99 research outputs found
Modular plastic chip for one-shot human papillomavirus diagnostic analysis.
In this article, we report the design and development of a plastic modular chip suitable for one-shot human papillomavirus (HPV) diagnostics, namely detection of the viral presence and relative genotyping, by two sequential steps performed directly on the same device. The device is composed of two modular and disposable plastic units that can be assembled or used separately. The first module is represented by a polydimethylsiloxane (PDMS) microreactor that is exploited for real-time polymerase chain reaction (PCR) and, thus, is suitable for detecting the presence of virus. The second unit is a PDMS microwell array that allows virus genotyping by a colorimetric assay, based on DNA hybridization technology developed on plastic, requiring simple inspection by the naked eye. The two modules can be easily coupled to reusable hardware, enabling the heating/cooling processes and the real-time detection of HPV. By coupling real-time assay and colorimetric genotyping on the same chip, the assembled device may provide a low-cost tool for HPV diagnostics, thereby favoring the prediction of cancer risk in patients
Sudden massive neck swelling due to hemorrhage of a thyroid adenoma: a case report
<p>Abstract</p> <p>Introduction</p> <p>Sudden swelling of the neck is an emergency situation that can be life-threatening for the patient. Therefore, an understanding of the possible underlying pathology is of great importance. Sudden massive swelling of the neck because of intralesional bleeding of a thyroid adenoma is seldom encountered but must be considered. Such massive swelling caused by spontaneous bleeding of a thyroid adenoma has not yet been described in the literature.</p> <p>Case presentation</p> <p>We report the case of a 71-year-old Caucasian man with sudden massive neck swelling due to intralesional bleeding of a thyroid adenoma. We present his clinical history, physical examination results, computed tomography (CT) scans, and histological findings after surgery. He presented with sudden massive swelling of the left side of his neck after sneezing while working with his hands over his head. An ear, nose, and throat examination showed a painless swelling of the left side of his neck and a displacement of his larynx to the right. CT scans revealed a mass originating from the left lobe of his thyroid gland and the mass displaced his larynx and trachea. A surgical exploration showed a greatly enlarged left lobe of his thyroid gland. A histopathological examination showed a hemorrhagic infarction of a follicular thyroid adenoma.</p> <p>Conclusions</p> <p>Sudden intralesional bleeding of a thyroid adenoma is a rare condition but one that should be considered in cases of sudden and massive swelling of the neck.</p
Noncommutative Differential Forms on the kappa-deformed Space
We construct a differential algebra of forms on the kappa-deformed space. For
a given realization of the noncommutative coordinates as formal power series in
the Weyl algebra we find an infinite family of one-forms and nilpotent exterior
derivatives. We derive explicit expressions for the exterior derivative and
one-forms in covariant and noncovariant realizations. We also introduce
higher-order forms and show that the exterior derivative satisfies the graded
Leibniz rule. The differential forms are generally not graded-commutative, but
they satisfy the graded Jacobi identity. We also consider the star-product of
classical differential forms. The star-product is well-defined if the
commutator between the noncommutative coordinates and one-forms is closed in
the space of one-forms alone. In addition, we show that in certain realizations
the exterior derivative acting on the star-product satisfies the undeformed
Leibniz rule.Comment: to appear in J. Phys. A: Math. Theo
Incidence of dental caries in primary dentition and risk factors: a longitudinal study
Effect of a low dose whey/guar preload on glycemic control in people with type 2 diabetes-a randomised controlled trial
Applicability of Moringa oleifera Lam. pie as an adsorbent for removal of heavy metals from waters
Estudo da adsorção de surfactante catiônico em uma matriz inorgânica preparada via óxido de nióbio
Preparação e caracterização de materiais híbridos celulose/NbOPO4.nH2O a partir de celulose branqueada de bagaço de cana-de-açúcar
Metabolic effects of diet Guar-Gum supplementation on glucose production, metabolic clearance rate of glucose, insulin binding, and lipid profile in Type II (non-insulin-dependent) diabetic patients.
- …