Динаміка формування мікробіоценозу кишечника у дітей першого року життя

The paper is devoted to the colonization dynamics of babies’ intestines by the permanent gut organisms during the first 10 days of life. The microbial intestine complex of these babies’ mothers of different age groups has been studied. Infants under one year have quantitative fluctuations of the gut organisms. Показано динаміку заселення кишечника немовлят у перші десять діб життя видами мікроорганізмів, що складатимуть постійну мікрофлору. Досліджено мікробний пейзаж кишечника породіль різних вікових груп. Виявлено коливання кількісних показників кишечної мікрофлори у дітей першого року життя. Показано динаміку заселення кишечника немовлят у перші десять діб життя видами мікроорганізмів, що складатимуть постійну мікрофлору. Досліджено мікробний пейзаж кишечника породіль різних вікових груп. Виявлено коливання кількісних показників кишечної мікрофлори у дітей першого року життя.

Unsteady undular bores in fully nonlinear shallow-water theory

We consider unsteady undular bores for a pair of coupled equations of Boussinesq-type which contain the familiar fully nonlinear dissipationless shallow-water dynamics and the leading-order fully nonlinear dispersive terms. This system contains one horizontal space dimension and time and can be systematically derived from the full Euler equations for irrotational flows with a free surface using a standard long-wave asymptotic expansion. In this context the system was first derived by Su and Gardner. It coincides with the one-dimensional flat-bottom reduction of the Green-Naghdi system and, additionally, has recently found a number of fluid dynamics applications other than the present context of shallow-water gravity waves. We then use the Whitham modulation theory for a one-phase periodic travelling wave to obtain an asymptotic analytical description of an undular bore in the Su-Gardner system for a full range of "depth" ratios across the bore. The positions of the leading and trailing edges of the undular bore and the amplitude of the leading solitary wave of the bore are found as functions of this "depth ratio". The formation of a partial undular bore with a rapidly-varying finite-amplitude trailing wave front is predicted for ``depth ratios'' across the bore exceeding 1.43. The analytical results from the modulation theory are shown to be in excellent agreement with full numerical solutions for the development of an undular bore in the Su-Gardner system.Comment: Revised version accepted for publication in Phys. Fluids, 51 pages, 9 figure

Quarantine contagion dynamics in the city of Dnipropetrovsk and Mezhova district

Показано динамiку розповсюдження карантинних iнфекцiй у мiстi Днiпропетровськ та Межiвському районi. Дослiджено поширення повiтряно-крапельних і гострих кишкових захворювань за останні 10 років (з 1996 по 2006-й). По м. Дніпропетровськ зареєстровано спалахи захворювань на дифтерiю, менiнгiт, сальмонельоз, дизентерiю та ешерихiози, по Межівському району – на дифтерiю та сальмонельоз.Показано динамiку розповсюдження карантинних iнфекцiй у мiстi Днiпропетровськ та Межiвському районi. Дослiджено поширення повiтряно-крапельних і гострих кишкових захворювань за останні 10 років (з 1996 по 2006-й). По м. Дніпропетровськ зареєстровано спалахи захворювань на дифтерiю, менiнгiт, сальмонельоз, дизентерiю та ешерихiози, по Межівському району – на дифтерiю та сальмонельоз.The quarantine contagion dynamics in the city ofDnipropetrovskand Mezhova district is presented. The circulation of respiratory infections and acute intestinal diseases for last 10 years (1996–2006) was studied. The infective episodes of diphtheria, meningitis, salmonellosis, dysentery and escherichiosis in the Dnipropetrovsk city were registered. We observed the incidence rate of dyphtheria and salmonellosis in the Mezhova district.

Изучение процессов дыхания у клинических антибиотикорезистентных штаммов стафилококков

54 staphylococcus strains with different resistance levels to a number of antibiotics have been extracted from the reproductive canal of women who had a miscarriage. The respiration activity of the selected cultures has been studied. Endogenic respiration processes in staphylococcus cells intensified in consequence of the development of antimicrobial medication resistance.Із репродуктивного тракту жінок, котрі не виношували вагітність, виділено 54 штами стафілококів із різним рівнем стійкості до ряду антибіотиків. Проведено дослідження дихальної активності у виділених культур. Показана інтенсифікація процесів ендогенного дихання клітин стафілококів у результаті розвитку стійкості до антимікробних препаратів.Із репродуктивного тракту жінок, котрі не виношували вагітність, виділено 54 штами стафілококів із різним рівнем стійкості до ряду антибіотиків. Проведено дослідження дихальної активності у виділених культур. Показана інтенсифікація процесів ендогенного дихання клітин стафілококів у результаті розвитку стійкості до антимікробних препаратів

Tunability of solitary wave properties in one dimensional strongly nonlinear phononic crystals

