Management of the Depressed Newborn; to Cool or Not to Cool

Hypoxic-ischaemic encephalopathy (HIE) is arguably the most important neurologic condition to affect term newborns with significant adverse sequelae including death and disability in survivors. Since mild therapeutic hypothermia has been shown to improve outcomes, the field has become highly energized with optimism and new research. Using a case study, the challenges of selecting babies for neuroprotection are explored. This is followed by a look at what is on the horizon including cooling outside of standard criteria, mild HIE and novel biomarkers