Therapy chronic trichomoniasis at patients with associated urogenital chlamydial infection

Present material of problem question therapy chronic trichomoniasis. Study clinical and bacteriological effectiveness basic etiotropic preparation and their combination, used in treatment patients trichomoniasis. Found that the combined application antiprotozoal drugs have a more pronounced effect on kills T. vaginalis and shortens the rehabilitation of the patient

The effectiveness of a monopreparation containing a combination of ciprofloxacin – ornidazole in the treatment of infectious-inflammatory and dysbiotic vagina diseases

Introduction. Infectious inflammatory and dysbiotic diseases of the vagina represent a major concern facing obstetric and gynecological science. Individually, the two most common specific diseases can be distinguished, namely: bacterial vaginosis (BV) and nonspecific vaginitis (NV). The therapeutic strategy for these diseases requires a word of clarification and adjustment.Objective. To conduct a comparative analysis of treatment with the combination drug Orcepol WM (ciprofloxacin (500 mg) and ornidazole (500 mg)) and a combination of monopreparations in a dosage form similar to Orcepol WM.Materials and methods. As a comparison object, we used the method of simultaneous administration by patients of tablet forms of ciprofloxacin and ornidazole as mono-preparations in a dosage of 500 mg similar to Orcepol. The study included 64 patients with diagnoses of “bacterial vaginosis” or “nonspecific vaginitis” or "decompensated mixed vaginal dysbiosis". The average age of the patients was 35.34 ± 5.95 years. The patients were divided into two groups: group 1 (n = 32) received the combination drug Orcepol WM, group 2 (n = 32) received ciprofloxacin and ornidazole with two mono-preparations. The drugs were prescribed as a five-day course, two times a day. The patients were followed up by a doctor during two visits and one remote interview on day 30–45 after the end of treatment (visit 2).Results. In both groups, all patients received a full course of antibacterial therapy. There were no adverse drug reactions. In both groups, there was an improvement in clinical symptoms from the first to the second visit: discomfort, itching, burning, dyspareunia, hyperemia of the mucous membrane against the background of normalization of laboratory findings of the vaginal microbiocenosis condition. At the same time, the best results were higher in group 1. Manifestation of mycotic vaginitis with the development of strong clinical symptomatology on days 3 and 4 of treatment respectively were recorded in 4 (12.5%) patients from group 1 and 7 (21.9%) from group 2. The results of comparative observation showed that the number of relapses after the end of therapy were the same in group 1 (8 out of 32 patients, 25%) and in group 2 (9 out of 32 patients, 28%). The relapse occurred on average day 12 and 17 after the end of therapy, respectively.Сonclusion. Thus, the use of Orcepol WM showed a greater therapeutic efficacy as compared to the use of tablet forms of ciprofloxacin and ornidazole in similar dosages as a single-drug administration, which can be explained by a stronger patients' adherence to the treatment

Band-gap and sub-band-gap photoelectrochemical processes at nanocrystalline CdS grown on ZnO by successive ionic layer adsorption and reaction method

Cadmium sulfide nanoparticle (NP) deposition by the successive ionic layer adsorption and reaction (SILAR) method on the surface of mesoporous ZnO micro-platelets with a large specific surface area (110 ± 10 m2g− 1) results in the formation of ZnO/CdS heterostructures exhibiting a high incident photon-to-current conversion efficiency (Y) not only within the region of CdS fundamental absorption (Ymax = 90%; 0.1 M Na2S + 0.1 M Na2SO3), but also in the sub-band-gap (SBG) range (Ymax = 25%). The onset potentials of SBG photoelectrochemical processes are more positive than the band-gap (BG) onset potential by up to 100 mV. A maximum incident photon-to-current conversion efficiency value for SBG processes is observed at larger amount of deposited CdS in comparison with the case of BG ones. The Urbach energy (EU) of CdS NPs determined from the photocurrent spectra reaches a maximal value on an early deposition stage (EU = 93 mV at SILAR cycle number N = 5), then lowers somewhat (EU = 73 mV at N = 10) and remains steady in the range of N from 20 to 300 (EU = 67 ± 1 mV). High efficiency of the photoelectrochemical SBG processes are interpreted in terms of light scattering in the ZnO/CdS heterostructures

