435 research outputs found
First year engineering mathematics: the London South Bank University experience
This short article describes an innovative approach to teaching mathematics to first year undergraduates on
a variety of B. Eng. courses offered in the Faculty of Engineering, Science and Built Environment (FESBE) of
London South Bank University (LSBU)
Forest resampling for distributed sequential Monte Carlo
This paper brings explicit considerations of distributed computing
architectures and data structures into the rigorous design of Sequential Monte
Carlo (SMC) methods. A theoretical result established recently by the authors
shows that adapting interaction between particles to suitably control the
Effective Sample Size (ESS) is sufficient to guarantee stability of SMC
algorithms. Our objective is to leverage this result and devise algorithms
which are thus guaranteed to work well in a distributed setting. We make three
main contributions to achieve this. Firstly, we study mathematical properties
of the ESS as a function of matrices and graphs that parameterize the
interaction amongst particles. Secondly, we show how these graphs can be
induced by tree data structures which model the logical network topology of an
abstract distributed computing environment. Thirdly, we present efficient
distributed algorithms that achieve the desired ESS control, perform resampling
and operate on forests associated with these trees
Electron-fluctuation interaction in a non-Fermi superconductor
We studied the influence of the amplitude fluctuations of a non-Fermi
superconductor on the energy spectrum of the 2D Anderson non-Fermi system. The
classical fluctuations give a temperature dependence in the pseudogap induced
in the fermionic excitations.Comment: revtex fil
Bioprospecting Fluorescent Plant Growth Regulators from Arabidopsis to Vegetable Crops
The phytohormone auxin is involved in almost every process of a plant’s life, from germination to plant development. Nowadays, auxin research connects synthetic chemistry, plant biology and computational chemistry in order to develop innovative and safe compounds to be used in sustainable agricultural practice. In this framework, we developed new fluorescent compounds, ethanolammonium p-aminobenzoate (HEA-pABA) and p-nitrobenzoate (HEA-pNBA), and investigated their auxin-like behavior on two main commercial vegetables cultivated in Europe, cucumber (Cucumis sativus) and tomato (Solanumlycopersicum), in comparison to the model plant Arabidopsis (Arabidopsis thaliana). Moreover, the binding modes and affinities of two organic salts in relation to the natural auxin indole-3-acetic acid (IAA) into TIR1 auxin receptor were investigated by computational approaches (homology modeling and molecular docking). Both experimental and theoretical results highlight HEA-pABA as a fluorescent compound with auxin-like activity both in Arabidopsis and the commercial cucumber and tomato. Therefore, alkanolammonium benzoates have a great potential as promising sustainable plant growth stimulators to be efficiently used in vegetable crops
Thermodynamics of a trapped interacting Bose gas and the renormalization group
We apply perturbative renormalization group theory to the symmetric phase of
a dilute interacting Bose gas which is trapped in a three-dimensional harmonic
potential. Using Wilsonian energy-shell renormalization and the
epsilon-expansion, we derive the flow equations for the system. We relate these
equations to the flow for the homogeneous Bose gas. In the thermodynamic limit,
we apply our results to study the transition temperature as a function of the
scattering length. Our results compare well to previous studies of the problem.Comment: 14 pages, 5 figure
Physics at a Neutrino Factory
In response to the growing interest in building a Neutrino Factory to produce
high intensity beams of electron- and muon-neutrinos and antineutrinos, in
October 1999 the Fermilab Directorate initiated two six-month studies. The
first study, organized by N. Holtkamp and D. Finley, was to investigate the
technical feasibility of an intense neutrino source based on a muon storage
ring. This design study has produced a report in which the basic conclusion is
that a Neutrino Factory is technically feasible, although it requires an
aggressive R&D program. The second study, which is the subject of this report,
was to explore the physics potential of a Neutrino Factory as a function of the
muon beam energy and intensity, and for oscillation physics, the potential as a
function of baseline.Comment: 133 pages, 64 figures. Report to the Fermilab Directorate. Available
from http://www.fnal.gov/projects/muon_collider/ This version fixes some
printing problem
Information geometric nonlinear filtering
