Synthesis and biological evaluation of some novel quinoline based pyrimidine derivatives

965-973A rational approach has been adopted for the synthesis of novel series of 3-((6-(2-chloro-6-methoxyquinolin-3-yl)-4-aryl-1,6-dihydropyrimidin-2-yl)thio)propanenitriles 5a-o. The synthesized compounds have been evaluated for their in vitro antimicrobial activity. Compounds 5j-m display broad spectrum antibacterial activity against all the bacterial strains. Moreover, compound 5m is found to be the most potent antibacterial and antifungal agent. Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggest that potent antimicrobial activity of 5j-m is accompanied by low level of cytotoxicity