œBivalent chemical cholera vaccine” with modified filling and in new primary packaging.Materials and methods. When studying the quality of bivalent chemical cholera vaccine batches, physicochemical parameters, formaldehyde content, specific activity and safety, abnormal toxicity, immunogenicity, and microbiological purity were assessed. Stability in terms of β€œspecific activity” was evaluated using dot immunoassay.Results and discussion. As a result of this work, the use of several dispensing options and new primary packaging of cholera vaccine has been experimentally substantiated. The stability of the finished vaccine preparation has been established in the β€œaccelerated aging” test and during long-term storage. The possibility of using dot immunoassay with a conjugate based on staphylococcal protein A, labeled with colloidal gold, to monitor the stability of cholera vaccine has been experimentally demonstrated

    On foliar fungal pathogens at species of the genus

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    The article determines the species composition of causative agents of plant leaf diseases of the genus Alnus Mill. for the Siberian region, that grow in the arboretum collections and urbanized environment. The author has identified four phytopathogens, their spread and harmfulness are specified; established the confinement of foliar fungal pathogens to the host plant species, its ontogeny phase, and abiotic environmental factors. It had been found a hyperparasite Ramularia uredinis (W. Voss) Sacc. on a causative agent of alder rust (Melampsoridium alni (Thum.) Dietel), for which this phytopathogen is a new host

    Complex Monitoring of Biochemical and Radionuclide Parameters in Patients with Metastatic Renal Cell Carcinoma during Immunotherapy

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    Study Objective. To study the effectiveness of complex monitoring of the kidney function, based on biochemical and radionuclide methods in patients with metastatic renal cell carcinoma (mRCC). Materials and Methods. 41 mRCC patients after nephrectomy received nivolumab (n = 23) and interferon-Ξ± (n = 18) from 2015 to 2017. At baseline and 2 months after, all patients underwent blood chemistry, urinalysis, Rehberg test, and ELISA to determine serum levels of IL-17A, TGF-Ξ², and erythropoietin. The monitoring of the renal function and urodynamics by complex renal scintigraphy (CRS) was used for all patients using a dual-detector gamma camera and simultaneous data recording in 2 projections. The interpretation of CRS data used the original SENS CRS technology. Study Results. Statistically significant correlations were established between IL-17A, TGF-Ξ², and D (excretion rate of 99mTc-technephore from the parenchyma) and Rnfsc (a stable sign of nephrosclerosis), respectively. A significant correlation was established between the parameters of the complex functional monitoring with the prognosis for the risk of renal failure (RF) and efficacy of immunotherapy in mRCC. Conclusions. All mRCC patients after nephrectomy were recommended to undergo biochemical monitoring with inclusion of TGF-Ξ² and IL-17A, as well as radionuclide monitoring (CRS) to determine the RF risk at an early stage
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