GaAs(111)A and B in hydrazine sulfide solutions : extreme polarity dependence of surface adsorption processes

Chemical bonds formed by hydrazine-sulfide treatment of GaAs(111) were studied by synchrotron photoemission spectroscopy. At the B surface, the top arsenic atoms are replaced by nitrogen atoms, while GaAs(111)A is covered by sulfur, also bonded to underlying gallium, despite the sulfide molar concentration being 103 times smaller than that of the hydrazine. This extreme dependence on surface polarity is explained by competitive adsorption processes of HS- and OH- anions and of hydrazine molecules, on Ga- adsorption sites, which have distinct configurations on the A and B surfaces

Cs-induced charge transfer on (2x4)-GaAs(001) studied by photoemission

Cesium adsorption on 2x4 GaAs (001) was studied by photoemission and low energy electron diffraction. The different Cs induced changes of the As 3d and Ga 3d core level spectra show that charge transfer is almost complete for Ga surface sites, but is negligible to surface As at a coverage smaller than 0.3 ML. The situation is opposite for a coverage larger than 0.3ML, at which transfer occurs to As but no longer to Ga. Charge transfer to As atoms leads to disordering and destabilization and induces surface conversion from the As-rich surface to the Ga-rich 4x2 one after annealing at a reduced temperature of 450 C

Measuring the impact of spatial network layout on community social cohesion: A cross-sectional study

Background: There is now a substantial body of research suggesting that social cohesion, a collective characteristic measured by the levels of trust, reciprocity and formation of strong social bonds within communities, is an important factor in determining health. Of particular interest is the extent to which factors in the built environment facilitate, or impede, the development of social bonds. Severance is a characteristic of physical environments which is hypothesized to inhibit cohesion. In the current study we test a number of characteristics of spatial networks which could be hypothesized to relate either to severance, or directly to community cohesion. Particular focus is given to our most promising variable for further analysis (Convex Hull Maximum Radius 600 m).Methods: In the current study we analysed social cohesion as measured at Enumeration District level, aggregated from a survey of 10,892 individuals aged 18 to 74 years in the Caerphilly Health and Social Needs Cohort Study, 2001. In a data mining process we test 16 network variables on multiple scales. The variable showing the most promise is validated in a test on an independent data set. We then conduct a multivariate regression also including Townsend deprivation scores and urban/rural status as predictor variables for social cohesion.Results: We find convex hull maximum radius at a 600 m scale to have a small but highly significant correlation with social cohesion on both data sets. Deprivation has a stronger effect. Splitting the analysis by tertile of deprivation, we find that the effect of severance as measured by this variable is strongest in the most deprived areas. A range of spatial scales are tested, with the strongest effects being observed at scales that match typical walking distances.Conclusion: We conclude that physical connectivity as measured in this paper has a significant effect on social cohesion, and that our measure is unlikely to proxy either deprivation or the urban/rural status of communities. Possible mechanisms for the effect include intrinsic navigability of areas, and the existence of a focal route on which people can meet on foot. Further investigation may lead to much stronger predictive models of social cohesion. © 2014 Cooper et al.; licensee BioMed Central Ltd.Link_to_subscribed_fulltex

Intra-articular administration of lidocaine plus adrenaline in dogs : pharmacokinetic profile and evaluation of toxicity in vivo and in vitro

The aim of this study was to evaluate the safety of intra-articular (IA) lidocaine plus adrenaline for improving peri-operative analgesia in anaesthetised dogs undergoing arthroscopy of the elbow. A solution of lidocaine (L) 1.98% plus adrenaline 1:100.000 was administered via the IA route and its safety evaluated in terms of cardio- neuro- and chondro-toxicity. No bradycardia or hypotension was recorded from induction to the last observational time point. Signs of toxicity of the nervous system could have been masked by the general anaesthesia but lidocaine concentrations detected in the blood were lower than those thought to be capable of producing toxicity. The assessment of in vitro chondrotoxicity showed a dose- and time-dependent effect of lidocaine on the viability of articular cells. Adrenaline appeared to reduce the chondrotoxicity of 1% lidocaine, following an exposure of up to 30 min

Using multiple hybrid spatial design network analysis to predict longitudinal effect of a major city centre redevelopment on pedestrian flows

Predicting how changes to the urban environment layout will affect the spatial distribution of pedestrian flows is important for environmental, social and economic sustainability. We present longitudinal evaluation of a model of the effect of urban environmental layout change in a city centre (Cardiff 2007–2010), on pedestrian flows. Our model can be classed as regression based direct demand using Multiple Hybrid Spatial Design Network Analysis (MH-sDNA) assignment, which bridges the gap between direct demand models, facility-based activity estimation and spatial network analysis (which can also be conceived as a pedestrian route assignment based direct demand model). Multiple theoretical flows are computed based on retail floor area: everywhere to shops, shop to shop, railway stations to shops and parking to shops. Route assignment, in contrast to the usual approach of shortest path only, is based on a hybrid of shortest path and least directional change (most direct) with a degree of randomization. The calibration process determines a suitable balance of theoretical flows to best match observed pedestrian flows, using generalized cross-validation to prevent overfit. Validation shows that the model successfully predicts the effect of layout change on flows of up to approx. 8000 pedestrians per hour based on counts spanning a 1 km2 city centre, calibrated on 2007 data and validated to 2010 and 2011. This is the first time, to our knowledge, that a pedestrian flow model with assignment has been evaluated for its ability to forecast the effect of urban layout changes over time

