Repeated supra-maximal sprint cycling with and without sodium bicarbonate supplementation induces endothelial microparticle release

Under normal homeostatic conditions, the endothelium releases microparticles (MP), which are known to increase under stressful conditions and in disease states. CD105 (endoglin) and CD106 (vascular cell adhesion molecule-1) are expressed on the surface of endothelial cells and increased expression in response to stress may be observed. A randomised-controlled double-blinded study aimed to examine the use of endothelial microparticles as a marker for the state of one’s endothelium, as well as whether maintaining acid-base homeostasis affects the release of these MP. This study tested seven healthy male volunteers, who completed a strenuous cycling protocol, with venous blood analysed for CD105+ and CD106+ MP by flow cytometry at regular intervals. Prior to each trial participants consumed either 0.3 g·kg-1 body mass of sodium bicarbonate (NaHCO3), or 0.045 g·kg-1 body mass of sodium chloride (NaCl). A significant rise in endothelial CD105+MP and CD106+MP (p < 0.05) was observed at 90 minutes post exercise. A significant trend was shown for these MP to return to resting levels 180 minutes post exercise in both groups. No significance was found between experimental groups, suggesting that maintaining acid-base variables closer to basal levels has little effect upon the endothelial stress response for this particular exercise mode. In conclusion, strenuous exercise is accompanied by MP release and the endothelium is able to rapidly recover in healthy individuals, whilst maintaining acid-base homeostasis does not attenuate the MP release from the endothelium after exercise

Implications of a pre-exercise alkalosis-mediated attenuation of HSP72 on its response to a subsequent bout of exercise

The aim of this study was to investigate if a pre-exercise alkalosis-mediated attenuation of HSP72 had any effect on the response of the same stress protein after a subsequent exercise. Seven physically active males [25.0 ± 6.5 years, 182.1 ± 6.0 cm, 74.0 ± 8.3 kg, peak aerobic power (PPO) 316 ± 46 W] performed a repeated sprint exercise (EXB1) following a dose of 0.3 g kg⁻¹ body mass of sodium bicarbonate (BICARB), or a placebo of 0.045 g kg⁻¹ body mass of sodium chloride (PLAC). Participants then completed a 90-min intermittent cycling protocol (EXB2). Monocyte expressed HSP72 was significantly attenuated after EXB1 in BICARB compared to PLAC, however, there was no difference in the HSP72 response to the subsequent EXB2 between conditions. Furthermore there was no difference between conditions for measures of oxidative stress (protein carbonyl and HSP32). These findings confirm the sensitivity of the HSP72 response to exercise-induced changes in acid–base status in vivo, but suggest that the attenuated response has little effect upon subsequent stress in the same day

Pengaruh Kepemilikan Manajerial, Kepemilikan Institusional dan Kepemilikan Keluarga terhadap Manajemen Laba (Earning Management) pada Perusahaan Berkepemilikan Ultimat yang Terdaftar di Bei

This research aims to investigate the effect of managerial ownerships,institutional ownerships and family ownerships components to earnings management on the ultimate ownerships companies in Indonesian Stock Exchange.Data is used in this research is secondary data from monetary data inIndonesian Stock Exchange. The sample method used was purposive sampling. From the all of ultimate ownerships companies listed in the Indonesian Stock Exchange, research sample counted 60 companies that meet criteria. Hypothesis testing is done by using multiple linear regression analysis.The result of this research base on hypothesis test show that managerialownerships and institutional ownerships does not have significant effect with earnings management, while family ownerships have significant effect with earnings management. The magnitude of the effect (Adj R-Square) of managerial ownerships, institutional ownerships, and family ownerships on earnings management was 10,10%. While the remaining 80,90% is influenced by other variables.Keyword: managerial ownerships, institutional ownerships, family ownerships, earnings management, ultimate ownerships

Pengaruh Partisipasi Penyusunan Anggaran terhadap Kinerja Aparat Pemerintah Daerah Kab. Rokan Hilir dengan Gaya Kepemimpinan, Desentralisasi dan Komitmen Organisasi sebagai Variabel Moderating (Studi Empiris pada SKPD Kab. Rokan Hilir)

