6 research outputs found
Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid
The L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid (DF) was synthesized and its crystal structure characterized by the X-ray diffraction method. The crystal system is orthorhombic with space group P2(1)2(1)2(1) and cell constants a = 8.2969(3) angstrom, b = 18.9358(8) angstrom, c = 20.0904(6) angstrom, V = 3156.4(2) angstrom(3) and Z = 4. Ring A of the steroid nucleus and phenyl ring in the 17 beta-side chain are almost planar. Rings B and C have a slightly distorted chair conformation, whereas ring D has an envelope conformation. The packing of DF is characterized by a network of intermolecular hydrogen bonds involving the O4 atom from one side of the steroid nucleus and O1 and F1 atoms from the other side as hydrogen bond acceptors. Apart from the intermolecular hydrogen bonds in the crystal packing, there are also numerous intramolecular hydrogen bonds of the N-H center dot center dot center dot O, C-H center dot center dot center dot O and C-H center dot center dot center dot F type. The local anti-inflammatory activity of DF was evaluated using the croton oil-induced ear oedema test. This derivative achieved maximal inhibition of ear oedema at significantly lower concentration in comparison with dexamethasone
Serum liver enzyme levels in Wistar rats 28 days orally exposed to the mixture of BDE209 and cadmium
Synthesis, crystal structure and local anti-inflammatory activity of the L-phenylalanine methyl ester derivative of dexamethasone-derived cortienic acid
L-phenylalanine methyl ester derivative of dexamethasone - derived cortienic
acid (DF) was synthesized and its crystal structure was characterized by
X-ray diffraction method. The crystal system is orthorhombic with space
group P212121 and cell constants a = 8.2969 (3) Å, b = 18.9358 (8) Å, c =
20.0904 (6) Å, V = 3156.4 (2) Å3 and Z = 4. Ring A of the steroid nucleus
and phenyl ring in the 17β-side chain are almost planar. Rings B and C have
a slightly distorted chair conformation, whereas ring D has an envelope
conformation. The packing of DF is characterized by a network of
intermolecular hydrogen bonds involving the O4 atom from one side of the
steroid nucleus and O1 and F1 atoms from the other side as hydrogen bond
acceptors. Apart from the intermolecular hydrogen bonds in the crystal
packing, there are also numerous intramolecular hydrogen bonds of the
N-H...O, C-H...O and C-H...F type. Local anti-inflammatory activity of DF
was evaluated by use of croton oil-induced ear edema test. This derivative
achieved maximal inhibition of ear edema at significantly lower
concentration in comparison with dexamethasone. [Projekat Ministarstva nauke
Republike Srbije, br. 172041, 172014 i 172035