Lead Speciation in the Dusts Emitted from Non-Ferrous Metallurgy Processes

The paper presents results for the speciation analysis of lead in dusts derived from dedusting of technological gasses from metallurgical processes of non-ferrous metals with different elementary content, made in accordance with two equal sequential extractions. Analytical procedure A provided possibilities for determination of fraction of Pb2+, metallic lead and fraction containing mainly lead sulfides. The second procedure (procedure B) was sequential extraction in accordance with Tessier. The results obtained in accordance with procedure A indicate that, regardless of the dust origin, the dominant group of Pb compounds is composed of lead salts which are soluble under alkaline conditions or lead compounds that form plumbites in the reaction with NaOH

Polyesters with main and side chain phosphoesters as structural motives for biocompatible electrospun fibres

Phosphoester containing polymers are promising materials in biomedical applications due to their biocompatibility and biodegradability. Utilising thiol-ene chemistry, the synthesis of two novel structural polymer motives combining polyesters and phophoester groups was explored. The first polymer was obtained by coupling ene-functional poly(thioether-phosphoester) with thiol functional poly(pentadecalactone). While the coupling reaction was successful, yields remained low presumably due to inadequate endgroup stoichiometry. The second polymer comprised phosphoester side groups conjugated to unsaturated poly(globalide). Double bond conversions up to 84% were achieved depending of the type of phosphoester thiol and relative reactant ratios. The resulting polymers transitioned from solid semicrystaline to liquid amorphous with increasing degree of phosphoester conjugation. Electrospun fibres from polymers with 14% phosphoester conjugation allowed attachment and survival of human dermal fibroblasts, indicating their biocompatibility. These polymers represent a new class of easily accessible biocompatible polyester-phosphoester hybrid materials as potential building blocks for tunable biomaterials

Cumulate causes for the low contents of sulfide-loving elements in the continental crust

Despite the economic importance of chalcophile (sulfide-loving) and siderophile (metal-loving) elements (CSEs), it is unclear how they become enriched or depleted in the continental crust, compared with the oceanic crust. This is due in part to our limited understanding of the partitioning behaviour of the CSEs. Here I compile compositional data for mid-ocean ridge basalts and subduction-related volcanic rocks. I show that the mantle-derived melts that contribute to oceanic and continental crust formation rarely avoid sulfide saturation during cooling in the crust and, on average, subduction-zone magmas fractionate sulfide at the base of the continental crust prior to ascent. Differentiation of mantle-derived melts enriches lower crustal sulfide- and silicate-bearing cumulates in some CSEs compared with the upper crust. This storage predisposes the cumulate-hosted compatible CSEs (such as Cu and Au) to be recycled back into the mantle during subduction and delamination, resulting in their low contents in the bulk continental crust and potentially contributing to the scarcity of ore deposits in the upper continental crust. By contrast, differentiation causes the upper oceanic and continental crust to become enriched in incompatible CSEs (such as W) compared with the lower oceanic and continental crust. Consequently, incompatible CSEs are predisposed to become enriched in subduction-zone magmas that contribute to continental crust formation and are less susceptible to removal from the continental crust via delamination compared with the compatible CSEs

A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil

<p>Abstract</p> <p>Background</p> <p>Ovarian cancer is sixth most common cancer among women and the leading cause of death in women with gynecological malignancies. Despite the great impact ovarian cancer has on women's health and its great impact in public economy, Brazil still lacks valuable information concerning epidemiological aspects of this disease</p> <p>Methods</p> <p>We've compiled clinical data of all ovarian tumors registered at the two public hospitals of reference (1997 - 2007), such as: patients' age at diagnosis, tumor histological type, tumor stage, chemotherapy regimens, chemotherapy responsiveness, disease-free survival, and overall survival.</p> <p>Results</p> <p>Women's mean age at diagnosis was 54.67 ± 13.84 for ovarian cancer, 46.15 ± 11.15 for borderline tumors, and 42.01 ± 15.06 for adenomas. Among epithelial ovarian cancer cases, 30.1% were of serous, 13.7% were of mucinous, and 13.7% were of endometrioid type; exceptionally serous carcinoma was diagnosed in women younger than 30 years old. Endometrioid cancer had lower disease-free survival than others (p < 0.05). Cases were predominantly diagnosed as poor prognosis disease (FIGO III and IV, 56.2%). Regarding responsiveness to platinum-based therapy, 17.1% of patients were resistant, whereas 24.6%, susceptible. From these, we found equally responsiveness to platinum alone or its association with paclitaxel or cyclophosphamide.</p> <p>Discussion</p> <p>Our data agreed with other studies regarding mean patients' age at diagnosis, histological type frequency, FIGO stages distribution, and chemotherapy regimens. However, the histological type distribution, with equal contribution of mucinous and endometrioid types seems to be a unique characteristic of the studied highly miscegenated population.</p> <p>Conclusion</p> <p>We have enlighten the profile of the studied ovarian cancer population, which might enable the development of more efficient political strategies to control this malignancy that is the fifth leading cause of cancer-related deaths among women.</p