Hemopexin and Cancer

Hemopexin is the plasma protein with the highest affinity for heme. Seminal studies have highlighted its role in different kinds of heme-associated disorders, but its implication in cancer has been neglected for a long time. Considering the emerging importance of heme in tumors, the present review proposes an update of the works investigating hemopexin involvement in cancer, with the attempt to stimulate further future studies on this topic

Interference of diffraction and transition radiation and its application as a beam divergence diagnostic

We have observed the interference of optical diffraction radiation (ODR) and optical transition radiation (OTR) produced by the interaction of a relativistic electron beam with a micromesh foil and a mirror. The production of forward directed ODR from electrons passing through the holes and wires of the mesh and their separate interactions with backward OTR from the mirror are analyzed with the help of a simulation code. By careful choice of the micromesh properties, mesh-mirror spacing, observation wavelength and filter band pass, the interference of the ODR produced from the unperturbed electrons passing through the open spaces of the mesh and OTR from the mirror are observable above a broad incoherent background from interaction of the heavily scattered electrons passing through the mesh wires. These interferences (ODTRI) are sensitive to the beam divergence and can be used to directly diagnose this parameter. We compare experimental divergence values obtained using ODTRI, conventional OTRI, for the case when front foil scattering is negligible, and computed values obtained from transport code calculations and multiple screen beam size measurements. We obtain good agreement in all cases.Comment: 40 pages 18 Figures. accepted for publication in PRSTA

Interference of diffraction and transition radiation and its application as a beam divergence diagnostic

The article of record as published may be found at http://dx.doi.org/10.1103/PhysRevSTAB.9.052802We have observed the interference of optical diffraction radiation (ODR) and optical transition radiation (OTR) produced by the interaction of a relativistic electron beam with a micromesh foil and a mirror. The production of forward directed ODR from electrons passing through the holes and wires of the mesh and their separate interactions with backward OTR from the mirror are analyzed with the help of a simulation code. By careful choice of the micromesh properties, mesh-mirror spacing, observation wavelength, and filter band pass, the interference of the ODR produced from the unperturbed electrons passing through the open spaces of the mesh and OTR from the mirror are observable above a broad incoherent background from interaction of the heavily scattered electrons passing through the mesh wires. These interferences (ODTRI) are sensitive to the beam divergence and can be used to directly diagnose this parameter. We compare experimental divergence values obtained using ODTRI, conventional OTRI, for the case when front foil scattering is negligible, and computed values obtained from transport code calculations and multiple screen beam size measurements. We obtain good agreement in all cases.This work is supported by the Office of Naval Research and the DOD Joint Technology Offic

Camouflage during movement in the European cuttlefish (Sepia officinalis)

A moving object is considered conspicuous because of the movement itself. When moving from one background to another, even dynamic camouflage experts such as cephalopods should sacrifice their extraordinary camouflage. Therefore, minimizing detection at this stage is crucial and highly beneficial. In this study, we describe a background-matching mechanism during movement, which aids the cuttlefish to downplay its presence throughout movement. In situ behavioural experiments using video and image analysis, revealed a delayed, sigmoidal, colour-changing mechanism during movement of Sepia officinalis across uniform black and grey backgrounds. This is a first important step in understanding dynamic camouflage during movement, and this new behavioural mechanism may be incorporated and applied to any dynamic camouflaging animal or man-made system on the move.info:eu-repo/semantics/publishedVersio

Multi-component measurements of the Jefferson Lab energy recovery linac electron beam using optical transition and diffraction radiation

High brightness electron accelerators, such as energy recovery linacs (ERL), often have complex particle distributions that can create difficulties in beam transport as well as matching to devices such as wigglers used to generate radiation from the beam. Optical transition radiation (OTR), OTR interferometry (OTRI) and optical diffraction-transition radiation interferometry (ODTRI) have proven to be effective tools for diagnosing both the spatial and angular distributions of charged particle beams. OTRI and ODTRI have been used to measure rms divergences and optical transverse phase space mapping has been demonstrated using OTRI. In this work we present the results of diagnostic experiments using OTR and ODR conducted at the Jefferson Laboratory 115 MeV ERL which show the presence of two separate components within the spatial and angular distributions of the beam. By assuming a correlation between the spatial and angular features we estimate an rms emittance value for each of the two components.Comment: 25 pages, 10 figures; accepted for publication in PRSTAB; minor formatting errors correcte

Vector electromagnetic theory of transition and diffraction radiation with application to the measurement of longitudinal bunch size

We have developed a novel method based on vector electromagnetic theory and Schellkunoff's principles to calculate the spectral and angular distributions of transtion radiation (TR) and diffraction radiation (DR) produced by a charged particle interacting with an arbitrary target. The vector method predicts the polarization and spectral angular distributions of the radiation at an arbitrary distance form the source, i.e. in both the near and far fields, and in any direction of observation. The radiation fields of TR and DR calculated with the commonly used scalar Huygens model are shown to be limiting forms of those predicted by the vector theory and the regime of validity of the scalar theory is explicitly shown. Calculations of TR and DR done using the vector model are compared to results available in the literature for various limiting cases and for cases of more general interest. Our theory has important applications in the design of TR and DR diagnostics particularly those that utilize coherent TR or DR to infer the longitudinal bunch size and shape. A new technique to determine the bunch length using the angular distribution of coherent TR or DR is proposed.Comment: 47 pages, 16 figures, accepted for publication in Phys. Rev. ST. Accel. and Beam