The Wide-field Spectroscopic Telescope (WST) Science White Paper

The Wide-field Spectroscopic Telescope (WST) is proposed as a new facility dedicated to the efficient delivery of spectroscopic surveys. This white paper summarises the initial concept as well as the corresponding science cases. WST will feature simultaneous operation of a large field-of-view (3 sq. degree), a high multiplex (20,000) multi-object spectrograph (MOS) and a giant 3x3 sq. arcmin integral field spectrograph (IFS). In scientific capability these requirements place WST far ahead of existing and planned facilities. Given the current investment in deep imaging surveys and noting the diagnostic power of spectroscopy, WST will fill a crucial gap in astronomical capability and work synergistically with future ground and space-based facilities. This white paper shows that WST can address outstanding scientific questions in the areas of cosmology; galaxy assembly, evolution, and enrichment, including our own Milky Way; origin of stars and planets; time domain and multi-messenger astrophysics. WST's uniquely rich dataset will deliver unforeseen discoveries in many of these areas. The WST Science Team (already including more than 500 scientists worldwide) is open to the all astronomical community. To register in the WST Science Team please visit https://www.wstelescope.com/for-scientists/participat

Characteristics and distribution of trulli constructions in the area of the site of community importance Murgia of Trulli

The agro-forestry territory in the Region of Apulia, southern Italy, is characterised by a widespread and diversified presence of dry stone constructions, including trulli, rural buildings with a characteristic a conical shape. The trulli are mainly to be found in the central and eastern part of the region, called Murgia of Trulli. Trulli are perfectly integrated with the agro-environment specificity of the area, creating a unique landscape and establishing themselves as a testimony of tradition and rural culture. In fact, in this area, from the 17th until the mid- 20th century, the trulli accompanied the development of agricultural activities. According to the number of cones they had, they were used as temporary shelters, places of support for primary production, or comfortable houses for the rural population. In recent decades, for several social and economic reasons, this heritage of rural buildings has been affected by abandonment and degradation phenomena. Interventions aimed at recovery and re-use have not always respected the origin of the buildings, their design characteristics or the landscape in which they had been built. In order to reduce the impact that this situation has had on environmental and territorial quality it is, therefore, necessary to develop initiatives to protect and valorise the trulli while respecting the identity of place, the architectural elements, and the agricultural and environmental characteristics of the territory. For this purpose, we need to analyse and characterise the heritage of the existing trulli and its relationship with the local reality. The present paper analyses the typology and distribution of the trulli located on the site of community importance Murgia of Trulli, a protected area with high environmental value in the central-eastern area of the Region of Apulia. Specifically, we analysed the relationship between the trulli buildings and the agro-environment context to acquire a basic interpretative knowledge in order to define strategies for recovery and re-use

Complexities of Genetic Counseling for ALS: A Case of Two Siblings with Discordant Genetic Test Results.

Rapid advances in the genetics of amyotrophic lateral sclerosis (ALS) have dramatically changed the approach of clinicians and researchers to the motor neuron diseases. We report two siblings in whom the genetic study provided conflicting results, hence raising a number of issues which deserve to be considered by clinicians involved in genetic testing for ALS. The first patient died within 2 years of ALS onset, while her brother still manages to walk unaided, 7 years into onset. Genetic analyses, performed on the first patient as part of a research protocol, and as clinical genetic testing on the brother, provided different results. Results for Patient 1 were negative for all investigated genes, thus suggesting that her disease may be a phenocopy, while her brother carried an autosomal dominant TARDBP mutation (p.A382T). A multidisciplinary approach may help patients and clinicians face the emerging dilemmas in such a complex field. Sharing and updating of advances, not to mention uncertainties inherent to current knowledge, with patients and families may prove to be an effective way to support them and to make them aware of the present limits of our knowledge and of the blurred border between research and clinical practice