This paper develops information geometric representations for nonlinear filters in continuous time. The posterior distribution associated with an abstract nonlinear filtering problem is shown to satisfy a stochastic differential equation on a Hilbert information manifold. This supports the Fisher metric as a pseudo-Riemannian metric. Flows of Shannon information are shown to be connected with the quadratic variation of the process of posterior distributions in this metric. Apart from providing a suitable setting in which to study such information-theoretic properties, the Hilbert manifold has an appropriate topology from the point of view of multi-objective filter approximations. A general class of finite-dimensional exponential filters is shown to fit within this framework, and an intrinsic evolution equation, involving Amari's -1-covariant derivative, is developed for such filters. Three example systems, one of infinite dimension, are developed in detail
Isolation and characterization of equine native MSC populations
Abstract Background In contrast to humans in which mesenchymal stem/stromal cell (MSC) therapies are still largely in the clinical trial phase, MSCs have been used therapeutically in horses for over 15 years, thus constituting a valuable preclinical model for humans. In human tissues, MSCs have been shown to originate from perivascular cells, namely pericytes and adventitial cells, which are identified by the presence of the cell surface markers CD146 and CD34, respectively. In contrast, the origin of MSCs in equine tissues has not been established, preventing the isolation and culture of defined cell populations in that species. Moreover, a comparison between perivascular CD146+ and CD34+ cell populations has not been performed in any species. Methods Immunohistochemistry was used to identify adventitial cells (CD34+) and pericytes (CD146+) and to determine their localization in relation to MSCs in equine tissues. Isolation of CD34+ (CD34+/CD146–/CD144–/CD45–) and CD146+ (CD146+/CD34–/CD144–/CD45–) cell fractions from equine adipose tissue was achieved by fluorescence-activated cell sorting. The isolated cell fractions were cultured and analyzed for the expression of MSC markers, using qPCR and flow cytometry, and for the ability to undergo trilineage differentiation. Angiogenic properties were analyzed in vivo using a chorioallantoic membrane (CAM) assay. Results Both CD34+ and CD146+ cells displayed typical MSC features, namely growth in uncoated tissue culture dishes, clonal growth when seeded at low density, expression of typical MSC markers, and multipotency shown by the capacity for trilineage differentiation. Of note, CD146+ cells were distinctly angiogenic compared with CD34+ and non-sorted cells (conventional MSCs), demonstrated by the induction of blood vessels in a CAM assay, expression of elevated levels of VEGFA and ANGPT1, and association with vascular networks in cocultures with endothelial cells, indicating that CD146+ cells maintain a pericyte phenotype in culture. Conclusion This study reports for the first time the successful isolation and culture of CD146+ and CD34+ cell populations from equine tissues. Characterization of these cells evidenced their distinct properties and MSC-like phenotype, and identified CD146+ cells as distinctly angiogenic, which may provide a novel source for enhanced regenerative therapies
High-Tc Superconductivity and Antiferromagnetism in Multilayered Copper Oxides - A New Paradigm of Superconducting Mechanism -
High-temperature superconductivity (HTSC) in copper oxides emerges on a
layered CuO2 plane when an antiferromagnetic Mott insulator is doped with
mobile hole carriers. We review extensive studies of multilayered copper oxides
by site-selective nuclear magnetic resonance (NMR), which have uncovered the
intrinsic phase diagram of antiferromagnetism (AFM) and HTSC for a
disorder-free CuO2 plane with hole carriers. We present our experimental
findings such as the existence of the AFM metallic state in doped Mott
insulators, the uniformly mixed phase of AFM and HTSC, and the emergence of
d-wave SC with a maximum Tc just outside a critical carrier density, at which
the AFM moment on a CuO2 plane disappears. These results can be accounted for
by the Mott physics based on the t-J model. The superexchange interaction J_in
among spins plays a vital role as a glue for Cooper pairs or mobile
spin-singlet pairs, in contrast to the phonon-mediated attractive interaction
among electrons established in the Bardeen-Cooper-Schrieffer (BCS) theory. We
remark that the attractive interaction for raising the of HTSC up to
temperatures as high as 160 K is the large J_in (~0.12 eV), which binds
electrons of opposite spins to be on neighboring sites, and that there are no
bosonic glues. It is the Coulomb repulsive interaction U(> 6 eV) among Cu-3d
electrons that plays a central role in the physics behind high-Tc phenomena. A
new paradigm of the SC mechanism opens to strongly correlated electron matter.Comment: 20 pages, 25 figures, Special topics "Recent Developments in
Superconductivity" in J. Phys. Soc. Jpn., Published December 26, 201
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