Down Regulation of Plasma and Tissue Biomarkers by Homocastasterone

Homocastasterone is a ketosteroid and a member of the brassinosteroid family of plant hormones. Earlier studies with 28-homobrasslinolide, an aldosteroid, had indicated that rat blood and tissue biochemical parameters studied were affected by this compound, resulting in altered homeostasis and cellular phosphorylation status, rendering this plant oxysterol inappropriate for high energy related work activities. The use of the ketosteroid in this study presents evidence for renormalization of elevated plasma lipid content in diabetic rat, antiglycemic potency, increase in liver glycogen and glucose level and diminished ALT and AST enzyme activities. A role for this ketosteroid in rat liver gluconeogenesis and in lipid homeostasis is suggested while the aldo and keto forms regulated glucose homeostasis in the rat. The observed differences in the effects of homobrasslinolide and homocastasterone as exogenous oxysterols on normal and diabetic rat plasma lipid level suggests the possibility of differential influence by endogenous aldo and keto oxycholesterol forms on glucose and lipid homeostasis in mammalian physiology

Bioconversion efficiency and growth in the white shrimp Penaeus indicus (Milne Edwards), fed with decomposed mangrove leaves

Food conversion efficiency and growth in the white shrimp Penaeus indicus fed with decomposed mangrove leaves of Avicennia marina and A. officinalis were monitored under laboratory conditions. It was observed that test animals fed with the decomposed leaves of A. marina had higher assimilation efficiency (87.96%), gross growth efficiency (10.82%), net growth efficiency (12.3%) and relative growth rate (0.0603 g/day) than those fed with A. officinalis. The relatively higher growth registered in the animals fed with decomposed leaves of A. marina was attributed to its high calorific and protein content

HOMOCASTASTERONE: A NOVEL PLANT KETOSTEROID INDUCING HAEMATOLOGICAL CHANGES IN NORMAL AND DIABETIC MALE RAT

Objective: To study the effect of brassinosteroid keto isoform homocastasterone, in diabetic male wistar rat as an antihyperglycemic factor and to evaluate its effects on the hemodynamic parameters in rat blood.Methods: Diabetes was induced in a group (n=6) of rats with a single peritoneal injection of streptozotocin at 60 mg/kg. bw. With a treatment schedule of 15 consecutive days, control (n=6) and diabetic rats received 666µg/kg bw, of homocastasterone. Circulating blood glucose, cell count, cell indices, and MDA level was assessed.Results: Significant reduction (p<0.05) in blood glucose level and increase inRBCs, WBCs, granulocytes, lymphocytes, monocytes and platelets count(p<0.05) along with improved functional indices for HCT, PCV, MCV, MCH, MCHC, MPV, PDW, PCT in homocastasterone treated diabetic group was noted. A significant reduction in RBC-MDA level (p<0.001) in the treated group was noted.Conclusion: It is suggested that brassinosteroid keto isoform homocastasterone exhibits antiglycemic effect in diabetic rat, and improves RBC, WBC, Platelet counts, haemoglobin level, and cell indices, while reducing peroxidative cell damage in RBCs.Â

Down Regulation of Plasma and Tissue Biomarkers by Homocastasterone

Homocastasterone is a ketosteroid and a member of the brassinosteroid family of plant hormones. Earlier studies with 28-homobrasslinolide, an aldosteroid, had indicated that rat blood and tissue biochemical parameters studied were affected by this compound, resulting in altered homeostasis and cellular phosphorylation status, rendering this plant oxysterol inappropriate for high energy related work activities. The use of the ketosteroid in this study presents evidence for renormalization of elevated plasma lipid content in diabetic rat, antiglycemic potency, increase in liver glycogen and glucose level and diminished ALT and AST enzyme activities. A role for this ketosteroid in rat liver gluconeogenesis and in lipid homeostasis is suggested while the aldo and keto forms regulated glucose homeostasis in the rat. The observed differences in the effects of homobrasslinolide and homocastasterone as exogenous oxysterols on normal and diabetic rat plasma lipid level suggests the possibility of differential influence by endogenous aldo and keto oxycholesterol forms on glucose and lipid homeostasis in mammalian physiology

Studies on Composite Extrudable Propellant with varied Burning Rate Pressure Index 'n'

This paper discusses the development of composite propellantextrusion technique and the study of burning rate pressure indices nwith respect to compositional variations. The n is found to vary from0.35 to plateau and plateau to mesa by suitable compositionalmodifications. Compositional influence on burning rate with specificreference to plateau and mesaburning additives is described. Detailsof the process parameters like fluidity of the slurry, extrusion pressure,extrusion rate and die-swell are presented. This propellant is based onISRO-CTPB binder using ISRO-AP as oxidizer. Ammonium perchlorate (AP) particle size variation and inclusion of additives likePVC, lead stearate, ammonium sulphate, lithium fluoride etc. are foundto influence the burning rate pressure index n

Data repository

All the research data were taken from the established journals which is available online.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Routing Protocol Enhancement for handling Node Mobility in Wireless Sensor Networks

In wireless sensor networks, the routing algorithms currently available assume that the sensor nodes are stationary. Therefore when mobility modulation is applied to the wireless sensor networks, most of the current routing algorithms suffer from performance degradation. The path breaks in mobile wireless networks are due to the movement of mobile nodes, node failure, channel fading and shadowing. It is desirable to deal with dynamic topology changes with optimal effort in terms of resource and channel utilization. As the nodes in wireless sensor medium make use of wireless broadcast to communicate, it is possible to make use of neighboring node information to recover from path failure. Cooperation among the neighboring nodes plays an important role in the context of routing among the mobile nodes. This paper proposes an enhancement to an existing protocol for accommodating node mobility through neighboring node information while keeping the utilization of resources to a minimum.Cochin University of Science and Technolog

Routing Protocol Enhancement for handling Node Mobility in Wireless Sensor Networks

In wireless sensor networks, the routing algorithms currently available assume that the sensor nodes are stationary. Therefore when mobility modulation is applied to the wireless sensor networks, most of the current routing algorithms suffer from performance degradation. The path breaks in mobile wireless networks are due to the movement of mobile nodes, node failure, channel fading and shadowing. It is desirable to deal with dynamic topology changes with optimal effort in terms of resource and channel utilization. As the nodes in wireless sensor medium make use of wireless broadcast to communicate, it is possible to make use of neighboring node information to recover from path failure. Cooperation among the neighboring nodes plays an important role in the context of routing among the mobile nodes. This paper proposes an enhancement to an existing protocol for accommodating node mobility through neighboring node information while keeping the utilization of resources to a minimum.Cochin University of Science and TechnologyTENCON 2008-2008 IEEE Region 10 Conferenc

Microbiological evaluation of UV disinfection effectiveness in a specialist cystic fibrosis clinic.

The aim of the study was to evaluate the impact of manual cleaning and manual cleaning followed by Ultraviolet-C disinfection on the colony forming units of bacteria retrievable from equipment and surfaces within clinic rooms following a CF outpatient encounter. While UV disinfection has proven to be effective within general healthcare settings, it has not been evaluated in a CF centre. Microbiological sampling was performed following outpatient encounters involving 11 adult patients with CF and chronic infection with P.aeruginosa, MRSA or E. coli ESBL. The results of this study suggest that manual cleaning followed by UV-C disinfection is more effective than manual cleaning alone at reducing environmental contamination within a CF clinic and that UV-C isinfection is likely to reduce the risk of fomite transmission in the CF outpatient setting