830 research outputs found
Z radiation off stops at a linear collider
We calculate e+e- --> stop/stop/Z at a linear collider. For large splitting
between the two stops the cross-section is sensitive to the value of m(stop2)
when this particle is too heavy to be directly produced. The results are
compared to e+e- --> stop/stop/h.Comment: 19 pages, 8 figure
Implications of the HERA Events for the R-Parity Breaking SUSY Signals at Tevatron
The favoured R-parity violating SUSY scenarios for the anomalous HERA events
correspond to top and charm squark production via the and
couplings. In both cases the corresponding electronic
branching fractions of the squarks are expected to be . Consequently the
canonical leptoquark signature is incapable of probing these scenarios at the
Tevatron collider over most of the MSSM parameter space. We suggest alternative
signatures for probing them at Tevatron, which seem to be viable over the
entire range of MSSM parameters.Comment: 20 pages Latex file with 4 ps files containing 4 figure
Platelet rich plasma from different preparations: effect on chondrocytes and synoviocytes of osteoarthritis patients
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Soluble major histocompatibility complex class I-related chain B molecules are increased and correlate with clinical outcomes during rhinovirus infection in healthy subjects
BACKGROUND: Surface major histocompatibility complex class I-related chain (MIC) A and B molecules are increased by IL-15 and have a role in the activation of natural killer group 2 member D-positive natural killer and CD8 T cells. MICA and MICB also exist in soluble forms (sMICA and sMICB). Rhinoviruses (RVs) are the major cause of asthma exacerbations, and IL-15 levels are decreased in the airways of subjects with asthma. The role of MIC molecules in immune responses in the lung has not been studied. Here, we determine the relationship between MICA and MICB and RV infection in vitro in respiratory epithelial cells and in vivo in healthy subjects and subjects with asthma. METHODS: Surface MICA and MICB, as well as sMICA and sMICB, in respiratory epithelial cells were measured in vitro in response to RV infection and exposure to IL-15. Levels of sMICA and sMICB in serum, sputum, and BAL were measured and correlated with blood and bronchoalveolar immune cells in healthy subjects and subjects with asthma before and during RV infection. RESULTS: RV increased MICA and MICB in vitro in epithelial cells. Exogenous IL-15 upregulated sMICB levels in RV-infected epithelial cells. Levels of sMICB molecules in serum were increased in healthy subjects compared with subjects with stable asthma. Following RV infection, airway levels of sMIC are upregulated, and there are positive correlations between sputum MICB levels and the percentage of bronchoalveolar natural killer cells in healthy subjects but not subjects with asthma. CONCLUSIONS: RV infection induces MIC molecules in respiratory epithelial cells in vitro and in vivo. Induction of MICB molecules is impaired in subjects with asthma, suggesting these molecules may have a role in the antiviral immune response to RV infections
Much Ado About Leptoquarks: A Comprehensive Analysis
We examine the phenomenological implications of a 200 GeV leptoquark in light
of the recent excess of events at HERA. Given the relative predictions of
events rates in e^+p versus e^-p, we demonstrate that classes of leptoquarks
may be excluded, including those contained in E_6 GUT models. It is shown that
future studies with polarized beams at HERA could reveal the chirality of the
leptoquark fermionic coupling and that given sufficient luminosity in each
e^\pm_{L,R} channel the leptoquark quantum numbers could be determined. The
implications of 200-220 GeV leptoquarks at the Tevatron are examined. While
present Tevatron data most likely excludes vector leptoquarks and leptogluons
in this mass region, it does allow for scalar leptoquarks. We find that while
leptoquarks have little influence on Drell-Yan production, further studies at
the Main Injector are possible in the single production channel. We investigate
precision electroweak measurements as well as the process e^+e^-\to q\bar q at
LEP II and find they provide no further restrictions on these leptoquark
