Coronary artery aneurysm in Kawasaki disease.

A 3-year-old male presents to the emergency department with chief complaints of fever and vomiting. He had a positive rapid streptococcus throat test with cervical lymphadenopathy. The patient was started on antibiotics. On examination, there was diffuse erythematous macular rash on the chest. Laboratory tests revealed elevated white cell count and C-reactive protein. Electrocardiogram was notable for prolonged PR interval indicating 1st degree atrioventricular block. Echocardiogram revealed ectasia of the right coronary artery (RCA). A presumptive diagnosis of Kawasaki disease was made and the patient was started on high-dose aspirin and intravenous immunoglobulins. Cardiac computed tomography angiography (CTA) showed an aneurysm of the proximal RCA measuring up to 7.4 mm. The RCA immediately proximal to the aneurysm measured 3 mm in diameter. The Z score was 13.4. Oblique coronal image from cardiac CTA and volume rendered images demonstrated an aneurysm of the proximal RCA. The patient improved with treatment

A STUDY ON THE PREVALENCE AND SEVERITY OF POSSIBLE DRUG-DRUG INTERACTIONS IN PEDIATRICS DEPARTMENT AT AN INDIAN TERTIARY CARE TEACHING HOSPITAL

Objective: To study the prevalence and severity of possible drug-drug interactions in the department of pediatrics.Methods: Case records of the in-patients of the pediatrics department from the medical records department were included and the records of the ambulatory patients were excluded from the study. All the collected cases were subjected to check for the drug-drug interactions by using the software micromedex 2.0 and the interactions were categorized based on the severity into minor, moderate and major.Results: A total of 142 cases were screened for possible drug-drug interactions (DDIs) and among them 76 cases were observed to be with possible DDIs.  The prevalence was found to be 53.5% in this study. Majority of the cases with possible DDIs were observed to be in females. Results of the age wise categorization revealed that majority of the possible DDIS were observed in children (2-12 y) followed by the infants (1 mo–2 y). The drug combinations amikacin+ampicillin, paracetamol+phenytoin and ofloxacin+ondansetron were found to be the frequently observed possible DDIs of minor, moderate and major severities respectively.Conclusion: Majority of the possible DDIs were of moderate severity followed by major. Clinical pharmacists should take the responsibility in assisting the pediatricians for screening the possible DDIs in the prescriptions there by preventing them and providing a better pharmaceutical care for the pediatric population. Â

A study on the prevalence of obesity and metabolic syndrome among students of a medical college

Background: Obesity is emerging as a serious problem throughout the world. The overall life expectancy is significantly shortened and the quality of life decreased in those who are excessively overweight. Metabolic syndrome (MetS) is characterized by a constellation of individual risk factors of cardiovascular disease. Central obesity is a key feature of this syndrome, reflecting the fact that the syndrome’s prevalence is driven by strong relationship between waist circumference and increasing obesity. Awareness about MetS in medical students is the need of the hour.Methods: This cross-sectional study was conducted at Dr. PSIMS and RF, Chinnoutpalli, Andhra Pradesh, India involving 400 medical students. A pre-tested questionnaire, measurement of blood pressure, fasting glucose level, fasting lipid profile, anthropometric variables such as height, weight, waist circumference and hip circumference were taken. Metabolic syndrome was defined based on the International Diabetes Federation criteria. Data was processed using SPSS version 16. T-test, chi-square test, fisher’s exact test, anova and odd’s ratio were used for statistical analysis.Results: 59% of the study population was female. The prevalence of obesity was 4%, with majority being males (81.25%) The MetS prevalence as per the International diabetes federation (IDF) criteria was 6% (n=24). The prevalence of MetS in males was 12.19% (n=20) and in females 1.69%. (n=4). The risk of developing metabolic syndrome is high among those who smoke, consume alcohol, consume junk food and sleep for longer durations.Conclusions: The prevalence of metabolic syndrome is 6%. A significant association is established between life style habits like smoking, alcohol consumption, junk food consumption, sleep duration and MetS

Sulfotransferase 1A1 (SULT1A1) Polymorphism and Breast Cancer Risk: A Case-control Study in South India

Introduction: Breast cancer is the most common cancer among women worldwide. Sulfotransferase plays an important role in the formation of estrogen which is usually conferred as a risk factor for breast cancer. The SULT1A1*2 polymorphism is likely to play an important role in the susceptibility to breast cancer. This polymorphism (G638A) in the sulfotransferase 1A1 (SULT1A1) gene may causes Arg213His amino acid change and consequently results in significantly reduced enzyme activity and thermostability.Materials and Methods: In this case-control study, we investigated the role of SULT1A1 G638A polymorphism in breast cancer patients. We genotyped 144 patients with breast cancer and 116 healthy control subjects, using a Polymerase chain reaction –Restriction Fragment length polymorphism (PCR-RFLP) method.Results: The frequencies of SULT1A1 G638G, G638A and A638A were 83.5%, 17.8%, and 1.4% in the breast cancer group and 89.5%, 4.0% and 0.0% in the control group. The results of our study indicate that the SULT1A1 G638A genotype showed 4.6 folds increased risk of breast cancer (p = 0.002).Conclusion: In conclusion, our results suggest that, SULT1A1 G638A variant is significantly associated with risk of breast cancer in south Indian women

Implementation of Intelligent Smart Heart Health Monitoring System using IOT

There are a lot of severe diseases that are associated with humans, but one of them is cardiac arrest, which, in general terms, we call a heart attack. The already existing heart rate monitoring systems are not mobile, are expensive, and take a little longer to give out the results. So, in this work, we will go for a system called Heart Rate Monitoring system using an ECG sensor and a Raspberry Pi, which actually represents the acquisition and interpretation of a human heart’s data collected with the help of sensors, anywhere and everywhere on the earth, through IOT. We generally consider heart rate while noting the status of the heart, but the oxygen level and body temperature also play a major role in determining the exact heart status. So, the hardware required to implement this heart rate monitoring model consists of different health sensors and a Raspberry Pi configured in a way to communicate with the guardian and the respective doctors over the Internet through an available smart mobile phone. In this work, the sensors configured with the hardware collect the required information about the patient’s health, which includes parameters such as the patient’s heart rate, body temperature, and SPo2 levels. Then, using the collected information from the sensors, the patient’s heart activity is actively observed. Thus, the patient himself or herself can easily identify his or her heart condition with the help of collected data anywhere on the earth through the internet. An alert indicating that their heart status is not good is displayed to the caretakers on the mobile, which shows a message called "abnormal condition to the patient" given the condition that the collected sensors’ values are beyond the threshold information through the GSM module, and also the GPS location of the patient will be sent to the caretakers as well as to the doctors

Immigrant status and cardiovascular risk over time: results from the Multi-Ethnic Study of Atherosclerosis

Despite cross-sectional evidence that foreign-born United States (US) residents often have better health than US-born residents of similar race/ethnicity, we know little about overall cardiovascular risk progression over time among immigrants as they age in the US

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy

published_or_final_versio

Immigrant assimilation and BMI and waist size: A longitudinal examination among hispanic and chinese participants in the multi‐ethnic study of atherosclerosis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99611/1/oby20104.pd