339 research outputs found
Impact of an interdisciplinary strategy on antibiotic use: a prospective controlled study in three hospitals
Objectives: Evaluation of the impact of the implementation of practice guidelines, with or without their reinforcement by a pharmacist, on the intra-hospital use of antibiotics. Materials and methods: The duration of antibiotic treatment, their cost, and the length of patient stay were compared in three secondary-care hospitals, before and after interventions that were designed to promote rational antibiotic use. After randomization, hospital A received no intervention (control), local practice guidelines were implemented in hospital B (low grade intervention), and these guidelines were reinforced by a clinical pharmacist in hospital C (high grade intervention). Adherence to the guidelines was measured in hospitals B and C. Multivariable statistical analyses were carried out to adjust for confounding factors. Results: None of the outcomes measured in the 1200 included patients decreased between the two study periods in any hospital. Hospital A was significantly and independently associated with an increase in the duration of antibiotic treatments, the cost of antibiotics (acquisition and global costs), and the length of stay. Although these differences were not statistically significant, increases in hospital B were higher than in hospital C. Adherence to guidelines was significantly higher in hospital C. Conclusions: Even though interdisciplinary interventions aiming at rationalizing antibiotic use could not diminish the duration of treatments, their costs or the length of stay, they proved useful to control the progression of these parameter
Impact of an interdisciplinary strategy on antibiotic use: a prospective controlled study in three hospitals.
OBJECTIVES: Evaluation of the impact of the implementation of practice guidelines, with or without their reinforcement by a pharmacist, on the intra-hospital use of antibiotics. MATERIALS AND METHODS: The duration of antibiotic treatment, their cost, and the length of patient stay were compared in three secondary-care hospitals, before and after interventions that were designed to promote rational antibiotic use. After randomization, hospital A received no intervention (control), local practice guidelines were implemented in hospital B (low grade intervention), and these guidelines were reinforced by a clinical pharmacist in hospital C (high grade intervention). Adherence to the guidelines was measured in hospitals B and C. Multivariable statistical analyses were carried out to adjust for confounding factors. RESULTS: None of the outcomes measured in the 1200 included patients decreased between the two study periods in any hospital. Hospital A was significantly and independently associated with an increase in the duration of antibiotic treatments, the cost of antibiotics (acquisition and global costs), and the length of stay. Although these differences were not statistically significant, increases in hospital B were higher than in hospital C. Adherence to guidelines was significantly higher in hospital C. CONCLUSIONS: Even though interdisciplinary interventions aiming at rationalizing antibiotic use could not diminish the duration of treatments, their costs or the length of stay, they proved useful to control the progression of these parameters
Clinical Use and Therapeutic Potential of IVIG/SCIG, Plasma-Derived IgA or IgM, and Other Alternative Immunoglobulin Preparations
Intravenous and subcutaneous immunoglobulin preparations, consisting of IgG class antibodies, are increasingly used to treat a broad range of pathological conditions, including humoral immune deficiencies, as well as acute and chronic inflammatory or autoimmune disorders. A plethora of Fab- or Fc-mediated immune regulatory mechanisms has been described that might act separately or in concert, depending on pathogenesis or stage of clinical condition. Attempts have been undertaken to improve the efficacy of polyclonal IgG preparations, including the identification of relevant subfractions, mild chemical modification of molecules, or modification of carbohydrate side chains. Furthermore, plasma-derived IgA or IgM preparations may exhibit characteristics that might be exploited therapeutically. The need for improved treatment strategies without increase in plasma demand is a goal and might be achieved by more optimal use of plasma-derived proteins, including the IgA and the IgM fractions. This article provides an overview on the current knowledge and future strategies to improve the efficacy of regular IgG preparations and discusses the potential of human plasma-derived IgA, IgM, and preparations composed of mixtures of IgG, IgA, and IgM
A novel camera type for very high energy gamma-ray astronomy based on Geiger-mode avalanche photodiodes
Geiger-mode avalanche photodiodes (G-APD) are promising new sensors for light
detection in atmospheric Cherenkov telescopes. In this paper, the design and
commissioning of a 36-pixel G-APD prototype camera is presented. The data
acquisition is based on the Domino Ring Sampling (DRS2) chip. A sub-nanosecond
time resolution has been achieved. Cosmic-ray induced air showers have been
recorded using an imaging mirror setup, in a self-triggered mode. This is the
first time that such measurements have been carried out with a complete G-APD
camera.Comment: 9 pages with 11 figure
Calibration and performance of the photon sensor response of FACT -- The First G-APD Cherenkov telescope
The First G-APD Cherenkov Telescope (FACT) is the first in-operation test of
the performance of silicon photo detectors in Cherenkov Astronomy. For more
than two years it is operated on La Palma, Canary Islands (Spain), for the
purpose of long-term monitoring of astrophysical sources. For this, the
performance of the photo detectors is crucial and therefore has been studied in
great detail. Special care has been taken for their temperature and voltage
dependence implementing a correction method to keep their properties stable.
Several measurements have been carried out to monitor the performance. The
measurements and their results are shown, demonstrating the stability of the
gain below the percent level. The resulting stability of the whole system is
discussed, nicely demonstrating that silicon photo detectors are perfectly
suited for the usage in Cherenkov telescopes, especially for long-term
monitoring purpose
FACT -- Operation of the First G-APD Cherenkov Telescope
Since more than two years, the First G-APD Cherenkov Telescope (FACT) is
operating successfully at the Canary Island of La Palma. Apart from its purpose
to serve as a monitoring facility for the brightest TeV blazars, it was built
as a major step to establish solid state photon counters as detectors in
Cherenkov astronomy.
