Trodimenzijski matematički model taljenja čeličnog otpatka u konvertorskoj talini

Three - dimensional mathematical model of fusion of cubical steel scrap in the converter melt was developed. The model was solved using modified implicit Brian’s method. The obtained algorithm was programmed in ASCII FORTRAN for the computer SPERRY 1106. In the model temperature dependent thermo-physical properties of material were incorporated. That gives to the model a nonlinearity. On the basis of the model it was concluded that addition of 1% of low - carbon steel scrap decreases the temperature of a middle carbon steel melt for cca 23 °C. This is in good agreement with experimental data from literature. At the same time a new formula for the fusion time of steel scrap was developed, which enables to calculate the fusion time on the basis of the volume of the steel scrap in the converter melt.Trodimenzijski matematički model taljenja čeličnog otpatka u konvertorskoj talini. Razvijen je trodimenzijski matematički model taljenja kockastog čeličnog otpatka u konvertorskoj talini. Model je riješen korištenjem modificirane implicitne Brianove metode. Dobiveni algoritam prograimiran je u ASCII FORTRAN za računalo SPERRY 1106. U model su ugrađena temperaturno ovisna toplofizička svojstva materijala, što modelu daje nelinearnost. Na temelju modela zaključeno je da 1 % niskougljičnog čeličnog otpatka smanji temperaturu srednje ugljične taline za cca 23 °C, što se dobro slaže s eksperimentalnim podacima iz literature. Istodobno, dobivena je nova formula za vrijeme taljenja čeličnog otpatka, koja omogućuje računanje vremena taljenja u ovisnosti o volumenu čeličnog otpatka u konvertorskoj talini

DIFFERENCES IN QUALITY OF LIFE AFTER STROKE AND MYOCARDIAL INFARCTION

Introduction: There is obvious decline in quality of life after MI and stroke. The main factors that reduce quality of life in these patients were the inability of returning to normal activities, pain and the development of depression / anxiety. We wanted to know what has the biggest influence on recovery and differences in quality of life in patients after stroke and heart attack. Subjects and Methods: Cross-sectional study was conducted using HADS and WHOQOL-Bref questionnaire. Criteria for exclusion were diabetes, previous depression, cancer or other co morbidities that influenced the quality of life. It has been surveyed total of 396 patients, of whom 378 patients satisfied the criteria of inclusion in the study. Based on the personal data of patients, they were divided according to gender, age, educational level, and social support expressed by number of members with whom patient lives. Results: In all the observed parameters of the SU group had better results than the stroke group. The recovery after a stroke affected age, length of education and depression. Age, gender and length of education influence on a heart attack recovery. Disease duration did not affect the quality of life in either group. Significantly more patients after a stroke had depression compared to MI (p<0.001). Anxiety was not found significant in differences between groups (p=0.051). Metabolic syndrome was more frequent in the stroke group, but the difference between groups was not significant (stroke/MI) (p=0.098). In the group of stroke patients who had MS patients more often had depression (p=0.003) for different of respondents from the group with MI. Conclusion: Quality of life was significantly worse in patients after stroke compared to those with MI. The recovery from stroke was most significantly impacted by depression and age and level of education, while the recovery from heart attack was at most affected by gender, age and level of education

Novel Thieno [2,3-b]pyridine Anticancer Compound Lowers Cancer Stem Cell Fraction Inducing Shift of Lipid to Glucose Metabolism.

Due to the role of cancer stem cells (CSCs) in tumor resistance and glycosphingolipid (GSL) involvement in tumor pathogenesis, we investigated the effect of a newly synthesized compound (3-amino-N-(3-chloro-2-methylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide 1 on the percentage of CSCs and the expression of six GSLs on CSCs and non-CSCs on breast cancer cell lines (MDA-MB-231 and MCF-7). We also investigated the effect of 1 on the metabolic profile of these cell lines. The MTT assay was used for cytotoxicity determination. Apoptosis and expression of GSLs were assessed by flow cytometry. A GC-MS-coupled system was used for the separation and identification of metabolites. Compound 1 was cytotoxic for both cell lines, and the majority of cells died by treatment-induced apoptosis. The percentage of CSCs was significantly lower in the MDA-MB-231 cell line. Treatment with 1 caused a decrease of CSC IV6Neu5Ac-nLc4Cer+ MDA-MB-231 cells. In the MCF-7 cell line, the percentage of GalNAc-GM1b+ CSCs was increased, while the expression of Gg3Cer was decreased in both CSC and non-CSC. Twenty-one metabolites were identified by metabolic profiling. The major impact of the treatment was in glycolysis/gluconeogenesis, pyruvate and inositol metabolism. Compound 1 exhibited higher potency in MBA-MB-231 cells, and it deserves further examination

