36 research outputs found
A Lorentz-invariant look at quantum clock synchronization protocols based on distributed entanglement
Recent work has raised the possibility that quantum information theory
techniques can be used to synchronize atomic clocks nonlocally. One of the
proposed algorithms for quantum clock synchronization (QCS) requires
distribution of entangled pure singlets to the synchronizing parties. Such
remote entanglement distribution normally creates a relative phase error in the
distributed singlet state which then needs to be purified asynchronously. We
present a fully relativistic analysis of the QCS protocol which shows that
asynchronous entanglement purification is not possible, and, therefore, that
the proposed QCS scheme remains incomplete. We discuss possible directions of
research in quantum information theory which may lead to a complete, working
QCS protocol.Comment: 5 pages; typeset in RevTe
Fundamental Limits on the Speed of Evolution of Quantum States
This paper reports on some new inequalities of
Margolus-Levitin-Mandelstam-Tamm-type involving the speed of quantum evolution
between two orthogonal pure states. The clear determinant of the qualitative
behavior of this time scale is the statistics of the energy spectrum. An
often-overlooked correspondence between the real-time behavior of a quantum
system and the statistical mechanics of a transformed (imaginary-time)
thermodynamic system appears promising as a source of qualitative insights into
the quantum dynamics.Comment: 6 pages, 1 eps figur
Mutations in GABRB3
Objective: To examine the role of mutations in GABRB3 encoding the b3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. Methods: We performed massive parallel sequencing of GABRB3 in 416 patients with a range of epileptic encephalopathies and childhood-onset epilepsies and recruited additional patients with epilepsy with GABRB3 mutations from other research and diagnostic programs. Results: We identified 22 patients with heterozygous mutations in GABRB3, including 3 probands frommultiplex families. The phenotypic spectrum of the mutation carriers ranged from simple febrile seizures, genetic epilepsies with febrile seizures plus, and epilepsy withmyoclonic-atonic seizures to West syndrome and other types of severe, early-onset epileptic encephalopathies. Electrophysiologic analysis of 7 mutations in Xenopus laevis oocytes, using coexpression of wild-type or mutant beta(3), together with alpha(5) and gamma(2s) subunits and an automated 2-microelectrode voltage-clamp system, revealed reduced GABA-induced current amplitudes or GABA sensitivity for 5 of 7 mutations. Conclusions: Our results indicate that GABRB3 mutations are associated with a broad phenotypic spectrum of epilepsies and that reduced receptor function causing GABAergic disinhibition represents the relevant disease mechanism
Coccidian Infection Causes Oxidative Damage in Greenfinches
The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. We tested this hypothesis in experimental coccidian infection model in greenfinches Carduelis chloris. Administration of isosporan coccidians to experimental birds did not affect indices of antioxidant protection (TAC and OXY), plasma triglyceride and carotenoid levels or body mass, indicating that pathological consequences of infection were generally mild. Infected birds had on average 8% higher levels of plasma malondialdehyde (MDA, a toxic end-product of lipid peroxidation) than un-infected birds. The birds that had highest MDA levels subsequent to experimental infection experienced the highest decrease in infection intensity. This observation is consistent with the idea that oxidative stress is a causative agent in the control of coccidiosis and supports the concept of oxidative costs of immune responses and parasite resistance. The finding that oxidative damage accompanies even the mild infection with a common parasite highlights the relevance of oxidative stress biology for the immunoecological research