Multimodal Therapy for the Treatment of Severe Ischemic Stroke Combining Endovascular Embolectomy and Stenting of Long Intracranial Artery Occlusion

Embolic occlusion of cerebral arteries is a major cause for stroke. Intravenous thrombolysis showed positive results in this condition, however even when strict criteria are used, the risk of hemorrhagic transformation is possible. Microsurgical embolectomy has been described earlier. Purpose. We performed multimodal therapy of cerebral artery occlusion. Case Report. We present a case of a 49-year-old female patient who—according to the National Institute of Health Stroke Scale (NIHSS)—was rated as 19 due to acute occlusion of the horizontal segment of the left middle cerebral artery (MCA). After failed i.v. thrombolysis, only a part of the clot could be evacuated by the endovascular approach—without restoration of blood flow. Normal patency of the left MCA was re-established after stenting. Within 72 hours, the patient had an NIHSS score of 14, with a small haematoma in the left hemisphere. Conclusion. In our case multimodal therapy combining i.v. thrombolysis, mechanical disruption of thrombus, MCA stenting and platelet function antagonists, resulted in successful recanalization of the acutely occluded left MCA

Investigating the effects of comprehensive smoke-free legislation on neonatal and infant mortality in Thailand using the synthetic control method

Background: Almost all of the evidence on the benefits of smoke-free legislation on child health comes from evaluations in high-income countries. We investigated the effects of Thailand’s 2010 comprehensive smokefree legi

Biocontrol of potato wilt by selective rhizospheric and endophytic bacteria associated with potato plant

Ralstonia solanacearum is the causative agent of wilt disease in plants, which constitutes a severe problem to agricultural crops, particularly for potato production in Madagascar. The present study focuses on the isolation, in vitro and in vivo assays of potential rhizospheric and endophytic bacteria associated with healthy potato plant, capable to inhibit the growth of Ralstonia solanacearum for controlling potato bacterial wilt. A total of 77 bacteria strains were isolated from six soil rhizospheric samples and six vegetal material samples of healthy potatoes in the district of Antsirabe II. Forty of them were telluric actinomycetes, 25 were endophytic actinomycetes and 12 were fluorescent Pseudomonas spp. An additional 30 phytopathogenic isolates were obtained from six rhizopsheric soil samples of diseased potatoes. Morphological, cultural, biochemical characterization and molecular identification with the Ralstonia solanacearum specific primers 759/760 revealed that 24 of the pathogenic isolates belong to the Ralstonia solanacearum species, biovar two; the causal agent of potato bacterial wilt. Isolates from healthy plants were, then, examined in vitro and in vivo for their antagonistic activity against Ralstonia solanacearum strain for their potential to improve potato plant growth. In vitro antagonism of actinomycete and Pseudomonas isolates against Ralstonia solanacearum development was performed using agar diffusion technique, while in vivo tests were conducted under greenhouse conditions. Ten antagonistic strains including two Pseudomonas, four telluric actinomycetes, and four endophytic actinomycetes inhibited the tested Ralstonia strain. Four strains, E7, E13 (endophytic actinomycete from root potatoes), S25 (telluric actinomycetes) and P7 (fluorescent Pseudomonas), showed high antagonistic activity against the pathogen with zones of inhibition from 23 to 40 mm. Of the fours strains tested in greenhouse, E7 significantly reduced (p < 0.05) the percentage of Ralstonia solanacearum that infected plants by 72.04%. The isolates E13 and S25 have also been demonstrated to improve plant growth by increase of plant height to 44.63% and 44.84%, fresh weight to 68.75% and 75.85% and dry weight to 86.17% and 115.42%, respectively compared with non-treated control. Morphological and cultural characterization of these three active isolates showed that they belong to the genus Streptomyces. The antagonism of these isolates against Ralstonia solanacearum according to in vitro and in vivo tests results, along with their high efficiency as regards the improvement of plant development, suggests that these three actinomycete strains E7, E13 and S25 could be useful for biocontrol of potato bacterial wilt.Key words: Potato, Ralstonia, Actinomycetes, Pseudomonas, Biocontrol

Socioeconomic inequalities in smoking and drinking in adolescence:social network dynamics

BackgroundNetwork-based interventions have the potential to prevent socioeconomic inequalities in health behaviors but require a good understanding of the underlying social network mechanisms. We investigated whether (1) adolescents selected friends with a similar socioeconomic status (SES), (2) smoking and alcohol consumption spread in networks, and (3) the exclusion of non-smokers or non-drinkers differed between SES groups.MethodsWe applied Stochastic Actor Oriented Models to the complete social network data (“Wired into Each Other” data) of 253 adolescents in eight Hungarian secondary school classes over three waves between 2010 and 2013. SES was measured based on entitlement to an income-tested regular child protection benefit.ResultsHigh SES adolescents were most likely to form friendships with peers from their own SES group (odds ratio [OR] = 1.1, 95% Confidence Interval [CI] = 1.0-1.1). Adolescents adjusted their smoking behavior (OR = 24.0, 95% CI 1.3-454.9) but not their alcohol consumption (OR = 1.6, 95% CI 0.6-4.4) to emulate the behavior of their friends. Smokers did not differ from non-smokers in the likelihood of receiving a friendship nomination (OR = 1.0, 95% CI 0.9-1.1), regardless of their SES. Alcohol consumers received significantly more friendship nominations than non-consumers (OR = 1.2, 95% CI 1.0-1.3), but this association was not significantly different according to SES.ConclusionsSocioeconomic inequalities in health behaviors were driven by preferences to form friendships within their own SES group and the spread of smoking and alcohol consumption in the network. These inequalities were not amplified by SES differences in encouraging smoking or drinking.Main messages: In three waves of observations in a Hungarian adolescent cohort, the study found social network effects for inequalities in smoking and alcohol consumption

