Hacking the Non-Technical Brain: Maximizing Retention in a Core Introductory IT Course

Maximizing student retention of, and ability to apply, technical material in introductory information technology courses is a complex task, especially with respect to the general student population. This population struggles with the application of programming concepts in the time-constrained testing environment. Our study considers the implementation of daily quizzes in a core-curriculum information technology and programming course as a means to improve student concept retention and application. Between the first and second exams, the instructors implemented a series of high-frequency, no-risk quizzes. Of the four sections of the course that each instructor taught, two sections each were provided with the quizzes as the experimental group and two remained with the standard curriculum as the control. The results demonstrate the benefits of frequent, effortful recall on student performance in a core-curriculum information technology and programming course

A review of mid-frequency vibro-acoustic modelling for high-speed train extruded aluminium panels as well as the most recent developments in hybrid modelling techniques

Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regulator of this process, but its activation under normoxic conditions, termed pseudohypoxia, is not well documented. Here, using an integrative approach combining the first genome-wide mapping of chromatin binding for an endocytic adaptor, ARRB1, both in vitro and in vivo with gene expression profiling, we demonstrate that nuclear ARRB1 contributes to this metabolic shift in prostate cancer cells via regulation of HIF1A transcriptional activity under normoxic conditions through regulation of succinate dehydrogenase A (SDHA) and fumarate hydratase (FH) expression. ARRB1-induced pseudohypoxia may facilitate adaptation of cancer cells to growth in the harsh conditions that are frequently encountered within solid tumours. Our study is the first example of an endocytic adaptor protein regulating metabolic pathways. It implicates ARRB1 as a potential tumour promoter in prostate cancer and highlights the importance of metabolic alterations in prostate cancer

Unexpectedly high burden of rotavirus gastroenteritis in very young infants

<p>Abstract</p> <p>Background</p> <p>The highest incidence of rotavirus gastroenteritis has generally been reported in children 6-24 months of age. Young infants are thought to be partially protected by maternal antibodies acquired transplacentally or via breast milk. The purpose of our study was to assess the age distribution of children with confirmed community-acquired rotavirus gastroenteritis presenting to an urban referral hospital.</p> <p>Methods</p> <p>Children presenting to The Children's Hospital of Philadelphia with acute gastroenteritis have been monitored for the presence of rotavirus antigen in the stool by ELISA (followed by genotyping if ELISA-positive) since the 1994-95 epidemic season.</p> <p>Results</p> <p>Over the last 12 rotavirus seasons prior to the introduction of the pentavalent rotavirus vaccine in 2006, stool specimens from 1646 patients tested positive for community-acquired rotavirus infection. Gender or age was not recorded in 6 and 5 cases, respectively. Overall, 58% of the cases occurred in boys. G1 was the predominant VP7 serotype, accounting for 72% of cases. The median (IQR) age was 11 (5-21) months. A total of 790 (48%) cases occurred in children outside the commonly quoted peak age range, with 27% in infants <6 months of age and 21% in children >24 months of age. A total of 220 (13%) cases occurred during the first 3 months of life, and the highest number of episodes per month of age [97 (6%)] was observed during the second month of life.</p> <p>Conclusions</p> <p>The incidence of community-acquired rotavirus gastroenteritis monitored over 12 seasons in the prevaccine era at a major university hospital was nearly constant for each month of age during the first year of life, revealing an unexpectedly high incidence of symptomatic rotavirus disease in infants <3 months old. A sizeable fraction of cases occurred in children too young to have been vaccinated according to current recommendations.</p

Online model racing based on extreme performance

Racing algorithms are often used for offline model selection, where models are compared in terms of their average performance over a collection of problems. In this paper, we present a new racing algorithm variant, Max-Race, which makes decisions based on the maximum performance of models. It is an online algorithm, whose goal is to optimally allocate computational resources in a portfolio of evolutionary algorithms, while solving a particular problem instance. It employs a hypothesis test based on extreme value theory in order to decide, which component algorithms to retire, while avoiding unnecessary computations. Experimental results confirm that Max-Race is able to identify the best individual with high precision and low computational overhead. When used as a scheme to select the best from a portfolio of algorithms, the results compare favorably to the ones of other popular algorithm portfolio approaches. © 2014 is held by the owner/author(s)