Spectrum of Gastroenteropancreatic NENs in Routine Histological Examinations of Bioptic and Surgical Specimen: A Study of 161 Cases Collected from 17 Departments of Pathology in the Czech Republic

Objective. To characterize GEP-NENs in routine biopsies and surgical specimen in the Czech Republic and to evaluate how WHO Classification (2010) is acceptable in diagnostic practice. Methods. Paraffin-embedded blocks and bioptic reports were collected from 17 departments of pathology. Histologic slides were stained with H&E and immunohistologically for CgA, synaptophysin, and Ki-67. Results. Out of 28 gastric NENs, there were 22 NETs, G1, 5 NETs, G2, and 1 NEC. Ten duodenal NENs were NETs, G1. Among 27 NENs of jejunum and ileum, 23 were NETs, G1, 2 NETs, G2, and 1 NEC and 1 mixed adenoneuroendocrine carcinoma (MANEC). Among 42 appendiceal “incidentalomas”, 39 were NETs G1, 2 goblet cell carcinoids, and 1 MANEC. Out of 34 large intestinal NENs, 30 were NETs, G1, 3 NETs, G2, and 1 NEC. One small intestinal and 6 large bowel neoplasms were reclassified as poorly differentiated adenocarcinomas. In 12 pancreatic NENs, there were 7 NETs, G1, 3 NETs, G2, and 2 NECs. Conclusions. Our study demonstrates differences in GEP-NENs frequency in sites of origin in our region, comparing to other countries. Regarding routine bioptic diagnostics, we gave evidence that the WHO 2010 classification of NENs is fully acceptable for exact categorisation of tumours

Návod, jak vyučovati písmu latinskému, italskému, okrouhlému, německému a gotickému

monografi

Steel structure of lookout tower

The diploma thesis deals with the design of a main load-bearing steel structure of the lookout tower with the height 35,5 m. Two different types of solution were designed. The first design is a spacial truss structure and the second design is a fixed solid cantilever. The first solution was chosen to be further developed. The truss structure has square plan that varies with height. The width is 6,6 m in the level of supports and 3,6 m in the narrowest section. Main bearing members are five pin-supported columns. The base material is steel of class S355

Steel structure of industrial hall

The bachelor thesis deals with the design of a main load-bearing steel structure of industrial hall with two overhead cranes. The floor plan dimensions are 24 × 60 m, height of building is 16 m. The main structure consists of pin-supported symetrical truss girders on columns with centre to centre spacing 12 m. The truss purlins are pin-supported on the girders. The columns are fixed in the lateral direction. Spatial rigidity of the structure is secured by system of bracing. The base material is steel of class S355

Steel structure of industrial hall

The bachelor thesis deals with the design of a main load-bearing steel structure of industrial hall with two overhead cranes. The floor plan dimensions are 24 × 60 m, height of building is 16 m. The main structure consists of pin-supported symetrical truss girders on columns with centre to centre spacing 12 m. The truss purlins are pin-supported on the girders. The columns are fixed in the lateral direction. Spatial rigidity of the structure is secured by system of bracing. The base material is steel of class S355