Об организации работ по стандартизации на воздушном транспорте с учетом национальных приоритетов

The article analyzes the organization of works on standardization of air transport of the Russian Federation in the framework of the activities of the Technical Committee on standardization "Air transport", according to national priorities.В статье приведен анализ организации работ по стандартизации на воздушном транспорте Российской Федерации в рамках деятельности Технического комитета по стандартизации "Воздушный транспорт" с учетом национальных приоритетов

Clinical effectiveness of long-term trimetazidine MB therapy in patients with cardio-respiratory disease (the results of an open, prospective multi-centre study)

Aim. To study the prevalence and clinical features of cardio-respiratory disease (CRD): coronary heart disease (CHD) + chronic obstructive pulmonary disease (COPD). To assess the long-term effectiveness of a myocardial cytoprotector, trimetazidine MB, as a part of complex therapy.Material and methods. The retrospective analysis of 2446 medical histories assessed CRD prevalence and clinical features. The subjects were randomised into two groups: Group I (135 patients with CHD and severe COPD) and Group II (96 individuals with CHD and moderate COPD). Group I was administered trimetazidine MB (70 mg/d) for one year. Control assessments took place every three months.Results. CRD was more prevalent in elderly CHD patients (56,7%). The combination of CHD and COPD was characterized by higher risk of Q-wave myocardial infarction (MI), unstable angina, complex arrhythmias, and early CHD progression, and increased time of silent myocardial ischemia. After one year of trimetazidine MB treatment, Group I demonstrated a significant decrease in angina episode incidence and silent myocardial ischemia time (p<0,05); in 64,4% of the patients, regression of cardiac symptoms and extrasystolia incidence were also observed.Conclusion. Long-term trimetazidine MB therapy, as a part of complex treatment, normalised cardiovascular parameters, reduced complication risk, and improved prognosis in CRD patients, without any substantial adverse effects

ON ORGANIZATION OF WORKS ON STANDARDIZATION OF AIR TRANSPORT WITH THE ACCOUNT NATIONAL PRIORITIES

The article analyzes the organization of works on standardization of air transport of the Russian Federation in the framework of the activities of the Technical Committee on standardization "Air transport", according to national priorities

X-ray diffraction studies of 6-methyl-5-acetyl-4-α -furyl-2-keto-1,2,3,6-tetrahydropyrimidine and 6-methyl-5-acetyl-4-γ -bromophenyl-2-thio- 1,2,3,6-tetrahydropyrimidine

6-Methyl-5-acetyl-4-α-furyl-2-keto-1,2,3,6-tetrahydropyrimidine (I) and 6-methyl-5-acetyl-4-γ-bromophenyl-2-thio-1,2,3,6-tetrahydropyrimidine (II) are prepared by the modified Biginelli reaction, and their crystal and molecular structures are studied. It is shown that, in crystals I and II, the pyrimidine ring has an amide tautomeric form and adopts a sofa conformation. The IR absorption spectra are analyzed, and the stability of the tautomers of the pyrimidine fragments is evaluated using quantum-chemical calculations. © 2003 MAIK "Nauka/Interperiodica"