14 research outputs found

    MetaBasis: A web-based database containing metadata on software tools and databases in the field of bioinformatics

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    We have developed an integrated web-based relational database information system, which offers an extensive search functionality of validated entries containing available bioinformatics computing resources. This system, called MetaBasis, aims to provide the bioinformatics community, and especially newcomers to the field, with easy access to reliable bioinformatics databases and tools. MetaBasis is focused on non-commercial and open-source software tools. © 2006 Adis Data Information BV. All rights reserved

    Development of a fluorescence-based imaging system for colon cancer diagnosis using two novel rhodamine derivatives

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    Tissue characterisation by endoscopic fluorescence imaging of exogenous fluorophores appears to be a promising method for cancer detection. Cationic and lipophilic fluorescence compounds of the aminoxanthene chemical family, have been found to exhibit selective accumulation in various carcinoma cells. In this paper the development of an endoscopic fluorescence-based imaging system with the additional capability of collecting emission spectra is described, which was used with two novel fluorescent probes rhodamine B-leucine amide and rhodamine B-phenyl boronic acid, for colon cancer diagnosis, in ex vivo tissue samples. Fluorescence images of human colon tissue revealed a remarkable differentiation of cancerous, from healthy colonic mucosa, confirmed by histopathology studies. These results from fluorescence imaging of colonic tissue were in total correspondence with the information extracted from the collection of fluorescence spectra
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