Between the Vinča and Linearbandkeramik worlds: the diversity of practices and identities in the 54th–53rd centuries cal BC in south-west Hungary and beyond

Szederk&eacute;ny-Kukorica-dűlő is a large settlement in south-east Transdanubia, Hungary, excavated in advance of road construction, which is notable for its combination of pottery styles, variously including Vinča A, Raži&scaron;te and LBK, and longhouses of a kind otherwise familiar from the LBK world. Formal modelling of its date establishes that the site probably began in the later 54th century cal BC, lasting until the first decades of the 52nd century cal BC. Occupation, featuring longhouses, pits and graves, probably began at the same time on the east and west parts of the settlement, the central part starting a decade or two later; the western part was probably abandoned last. Vinča pottery is predominantly associated with the east and central parts of the site, and Raži&scaron;te pottery with the west. Formal modelling of the early history and diaspora of longhouses in the LBK world suggests their emergence in the Formative LBK of Transdanubia c. 5500 cal BC and then rapid diaspora in the middle of the 54th century cal BC, associated with the &lsquo;earliest&rsquo; (&auml;lteste) LBK. The adoption of longhouses at Szederk&eacute;ny thus appears to come a few generations after the start of the diaspora. Rather than explaining the mixture of things, practices and perhaps people at Szederk&eacute;ny by reference to problematic notions such as hybridity, we propose instead a more fluid and varied vocabulary including combination and amalgamation, relationships and performance in the flow of social life, and networks; this makes greater allowance for diversity and interleaving in a context of rapid change

State of the direct reduction and reduction smelting processes

For quite a long time efforts have been made to develop processes for producing iron i.e. steel without employing conventional procedures - from ore, coke, blast furnace, iron, electric arc furnace, converter to steel. The insufficient availability and the high price of the coking coals have forced many countries to research and adopt the non-coke-consuming reduction and metal manufacturing processes (non-coke metallurgy, direct reduction, direct processes). This paper represents a survey of the most relevant processes from this domain by the end of 2000, which display a constant increase in the modern process metallurgy

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound

Angela Mastelić,1 Vedrana Čike&scaron; Čulić,1 Nikolina Režić Mužinić,1 Milena Vuica-Ross,2 David Barker,3 Euphemia Y Leung,4,5 J&oacute;hannes Reynisson,3 Anita Markotić1 1Department of Medical Chemistry and Biochemistry, University of Split School of Medicine, Split, Croatia; 2Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA; 3School of Chemical Sciences, The University of Auckland, 4Auckland Cancer Society Research Centre, The University of Auckland, 5Molecular Medicine and Pathology Department, The University of Auckland, Auckland, New Zealand Abstract: Tumor progression may be driven by a small subpopulation of cancer stem cells (CSCs characterized by CD44+/CD24- phenotype). We investigated the influence of a newly developed thienopyridine anticancer compound (3-amino-5-oxo-N-naphthyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide, 1) on the growth, survival and glycophenotype (CD15s and GM3 containing neuraminic acid substituted with acetyl residue, NeuAc) of breast and prostate cancer stem/progenitor-like cell population. MDA-MB-231 and Du-145 cells were incubated with compound 1 alone or in combination with paclitaxel. The cellular metabolic activity was determined by the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay. The type of cell death induced by 48-h treatment was assessed using a combination of Annexin-V-FITC and propidium iodide staining. Flow cytometric analysis was performed to detect the percentage of CD44+/CD24- cells, and GM3 and CD15s positive CSCs, as well as the expression of GM3 and CD15s per one CSC, in both cell lines. Compound 1 produces a dose- and time-dependent cytotoxicity, mediated mainly by apoptosis in breast cancer cells, and slightly (2.3%) but statistically significant lowering breast CSC subpopulation. GM3 expression per one breast CSC was increased, and the percentage of prostate GM3+ CSC subpopulation was decreased in cells treated with compound 1 compared with non-treated cells. The percentage of CD15s+ CSCs was lower in both cell lines after treatment with compound 1. Considering that triple-negative breast cancers are characterized by an increased percentage of breast CSCs and knowing their association with an increased risk of metastasis and mortality, compound 1 is a potentially effective drug for triple-negative breast cancer treatment. Keywords: breast, prostate, cancer stem cells, CD44+/CD24-, GM3, CD15