One dimentional strongly nonlinear phononic crystals were assembled from chains of PTFE (polytetrafluoroethylene) and stainless steel spheres with gauges installed inside the beads. Trains of strongly nonlinear solitary waves were excited by an impact. A significant modification of the signal shape and an increase of solitary wave speed up to two times (at the same amplitude of dynamic contact force)were achieved through a noncontact magnetically induced precompression of the chains. Data for PTFE based chains are presented for the first time and data for stainless steel based chains were extended into a smaller range of amplitudes by more than one order of magnitude than previously reported. Experimental results were found to be in reasonable agreement with the long wave approximation and with numerical calculations based on Hertz interaction law for discrete chains.Comment: 36 pages, 7 figure

PERSONALIZED PHARMACOLOGICAL CORRECTION OF IMMUNE SYSTEMS, METABOLIC AND NEUROPSYCHIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA OF STAGE I AND II ON THE BACKGROUND OF HYPERTENSION DISEASE

The study aimed to develop a personalized pharmacological correction of immune, metabolic and neuropsychiatric disorders in chronic cerebral ischemia (CCI) stages I and II. The study included 104 patients, of which 76 were female and 28 were male, with CCI on the background of grade II hypertension, of which 52 patients were with stage I and 52 with stage II at the age of 50±5 years. Clinical and laboratory parameters were studied in 22 healthy donors of the same age who formed a control group. Patients with CCI were randomized according to gender, age, treatment method, concomitant pathology, and duration of the disease. Evaluation of clinical and laboratory data was carried out at the beginning of treatment and 2 weeks after its end. The sorption capacity of erythrocytes and the sorption capacity of the glycocalyx (SEG), the activity of lipid peroxidation processes, the state of the antioxidant system were determined in blood plasma and erythrocytes, the level of stable metabolites of nitric oxide (SMNO), neopterin, C-reactive protein, cytokines (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA), complement system components (C3, C4, C5, C5A), phagocytic and oxygen-dependent activity of polymorphonuclear blood leukocytes. It has been established that for patients with CCI I with high concentrations of IL-8, IL-10, SMNO and a low SEG index, the intake of Cereton and Actovegin or Ceraxon and Mexicor will be insufficient for effective correction of immunometabolic disorders, which requires additional administration of an immunomodulator. Patients with CCI II, who have a higher plasma level of TNFα, IL-10 and low SEG values, need to prescribe Ceraxon, Mexicor and Glutoxim or Ceraxon, Mexicor and Polyoxidonium in order to obtain the maximum clinical and laboratory positive effect

Assessment of Association of rs2200733 SNP on Chromosome 4q25 with the Risk of the Development of Atrial Fibrillation in the Russian Population

The aim of our case-control study was to investigate the possible genetic association of the rs2200733 SNP on chromosome 4q25 with AF in the Russian population as this association has not been examined before in this ethnicity. Methods and Results: A total of 76 unrelated individuals diagnosed with AF and 73 control subjects without any cardiovascular pathology were included in this study. The diagnosis of AF was based on ECG and/or Holter ECG data following standard diagnostic criteria. We found that the TT genotype of the rs2200733 SNP was associated with a higher risk of AF (OR=1.4, 95% CI: 1.1-12.4). The homozygote minor rare allele genotype TT of the rs2200733 SNP tended to elevate the risk of lone AF development (OR=2.5, 95% CI: 1.2-19.5). A risk of secondary AF development did not depend on rs2200733 SNP on chromosome 4q25 (OR=0.5, 95% CI: 0.2-1.3). Conclusion: Our results provide additional evidence for the association between the rs2200733 (4q25) SNP on chromosome 4q25 and AF, emphasizing the need for further studies examining the role of this polymorphism in AF

Magnetoelectric ordering of BiFeO3 from the perspective of crystal chemistry

In this paper we examine the role of crystal chemistry factors in creating conditions for formation of magnetoelectric ordering in BiFeO3. It is generally accepted that the main reason of the ferroelectric distortion in BiFeO3 is concerned with a stereochemical activity of the Bi lone pair. However, the lone pair is stereochemically active in the paraelectric orthorhombic beta-phase as well. We demonstrate that a crucial role in emerging of phase transitions of the metal-insulator, paraelectric-ferroelectric and magnetic disorder-order types belongs to the change of the degree of the lone pair stereochemical activity - its consecutive increase with the temperature decrease. Using the structural data, we calculated the sign and strength of magnetic couplings in BiFeO3 in the range from 945 C down to 25 C and found the couplings, which undergo the antiferromagnetic-ferromagnetic transition with the temperature decrease and give rise to the antiferromagnetic ordering and its delay in regard to temperature, as compared to the ferroelectric ordering. We discuss the reasons of emerging of the spatially modulated spin structure and its suppression by doping with La3+.Comment: 18 pages, 5 figures, 3 table