Socioeconomic inequalities in smoking and drinking in adolescence:social network dynamics

BackgroundNetwork-based interventions have the potential to prevent socioeconomic inequalities in health behaviors but require a good understanding of the underlying social network mechanisms. We investigated whether (1) adolescents selected friends with a similar socioeconomic status (SES), (2) smoking and alcohol consumption spread in networks, and (3) the exclusion of non-smokers or non-drinkers differed between SES groups.MethodsWe applied Stochastic Actor Oriented Models to the complete social network data (“Wired into Each Other” data) of 253 adolescents in eight Hungarian secondary school classes over three waves between 2010 and 2013. SES was measured based on entitlement to an income-tested regular child protection benefit.ResultsHigh SES adolescents were most likely to form friendships with peers from their own SES group (odds ratio [OR] = 1.1, 95% Confidence Interval [CI] = 1.0-1.1). Adolescents adjusted their smoking behavior (OR = 24.0, 95% CI 1.3-454.9) but not their alcohol consumption (OR = 1.6, 95% CI 0.6-4.4) to emulate the behavior of their friends. Smokers did not differ from non-smokers in the likelihood of receiving a friendship nomination (OR = 1.0, 95% CI 0.9-1.1), regardless of their SES. Alcohol consumers received significantly more friendship nominations than non-consumers (OR = 1.2, 95% CI 1.0-1.3), but this association was not significantly different according to SES.ConclusionsSocioeconomic inequalities in health behaviors were driven by preferences to form friendships within their own SES group and the spread of smoking and alcohol consumption in the network. These inequalities were not amplified by SES differences in encouraging smoking or drinking.Main messages: In three waves of observations in a Hungarian adolescent cohort, the study found social network effects for inequalities in smoking and alcohol consumption

Analogues of the central point theorem for families with dd-intersection property in Rd\mathbb R^d

In this paper we consider families of compact convex sets in $\mathbb R^d$ such that any subfamily of size at most $d$ has a nonempty intersection. We prove some analogues of the central point theorem and Tverberg's theorem for such families

Theory of Non-Reciprocal Optical Effects in Antiferromagnets: The Case Cr_2O_3

A microscopic model of non-reciprocal optical effects in antiferromagnets is developed by considering the case of Cr_2O_3 where such effects have been observed. These effects are due to a direct coupling between light and the antiferromagnetic order parameter. This coupling is mediated by the spin-orbit interaction and involves an interplay between the breaking of inversion symmetry due to the antiferromagnetic order parameter and the trigonal field contribution to the ligand field at the magnetic ion. We evaluate the matrix elements relevant for the non-reciprocal second harmonic generation and gyrotropic birefringence.Comment: accepted for publication in Phys. Rev.

Complex-Orbital Order in Fe_3O_4 and Mechanism of the Verwey Transition

Electronic state and the Verwey transition in magnetite (Fe_3O_4) are studied using a spinless three-band Hubbard model for 3d electrons on the B sites with the Hartree-Fock approximation and the exact diagonalisation method. Complex-orbital, e.g., 1/sqrt(2)[|zx> + i |yz>], ordered (COO) states having noncollinear orbital moments ~ 0.4 mu_B on the B sites are obtained with the cubic lattice structure of the high-temperature phase. The COO state is a novel form of magnetic ordering within the orbital degree of freedom. It arises from the formation of Hund's second rule states of spinless pseudo-d molecular orbitals in the Fe_4 tetrahedral units of the B sites and ferromagnetic alignment of their fictitious orbital moments. A COO state with longer periodicity is obtained with pseudo-orthorhombic Pmca and Pmc2_1 structures for the low-temperature phase. The state spontaneously lowers the crystal symmetry to the monoclinic and explains experimentally observed rhombohedral cell deformation and Jahn-Teller like distortion. From these findings, we consider that at the Verwey transition temperature, the COO state remaining to be short-range order impeded by dynamical lattice distortion in high temperature is developed into that with long-range order coupled with the monoclinic lattice distortion.Comment: 16 pages, 13 figures, 6 tables, accepted for publication in J. Phys. Soc. Jp

Electric-field control of spin waves at room temperature in multiferroic BiFeO3

To face the challenges lying beyond current CMOS-based technology, new paradigms for information processing are required. Magnonics proposes to use spin waves to carry and process information, in analogy with photonics that relies on light waves, with several advantageous features such as potential operation in the THz range and excellent coupling to spintronics. Several magnonic analog and digital logic devices have been proposed, and some demonstrated. Just as for spintronics, a key issue for magnonics is the large power required to control/write information (conventionally achieved through magnetic fields applied by strip lines, or by spin transfer from large spin-polarized currents). Here we show that in BiFeO3, a room-temperature magnetoelectric material, the spin wave frequency (>600 GHz) can be tuned electrically by over 30%, in a non-volatile way and with virtually no power dissipation. Theoretical calculations indicate that this effect originates from a linear magnetoelectric effect related to spin-orbit coupling induced by the applied electric field. We argue that these properties make BiFeO3 a promising medium for spin wave generation, conversion and control in future magnonics architectures.Comment: 3 figure