Функцыяналізацыя паверхні слюды і алюмінію азіднымі групамі

Aluminium and mica (muscovite) plates have been functionalized with azide groups by a protocol which includes (3-chloropropyl) trichlorosilane modification followed by chlorine atom nucleophilic substitution by azide. The azide groups have been transformed to dimethoxytrityl (DMT) ones by [3+2] azide-alkyne cycloaddition reaction. This made it possible to determine their number per surface unit photometrically, based on the absorption of the DMT cation. The functionalization method allowed to achieve high surface load of the materials by azide groups, which was 2.2 and 2.7 nm-2 for mica and aluminium, respectively. The mica plates have been additionally functionalized by 25 kDa branched polyethylenimine. The samples have shown a capability for adsorptive nanoand microobjects immobilization. The feature could be useful for atomic force microscopy, which have been demonstrated with erythrocytes and exosomes.Праведзена функцыяналізацыя паверхні пласцін алюмінію і слюды (мускавіт) азіднымі групамі з выкарыстаннем методыкі, якая ўключае мадыфікацыю (3-хлорпрапіл)трыхлорсіланам і наступнае нуклеафільнае замяшчэнне атама хлору азідным аніёнам. Трансфармацыя азідных груп у дыметоксітрытыльныя (ДМТ) па рэакцыі [3+2] азід-алкінавага цыкладалучэння дазволіла фотаметрычна, па паглынанню ДМТ-катыёну, вызначыць іх колькасць на адзінку паверхні. Методыка функцыяналізацыі дазволіла дасягнуць высокай загрузкі матэрыялаў азіднымі групамі, якая склала 2,2 і 2,7 нм–2 для слюды і алюмінію адпаведна. Паверхню слюды дадаткова мадыфікавалі разгалінаваным поліэтыленімінам з масай 25 кДа. Узоры слюды паказалі здольнасць да адсарбцыйнай імабілізацыі нанаі мікрааб’ектаў. Такая ўласцівасць можа быць карыснай для выкарыстання іх у якасці падложак для атамнасілавой мікраскапіі, што было паказана на прыкладзе эрытрацытаў і экзасом

Polycrystalline bismuth films: correlation between grain structure and electron transport

Grain structure and the temperature dependences of resistivity, magnetoresistance, Hall and Seebeck coefficients measured in the range from 4 to 300 K were investigated for polycrystalline bismuth films obtained by the melt spinning (MS) and electrochemical deposition (ECD) methods. Charge-carrier concentration and mobilities were calculated assuming the carrier scattering on acoustic deformation potential as the dominant scattering mechanism, parabolicity of holes dispersion law, implying the Lax model for L-band electrons and neglecting the influence of L-band holes on conductivity. The experimental results and calculations have demonstrated that the electrical properties of the Bi films studied are strongly affected by the grain-boundary density

Theory of differential inclusions and its application in mechanics

The following chapter deals with systems of differential equations with discontinuous right-hand sides. The key question is how to define the solutions of such systems. The most adequate approach is to treat discontinuous systems as systems with multivalued right-hand sides (differential inclusions). In this work three well-known definitions of solution of discontinuous system are considered. We will demonstrate the difference between these definitions and their application to different mechanical problems. Mathematical models of drilling systems with discontinuous friction torque characteristics are considered. Here, opposite to classical Coulomb symmetric friction law, the friction torque characteristic is asymmetrical. Problem of sudden load change is studied. Analytical methods of investigation of systems with such asymmetrical friction based on the use of Lyapunov functions are demonstrated. The Watt governor and Chua system are considered to show different aspects of computer modeling of discontinuous systems