The camera of the First G-APD Cherenkov Telesope comprises 1440 Geiger-mode
avalanche photo diodes (G-APD aka. MPPC or SiPM) for photon detection. Since
properties as the gain of G-APDs depend on temperature and the applied voltage,
a real-time feedback system has been developed and implemented. To correct for
the change introduced by temperature, several sensors have been placed close to
the photon detectors. Their read out is used to calculate a corresponding
voltage offset. In addition to temperature changes, changing current introduces
a voltage drop in the supporting resistor network. To correct changes in the
voltage drop introduced by varying photon flux from the night-sky background,
the current is measured and the voltage drop calculated. To check the stability
of the G-APD properties, dark count spectra with high statistics have been
taken under different environmental conditions and been evaluated.
The maximum data rate delivered by the camera is about 240 MB/s. The recorded
data, which can exceed 1 TB in a moonless night, is compressed in real-time
with a proprietary loss-less algorithm. The performance is better than gzip by
almost a factor of two in compression ratio and speed. In total, two to three
CPU cores are needed for data taking. In parallel, a quick-look analysis of the
recently recorded data is executed on a second machine. Its result is publicly
available within a few minutes after the data were taken.
[...]Comment: 19th IEEE Real-Time Conference, Nara, Japan (2014
FACT -- the First Cherenkov Telescope using a G-APD Camera for TeV Gamma-ray Astronomy (HEAD 2010)
Geiger-mode Avalanche Photodiodes (G-APD) bear the potential to significantly
improve the sensitivity of Imaging Air Cherenkov Telescopes (IACT). We are
currently building the First G-APD Cherenkov Telescope (FACT) by refurbishing
an old IACT with a mirror area of 9.5 square meters and construct a new, fine
pixelized camera using novel G-APDs. The main goal is to evaluate the
performance of a complete system by observing very high energy gamma-rays from
the Crab Nebula. This is an important field test to check the feasibility of
G-APD-based cameras to replace at some time the PMT-based cameras of planned
future IACTs like AGIS and CTA. In this article, we present the basic design of
such a camera as well as some important details to be taken into account.Comment: Poster shown at HEAD 2010, Big Island, Hawaii, March 1-4, 201
Development of surrogate correlation models to predict trace organic contaminant oxidation and microbial inactivation during ozonation
The performance of ozonation in wastewater depends on water quality and the ability to form hydroxyl radicals ( OH) to meet disinfection or contaminant transformation objectives. Since there are no on-line methods to assess ozone and OH exposure in wastewater, many agencies are now embracing indicator frameworks and surrogate monitoring for regulatory compliance. Two of the most promising surrogate parameters for ozone-based treatment of secondary and tertiary wastewater effluents are differential UV254 absorbance (ÎUV254) and total fluorescence (ÎTF). In the current study, empirical correlations for ÎUV254 and ÎTF were developed for the oxidation of 18 trace organic contaminants (TOrCs), including 1,4-dioxane, atenolol, atrazine, bisphenol A, carbamazepine, diclofenac, gemfibrozil, ibuprofen, meprobamate, naproxen, N,N-diethyl-meta-toluamide (DEET), para-chlorobenzoic acid (pCBA), phenytoin, primidone, sulfamethoxazole, triclosan, trimethoprim, and tris-(2-chloroethyl)-phosphate (TCEP) (R2 = 0.50â0.83) and the inactivation of three microbial surrogates, including Escherichia coli, MS2, and Bacillus subtilis spores (R2 = 0.46â0.78). Nine wastewaters were tested in laboratory systems, and eight wastewaters were evaluated at pilot- and full-scale. A predictive model for OH exposure based on ÎUV254 or ÎTF was also proposed
FACT -- The G-APD revolution in Cherenkov astronomy
Since two years, the FACT telescope is operating on the Canary Island of La
Palma. Apart from its purpose to serve as a monitoring facility for the
brightest TeV blazars, it was built as a major step to establish solid state
photon counters as detectors in Cherenkov astronomy. The camera of the First
G-APD Cherenkov Telesope comprises 1440 Geiger-mode avalanche photo diodes
(G-APD), equipped with solid light guides to increase the effective light
collection area of each sensor. Since no sense-line is available, a special
challenge is to keep the applied voltage stable although the current drawn by
the G-APD depends on the flux of night-sky background photons significantly
varying with ambient light conditions. Methods have been developed to keep the
temperature and voltage dependent response of the G-APDs stable during
operation. As a cross-check, dark count spectra with high statistics have been
taken under different environmental conditions. In this presentation, the
project, the developed methods and the experience from two years of operation
of the first G-APD based camera in Cherenkov astronomy under changing
environmental conditions will be presented.Comment: Proceedings of the Nuclear Science Symposium and Medical Imaging
Conference (IEEE-NSS/MIC), 201
FACT - The First G-APD Cherenkov Telescope: Status and Results
The First G-APD Cherenkov telescope (FACT) is the first telescope using
silicon photon detectors (G-APD aka. SiPM). It is built on the mount of the
HEGRA CT3 telescope, still located at the Observatorio del Roque de los
Muchachos, and it is successfully in operation since Oct. 2011. The use of
Silicon devices promises a higher photon detection efficiency, more robustness
and higher precision than photo-multiplier tubes. The FACT collaboration is
investigating with which precision these devices can be operated on the
long-term. Currently, the telescope is successfully operated from remote and
robotic operation is under development. During the past months of operation,
the foreseen monitoring program of the brightest known TeV blazars has been
carried out, and first physics results have been obtained including a strong
flare of Mrk501. An instantaneous flare alert system is already in a testing
phase. This presentation will give an overview of the project and summarize its
goals, status and first results
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