models. We then ascertain that cross section and polarization asymmetry
measurements at the NLC provide the only direct mechanism to determine the
leptoquark's electroweak quantum numbers. The single production of leptoquarks
in \gamma e collisions by both the backscattered laser and Weisacker-Williams
techniques at the NLC is also discussed. Finally, we demonstrate that we can
obtain successful coupling constant unification in models with leptoquarks,
both with or without supersymmetry. The supersymmetric case requires the GUT
group to be larger than SU(5) such as flipped SU(5)\times U(1)_X.Comment: Corrected single production cross section at Tevatron, updated atomic
parity violation constraints, 55 page
CXC chemokines and antimicrobial peptides in rhinovirus-induced experimental asthma exacerbations
RATIONALE: Rhinoviruses (RVs) are the major triggers of asthma exacerbations. We have shown previously that lower respiratory tract symptoms, airflow obstruction, and neutrophilic airway inflammation were increased in experimental RV-induced asthma exacerbations. OBJECTIVES: We hypothesized that neutrophil-related CXC chemokines and antimicrobial peptides are increased and related to clinical, virologic, and pathologic outcomes in RV-induced exacerbations of asthma. METHODS: Protein levels of antimicrobial peptides (SLPI, HNP 1–3, elafin, and LL-37) and neutrophil chemokines (CXCL1/GRO-α, CXCL2/GRO-β, CXCL5/ENA-78, CXCL6/GCP-2, CXCL7/NAP-2, and CXCL8/IL-8) were determined in bronchoalveolar lavage (BAL) fluid of 10 asthmatics and 15 normal controls taken before, at day four during and 6 weeks post-experimental infection. RESULTS: BAL HNP 1–3 and Elafin were higher, CXCL7/NAP-2 was lower in asthmatics compared with controls at day 4 (P = 0.035, P = 0.048, and P = 0.025, respectively). BAL HNP 1–3 and CXCL8/IL-8 were increased during infection (P = 0.003 and P = 0.011, respectively). There was a trend to increased BAL neutrophils at day 4 compared with baseline (P = 0.076). BAL HNP 1–3 was positively correlated with BAL neutrophil numbers at day 4. There were no correlations between clinical parameters and HNP1–3 or IL-8 levels. CONCLUSIONS: We propose that RV infection in asthma leads to increased release of CXCL8/IL-8, attracting neutrophils into the airways where they release HNP 1–3, which further enhances airway neutrophilia. Strategies to inhibit CXCL8/IL-8 may be useful in treatment of virus-induced asthma exacerbations
Don't Stop Thinking About Leptoquarks: Constructing New Models
We discuss the general framework for the construction of new models
containing a single, fermion number zero scalar leptoquark of mass GeV which can both satisfy the D0/CDF search constraints as well as
low energy data, and can lead to both neutral and charged current-like final
states at HERA. The class of models of this kind necessarily contain new
vector-like fermions with masses at the TeV scale which mix with those of the
Standard Model after symmetry breaking. In this paper we classify all models of
this type and examine their phenomenological implications as well as their
potential embedding into SUSY and non-SUSY GUT scenarios. The general coupling
parameter space allowed by low energy as well as collider data for these models
is described and requires no fine-tuning of the parameters.Comment: Modified text, added table, and updated reference
Global Study of Electron-Quark Contact Interactions
We perform a global fit of data relevant to contact interactions,
including deep inelastic scattering at high from ZEUS and H1, atomic
physics parity violation in Cesium from JILA, polarized on nuclei
scattering experiments at SLAC, Mainz and Bates, Drell-Yan production at the
Tevatron, the total hadronic cross section at LEP, and
neutrino-nucleon scattering from CCFR. With only the new HERA data, the
presence of contact interactions improves the fit compared to the Standard
Model. When other data sets are included, the size of the contact contributions
is reduced and the overall fit represents no real improvement over the Standard
Model.Comment: 26 pages (now single-spaced), Revtex, 2 eps figures, uses epsf.sty.
Some clarifications, minor corrections, 2 new references, also 3 new tables
which present 95% CL bounds on the contact interaction scales Lambd
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