A case of idiopathic edema after opioid abuse cessation: can failed aldosterone escape be implicated?

Edema is a recognized complication of ongoing heavy opioid use, regardless of the means of delivery or the specifics of the drug in question. The mechanism responsible remains incompletely understood. Hypotheses currently offered include increased Anti-Diuretic Hormone (ADH) secretion, histamine-mediated permeability changes, independent opioid-receptor mediated fluid retention and an exacerbation of pre-existing vascular compromise. Authors report a case of a 39yr old lady in whom edema emerged 7 months after cessation of opioid abuse. All secondary causes of edema were excluded by an exhaustive battery of investigations. The edema failed to recede with loop diuretics, and resolved only on institution of spironolactone, on which she maintained improvement. This case study reinforces hypotheses of ADH likely mediating opioid associated edema and suggests that aldosterone receptor antagonists are probably a superior class of drugs in opioid-associated edema. It also suggests that the physiological changes caused by opioid use that are responsible for edema are likely stable and persist well beyond the period of actual use. Reformed opioid abusers who never received OST are a huge population whose unique physiological status is likely to yield valuable insights into not just the pathology of opioid-abuse related edema, but the pathology of opioid use as a whole

Tilt Detection Of Connectors Using Phase Shifting.

AVI’s are playing important roles in quality inspection in the electronic industry. Most existing AVIs are single overhead camera and are incapable detecting 3D defects. This work presents solving the shortcoming stated using an angle fringe projection

PERIODATE OXIDATION OF PEG–600, AN ESSENTIAL PHARMACEUTICAL POLYMER

Objective: To study the kinetics of periodate oxidation of polyethylene glycol-600 (PEG-600), a familiar non-toxic polymer used in pharmaceutical and other fields of industry. Methods: Reactions were carried out in alkaline medium and measured the kinetics by iodometry. One oxygen atom loss or two electrons transfer was observed per each molecule of periodate i.e., the rate of reaction was measured periodate converts to iodate because the formed iodate species is unable to oxidize the substrate molecules. Results: Based on log (a-x) versus t plots, order w. r. t. oxidant (periodate) is unity. Reactions were found to be independent of substrate (PEG-600) concentration. A decrease in rate with an increase in alkali concentration [OH–] was found and order was inverse fractional. Temperature dependence of reaction rate was studied and then calculated the corresponding Arrhenius parameters. Conclusion: An appropriate rate law was proposed by considering the above experimental results

Optimal preprocessing of WiFi CSI for sensing applications

Due to its ubiquitous and contact-free nature, the use of WiFi infrastructure for performing sensing tasks has tremendous potential. However, the channel state information (CSI) measured by a WiFi receiver suffers from errors in both its gain and phase, which can significantly hinder sensing tasks. By analyzing these errors from different WiFi receivers, a mathematical model for these gain and phase errors is developed in this work. Based on these models, several theoretically justified preprocessing algorithms for correcting such errors at a receiver and, thus, obtaining clean CSI are presented. Simulation results show that at typical system parameters, the developed algorithms for cleaning CSI can reduce noise by $40$% and $200$%, respectively, compared to baseline methods for gain correction and phase correction, without significantly impacting computational cost. The superiority of the proposed methods is also validated in a real-world test bed for respiration rate monitoring (an exemplary sensing task), where they improve the estimation signal-to-noise ratio by $20$% compared to baseline methods.Comment: Paper is currently under review at IEEE Transactions on Wireless Communication

Studies in the formation of heterocyclic rings containing nitrogen. Part V. The position of nitro group in the 1:2-disubstituted benziminazole from 4-nitro-o-phenylenediamine and benzaldehyde

1-benzyl-2-phenyl-5-nitro benziminazole and 1-benzyl-2-phenyl-6-nitro benziminazole have been synthesised starting from N-benzyl-2:4-dinitro aniline and 2:5-dinitro aniline respectively. The 1:2-disubstituted benziminazole obtained by the condensation of 4-nitro-o-phenylenediamine with benzaldehyde has been found to be identical with the 6-nitro benziminazole