The purpose of this study to test empirically to related effect of budgetparticipation on the performance of local government officials with leadership style, decentralization and organizational commitment as a moderating variable in the district Kab. Rokan Hilir. Data collected by distributing questionnaires to the respondents. Population used in this study were all echelon II, III and IV in 15 work units (SKPD) in Kab. Rokan Hilir. The analytical method used is multiple regression wearing T-test using SPSS 17.00. The result of this study it is conclouded that in partial budget participation has an influence on the performance of local government officials. The result of the second test for inteeraction and leadership style also suggest that the effect on the relationship between budgetary participation and performance local government. And for the result of the decentralization variable interactions are also significant effect on the relationship of participation and performance of local government officials. Interaction and ttest result, which showed that the four organizational commitment can not moderate the relationship between budget participation on the performance of local government officials.Keywords : Budget Participation, Leadership Style, Decentralization, andOrganizational Commitmen

Pengaruh Sistem Pengukuran Kinerja Strategis terhadap Kinerja Manajerial, Kejelasan Peran dan Konflik Peran sebagai Mediasi (Survei pada Bank di Pekanbaru)

This study aimed to examine the effect of strategic performance measurement systems on managerial performance with clarity of roles and conflict mediation role as a banking enterprise in the city of Pekanbaru.Population in this research is all the banks in the city of Pekanbaru to sample the lower and middle level managers. Methods of data collection using questionnaires. Analysis of the data in this study using the Partial Least Square (PLS).Results of hypothesis testing in this study suggests that strategic performance measurement system has a positive effect on role conflict, strategic performance measurement system has a significant positive effect on role clarity, role conflict had no significant effect on the performance of manjerial, role clarity has no significant effect on managerial performance, strategic performance measurement system has a significant positive effect on managerial performance, and clarity of roles and role conflict did not mediate the relationship between strategic performance measurement systems on managerial performance.Keywords: managerial performance, strategic performance measurement systems, role clarity, role conflict

Pengaruh Partisipasi Anggaran terhadap Senjangan Anggaran dengan Informasi Asimetri, Budaya Organisasi, Komitmen Organisasi,dan Ketidakpastian Lingkungan sebagai Variabel Moderating (Studi Empiris pada SKPD Kab. Pelalawan)

The purpose of the research was examined the effect of budgetary participation on budgetary slack using information asymetry, organizational participation on budgetary slack using information asymetry, organizational culture, organizational commitment, and environmental uncertainty as culture, organizational commitment, and environmental uncertainty as moderating variabels. Population is the Regional Working Units (SKPD) in Pelalawan. Data collected by distributing questionnaires to the respondents.This research use multiple regression analysis model by (Statistical Product Service Solution) version 17.0. The results show that the first hypothesis budgetary participation and significant positive impact on budgetary slack. Furthermore, the second hypothesis, three and four information asymmetry, organizational culture, organizational commitment and the moderating effect significant relationship with the budgetary participation budgetary slack. The fifth hypothesis failed environmental uncertainty moderate the relationship between budgetary participation and budgetary slack. moderating variabels. Population is the Regional Working Units (SKPD) in Pelalawan. Data collected by distributing questionnaires to the respondents.This research use multiple regression analysis model by (Statistical Product Service Solution) version 17.0. The results show that the first hypothesis budgetary participation and significant positive impact on budgetary slack. Furthermore, the second hypothesis, three and four information asymmetry, organizational culture, organizational commitment and the moderating effect significant relationship with the budgetary participation budgetary slack. The fifth hypothesis failed environmental uncertainty moderate the relationship between budgetary participation and budgetary slack. Keyword :budgetary Participation, information asymetry, organizational Keyword :budgetary Participation, information asymetry, organizational culture, organizational commitment, environmental uncertainty, budgetary slack. culture, organizational commitment, environmental uncertainty, budgetary slack

Pengaruh Partisipasi dalam Penganggaran dan Peran Manajerial Pengelola Keuangan Daerah terhadap Kinerja Pemerintah Daerah (Studi Empiris pada SKPD Kabupaten Rokan Hulu)

This study aimed to examine the effect of participation in budgeting and financial management managerial roles with the object of the entire study area SKPDs Rokan Hulu district, consist of 25 SKPD. The research sample are 100 respondents consisting of 13 heads of department, 30 head of sector, 27 head subsections, and 1 hospital director in Rokan Hulu district. Data collected by distributing questionnaires. From 100 questionnaires sent, there were 74 respondents who returns the queationnaires and only 70 questionnaires that can be processed and analyzed. sampling techniques using simple random sampling. The method of data collection is by distributing questionnaires. Analysis using multiple regression. The results of this study we concluded that participation in budgeting and financial management managerial role area significantly positive effect on the performance of local government. In this study the magnitude of the effect that the R2 of 0.230 or 23% indicated that participation in budgeting and financial management managerial roles affect the performance of the local government area by 23%. The results of this study support previous studies.Keywords: Participation in Budgeting, Managerial Role of Financial Management The Local Government Performance