Individuation and the organization in complex living ecosystem: recursive integration and self-assertion by holon-lymphocytes

International audienceIndividuation and organization in complex living multi-level ecosystem occurs as dynamical processes from early ontogeny. The notion of living “holon” displaying dynamic self-assertion and integration is used here to explain the ecosystems dynamic processes. The update of the living holon state according to the continuous change of the dynamic system allows for its viability. This is interpreted as adaptation, selection and organization by the human that observes the system at posteriori from its level. Our model concerns the complex dynamics of the adaptive immune system, integrating holon-lymphocytes that collectively preserve the identity and integrity of the organism. Each lymphocyte individualizes as a dynamic holon-lymphocyte, with somatic gene individuation leading to an individual, singular antigen immunoreceptor type, promoting the self-assertion. In turn, the “Immunoception” allows for perception of the environmental antigenic context, thus integration of the holon in its environment. The self-assertion/integration of holon-lymphocyte starts from fetal stages and is influenced by mother Lamarckian acquired historicity transmissions, a requisite for the integrity of the holobiont-organism. We propose a dynamic model of the perception by holon-lymphocyte, and at the supra-clonal level of the immune system functions that sustain the identity and integrity of the holon-holobiont organism

Immunodepression and Immunosuppression During Aging

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Modeling T lymphocyte dynamics: From physiology to perturbations of immune system

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Questionnements et connaissance de la complexité

International audienceBiologiste, titulaire d'un Doctorat en Immunologie de l'Université Pierre et Marie Curie, je suis chercheur au Centre National de la Recherche Scientifique. Après un parcours de recherches scientifiques et d'expérimentation sur la physiologie du système immunitaire, j'ai orienté mes recherches vers la compréhension de la complexité des systèmes, en particulier pour aborder l'organisation et désorganisation du système immunitaire à travers le temps, de l'ontogénie au vieillissement et les effets de perturbations. J'ai créé le réseau ImmunoComplexiT qui réunit une communauté de chercheurs interdisciplinaires pour aborder la complexité du système immunitaire. Ceci m'amène à repenser comment je perçois la science aujourd'hui, et les orientations qui sont actuellement prises