Inhibitors of Pyruvate Carboxylase

This review aims to discuss the varied types of inhibitors of biotin-dependent carboxylases, with an emphasis on the inhibitors of pyruvate carboxylase. Some of these inhibitors are physiologically relevant, in that they provide ways of regulating the cellular activities of the enzymes e.g. aspartate and prohibitin inhibition of pyruvate carboxylase. Most of the inhibitors that will be discussed have been used to probe various aspects of the structure and function of these enzymes. They target particular parts of the structure e.g. avidin – biotin, FTP – ATP binding site, oxamate – pyruvate binding site, phosphonoacetate – binding site of the putative carboxyphosphate intermediate

Formation of H3−_3^- by radiative association of H2_2 and H−^- in the interstellar medium

We develop the theory of radiative association of an atom and a diatomic molecule within a close-coupling framework. We apply it to the formation of H$_3^-$ after the low energy collision (below 0.5 eV) of H$_2$ with H$^-$. Using recently obtained potential energy and permanent dipole moment surfaces of H$_3^-$, we calculate the lowest rovibrational levels of the H$_3^-$ electronic ground state, and the cross section for the formation of H$_3^-$ by radiative association between H$^-$ and ortho- and para-H$_2$. We discuss the possibility for the H$_3^-$ ion to be formed and observed in the cold and dense interstellar medium in an environment with a high ionization rate. Such an observation would be a probe for the presence of H$^-$ in the interstellar medium

The Magellanic Bridge: The Nearest Purely Tidal Stellar Population

We report on observations of the stellar populations in twelve fields spanning the region between the Magellanic Clouds, made with the Mosaic-II camera on the 4-meter telescope at the Cerro-Tololo Inter-American Observatory. The two main goals of the observations are to characterize the young stellar population (which presumably formed in situ in the Bridge and therefore represents the nearest stellar population formed from tidal debris), and to search for an older stellar component (which would have been stripped from either Cloud as stars, by the same tidal forces which formed the gaseous Bridge). We determine the star-formation history of the young inter-Cloud population, which provides a constraint on the timing of the gravitational interaction which formed the Bridge. We do not detect an older stellar population belonging to the Bridge in any of our fields, implying that the material that was stripped from the Clouds to form the Magellanic Bridge was very nearly a pure gas.Comment: 19 pages, 9 figures. Accepted to Ap