PREPARATIONS BASED ON WOOD-DECAY FUNGI

There is a large variety of basidiomycetes in the world including xylotrophicfungi which pharmacological properties are scarcely studied. So they are a promising research object for pharmacology, biotechnology, medicine, and veterinary medicine. This paper considers ways to create medicines based on wood-destroying fungi, producing pronounced immune stimulating effect, antimicrobial, antioxidant, antitumor activity

MONITORING OF BACTERIAL AGENTS - ETIOLOGICAL FACTORS OF MASS GASTRO-INTESTINAL DISEASES OF YOUNG POULTRY

The work presents the results of epizootological monitoring of mass gastro-intestinal diseases of young poultry in the Irkutsk Region. As a result of the poultry sickness rate analysis covering the period, of 2006-2010 the following nosological units have been distinguished: colibacteriosis (37,3 %), salmonellosis (25,4 %), pasteurellosis (19,8 %), spirochetosis (14,4 %), staphylococcus diseases (2,9 %), infectiouslaryngotracheitis (0,2 %). The results of the monitoring research, indicated that gastro-intestinal diseases are caused, by a wide range of opportunistic pathogenic microflora agents. However, these bacteria groups are mostly represented by microorganisms Enterobacteriaceae family of Escherichia and Salmonella types. The research established not only wide diversity of the distinguished serological colon bacillus and. salmonella varieties, but also fluctuations in their proportion in the common structure of the distinguished culture in the examined time interval

EXPERIMENTAL ASSESSMENT OF THE EFFICIENCY OF THE TRAMETIN AT EXPERIMENTAL SALMONELLOSIS OF LABORATORY AND AGRICULTURAL ANIMALS

Both clinical observation of animals and data of laboratory researches testify to the fact that veterinary medicine Trametin has high prophylactic efficacy at experimental salmonellosis in mice and in on-the-farm conditions in pigs. At the introduction of the medicine in an optimal dose while modelling dark stress we observed an increase in weight gains. The results of laboratory studies showed an increase in the protein content in blood serum, an increase in the content of phosphorus and calcium, an increase in hemoglobin and red blood cells. Phagocytic activity of piglets' blood in the group that received Trametin increased by 25 % in comparison with control values

Research of antioxidant and antimicrobial activity of aqueous alcoholic extracts from mycothallus and mycelium of Inonotus rheades (pers.) Bondartsev & Singer

We analyzed antioxidant and antimicrobial activity of aqueous alcoholic extracts from mycothallus and mycelium of Inonotus rheades. It was found that 70% aqueous alcoholic extracts from mycelium of I. rheades had the biggest antioxidant activity. 30% aqueous alcoholic extracts from mycothallus and mycelium have antimicrobial activity against the variety of microorganisms (Salmonella еnteritidis IMVL, Enterococcus faecalis ATSS 29217, Salmonella Ngor IMVL, Streptococcus spp. 44, Staphylococcus aureus ATSS 209p, Escherichia coli ATSS3 5218, Escherichia coli TI). We determined fungistatic activity of 30% aqueous alcoholic extracts of mycelium against Saccharomyces cerevisiae

Management of oxidative stress in animals using preparation based on Trametes pubescens

It has been determined that exposure to different stressors is associated with the development of oxidative stress, both in animals and in humans. The antioxidant defense system resists the development of oxidative stress. Basidiomycetes are the producers of a variety of biologically active compounds, including triterpene acids, exopolysaccharides, etc. Products derived from these species have immunostimulating, antitumor, antioxidant, antimetastatic action, and are effective for liver diseases treatment. The aim of the study, was to determine the antioxidant activity of Trametin to limit the stress-induced lipid peroxidation process. Antioxidant properties of Trametin (a product obtained by liquid-phase cultivation of the xylotroph fungus Trametes pubescens) were studied under experimental stress (decrease of the lighting intensity in piglets). 1t has been found that Trametin serves as an effective prevention of oxidative stress in stress conditions. 1t increases the level of unsaturation of lipids, reduces the concentration of primary and end products of lipid peroxidation, and also increases the total antioxidant activity of the blood, the activity of superoxide dismutase and reduces the glutathione level. Thus, the study of the effect of the preparation obtained by liquid-phase fermentation from fungus xylotroph of the genus Trametes pubescens showed a pronounced antioxidant effect on the model of dark stress in experimental animals, which can serve as a basis for its further application in veterinary and clinical medicine

Homeostasis of Brain Dynamics in Epilepsy: A Feedback Control Systems Perspective of Seizures

In an effort to understand basic functional mechanisms that can produce epileptic seizures, some key features are introduced in coupled lumped-parameter neural population models that produce “seizure”-like events and dynamics similar to the ones during the route of the epileptic brain towards seizures. In these models, modified from existing ones in the literature, internal feedback mechanisms are incorporated to maintain the normal low level of synchronous behavior in the presence of coupling variations. While the internal feedback is developed using basic feedback systems principles, it is also functionally equivalent to actual neurophysiological mechanisms such as homeostasis that act to maintain normal activity in neural systems that are subject to extrinsic and intrinsic perturbations. Here it is hypothesized that a plausible cause of seizures is a pathology in the internal feedback action; normal internal feedback quickly regulates an abnormally high coupling between the neural populations, whereas pathological internal feedback can lead to “seizure”-like high amplitude oscillations. Several external seizure-control paradigms, that act to achieve the operational objective of maintaining normal levels of synchronous behavior, are also developed and tested in this paper. In particular, closed-loop “modulating” control with predefined stimuli, and closed-loop feedback decoupling control are considered. Among these, feedback decoupling control is the consistently successful and robust seizure-control strategy. The proposed model and remedies are consistent with a variety of recent observations in the human and animal epileptic brain, and with theories from nonlinear systems, adaptive systems, optimization, and neurophysiology. The results from the analysis of these models have two key implications, namely, developing a basic theory for epilepsy and other brain disorders, and the development of a robust seizure-control device through electrical stimulation and/or drug intervention modalities