Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis

OBJECTIVE: To investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid angiopathy (CAA). METHODS: We performed a systematic review and international individual patient-data pooled analysis in patients with cSAH associated with probable or possible CAA diagnosed on baseline MRI using the modified Boston criteria. We used Cox proportional hazards models with a frailty term to account for between-cohort differences. RESULTS: We included 190 patients (mean age 74.5 years; 45.3% female) from 13 centers with 385 patient-years of follow-up (median 1.4 years). The risks of each outcome (per patient-year) were: ICH 13.2% (95% CI 9.9-17.4); recurrent cSAH 11.1% (95% CI 7.9-15.2); combined ICH, cSAH, or both 21.4% (95% CI 16.7-26.9), ischemic stroke 5.1% (95% CI 3.1-8) and death 8.3% (95% CI 5.6-11.8). In multivariable models, there is evidence that patients with probable CAA (compared to possible CAA) had a higher risk of ICH (HR 8.45, 95% CI 1.13-75.5, p = 0.02) and cSAH (HR 3.66, 95% CI 0.84-15.9, p = 0.08) but not ischemic stroke (HR 0.56, 95% CI 0.17-1.82, p = 0.33) or mortality (HR 0.54, 95% CI 0.16-1.78, p = 0.31). CONCLUSIONS: Patients with cSAH associated with probable or possible CAA have high risk of future ICH and recurrent cSAH. Convexity SAH associated with probable (vs possible) CAA is associated with increased risk of ICH, and cSAH but not ischemic stroke. Our data provide precise risk estimates for key vascular events after cSAH associated with CAA which can inform management decisions

Maize evapotranspiration and water-use efficiency in response to row spacing

Reduced row spacing has shown to increase maize (Zea mays L.) yield; however there are conflicting results on whether narrow rows increases maize crop evapotranspiration and/or water use efficiency. This work analyzes the response of maize yield, crop evapotranspiration (ET) and water use efficiency to reduced row spacing under different water and N regimes. Maize crops were grown at Balcarce, Argentina, during two seasons. Treatments included two water regimes (rain-fed and irrigated), two rows spacing (35 and 70 cm) and two rates of N (i.e., 180 kg N ha−1 or nonfertilized). Soil water content was measured through the growing seasons using a neutron probe, grain yield and shoot dry matter were determined at physiological maturity. Grain yield response to narrow rows ranged from 0 to 23%; it was higher for water limited (i.e., rain-fed crops) and/or N deficient crops (i.e., nonfertilized crops) and lower for crops with high N fertilization and irrigation. Narrow rows consistently increased (8%) crop ET during the initial stages of crop growth; and N fertilization did not influence ET response to reduced row spacing during this period. Initial differences in ET between row spacing treatments were diluted as the season progressed, and seasonal crop ET was not influenced by row spacing. Reduced row spacing increased water use efficiency for grain production up to 17%; increments were larger in N deficient crops and/or with water limitations but were negligible in N fertilized and irrigated crops.P. Barbieri, L. Echarte, A. Della Maggiora, V.O. Sadras, H. Echeverria and F.H. Andrad