Calculation and experimental evaluation of bogie frame and intermediate frame life of an eight-axle diesel locomotive

Introduction. Long-term locomotive operation and safety considerations require new approaches to extending the life of its basic components operating under variable loads.Materials and methods. The authors conducted bench life tests of frames under cyclic loading with vertical and horizontal transverse forces and calculated the bogie frame and intermediate frame life for the most stressed areas of their structures, where local fatigue damage can accumulate under cyclic loading leading to fatigue caused destruction. The calculation uses the results of bench fatigue tests.Results. The research shows that the presented frames comply with GOST R 55513–2013 in terms of minimum reserve strength coefficient for fatigue resistance. The researchers proposed a methodology for estimating the residual life of bogie frames and intermediate frames.Discussion and conclusion. The research indicates that the estimated safe service life of bogie frames and intermediate frames of an eight-axle diesel locomotive does not exceed 56 years from the date of construction. The expiry of this period allows for a repeat research and development work to determine the residual life of its basic parts. The above test methodology could be applied to assess the residual life of bogie frames and intermediate frames whose structure has localised zones of fatigue damage appearance and accumulation from cyclic loading, which may cause fatigue destruction

Клинический случай успешного лечения тяжелого рефрактерного подагрического артрита

Цель данной работы — демонстрация дополнительных возможностей лечения тяжелого рефрактерного подагрического артрита, для чего мы приводим клинический случай. Пациент находился на стационарном лечении в терапевтическом отделении Центра реконструктивной и восстановительной медицины (университетская клиника) Одесского национального медицинского университета по поводу тяжелого рефрактерного подагрического артрита, полиартрита с поражением обоих голеностопных суставов, лучезапястных суставов, мелких суставов кистей и стоп. После неудачных попыток лечения пациента «стандартными» методами, мы успешно применили пульс-терапию метилпреднизолоном. Лечение подагрического артрита остается сложной задачей, решение которой требует комплексного подхода с учетом многих факторов, в том числе индивидуальной реакции на назначаемую терапию. Пульс-терапия метилпреднизолоном может быть эффективной в лечении тяжелого острого рефрактерного подагрического артрита.The purpose of this work was to demonstrate additional treatment options for severe refractory gouty arthritis. To achieve this goal we present a clinical case. The patient was on inpatient treatment at the Therapeutic Department of the Center of Reconstructive and Restorative Medicine (University Clinic) of the Odessa National Medical University due to severe refractory gouty arthritis, polyarthritis with injury of both ankle joints, wrist and small joints of the hands and feet. In order to treat the acute attack of gouty arthritis in this patient, we consistently used: colchicine, different non-steroidal anti-inflammatory drugs, glucocorticosteroids in mild-to-moderate doses and different analgetics. After unsuccessful attempts to treat the patient with standard methods, we successfully applied pulsed therapy with methylprednisolone. Treatment of gouty arthritis remains a complex task, the solution of which requires an integrated approach taking into account many factors, including individual response to the prescribed therapy. Pulse therapy with methylprednisolone can be effective in treating severe acute refractory gouty arthritis

Комплексное обследование и лечение пациента с инфарктом миокарда IV типа с использованием высокочувствительного экспресс-теста на тропонин І

Исследование уровней сердечного тропонина служит «золотым стандартом» для диагностики острого коронарного синдрома и инфаркта миокарда. Цель исследования — оценить возможность сокращения времени диагностики острого поражения миокарда за счет использования экспресс-теста на тропонин І производства ООО «Виробнича фірма Сіместа». Для сравнения разницы в динамике результатов экспресс-тестов на тропонин І разными методиками приведен клинический случай пациента с острым инфарктом миокарда. Использование высокочувствительного теста на тропонин І производства ООО «Виробнича фірма Сіместа» может быть перспективным в качестве метода ранней диагностики инфаркта миокарда для уменьшение времени до проведения процедуры реваскуляризации.The measurement of cardiac troponin levels is a gold standard of the diagnosis of acute coronary syndrome and myocardial infarction. Qualitative tests of troponins begin to implement in clinical practices in Ukraine. Unfortunately there is a lack of standardization of monoclonal antibodies on which the quantitative determination of troponins are based, item the tests of different manufacturers have various absolute values of concentration, sensitivity, specificity and significant levels for diagnosis. Furthermore, immune enzyme analyzers of different manufacturers are used in a clinic. Such situation complicates the clinician’s decision for earlier diagnosis of acute coronary syndrome and estimation of time-dependent dynamics of the troponin levels. The aim of the study was to evaluate the possibility of reducing the time of diagnosis of acute myocardial injury by using the express test for troponin І produced by LLC “Virobnicha firma Simesta”, Ukraine. To compare the differences in time-dependent dynamics of two differ express tests of the troponin І, the clinical case of the patient with acute myocardial infarction of the IV type is demonstrated. The using of Troponin I high-sensitivity rapid assay produced by LLC "Virobnicha firma Simesta", Ukraine, may have some perspectives as a method of earlier diagnosis of myocardial infarction to reduce the time prior to revascularization procedure

CUSTOMS DEVELOPMENT STRATEGY: COMPARATIVE ANALYSIS

This article discusses approaches to conducting a comparative analysis of alternative solutions to the problem of forming a development strategy in government structures. The article defines the conditions for the examination of the results of strategic planning in the customs authorities of Russia. The structure of the Development Strategy of the Russian Customs Service until 2030 is analyzed.</jats:p

On the question of the value of agglutinating serums

Agglutinating sera, as a means for determining the physiognomy of this or that microorganism, took one of the first places in microbiology.</jats:p

The simulation of crack growth in rolling stock running wheel disk

Abstract The article reviews scientific and technical literature in the field of the survivability of railway wheels. The computer simulation of the flat crack growth at different temperatures is performed with the estimation of the crack propagation rate and survivability parameters. In conclusion, the estimation is provided to refine the calculation model, followed by the recalculation of the obtained results.</jats:p