4-Hydroxy­benzohydrazide

In the title compound, C7H8N2O2, the mean planes of the benzene ring and the planar hydrazide group are inclined at 25.75 (6)° with respect to each other. The structure is stabilized by inter­molecular N—H⋯O and O—H⋯N hydrogen bonds

3-Chloro­benzohydrazide

In the title compound, C7H7ClN2O, the hydrazide group is inclined at a dihedral angle of 32.30 (11)° with respect to the benzene ring. The amino H atoms form inter­molecular N—H⋯O hydrogen bonds with the O atoms of two adjacent mol­ecules, resulting in 10-membered rings of graph-set motif R 2 2(10). The imino H atom is also involved in an inter­molecular hydrogen bond with an amino N atom of a symmetry-related mol­ecule, resulting in a zigzag chain along the b axis. The structure is further consolidated by an intra­molecular N—H⋯O inter­action, which results in a five-membered ring

4-Methoxy­benzohydrazide

The title compound, C8H10N2O2, is stabilized by three inter­molecular hydrogen bonds of the N—H⋯O and N—H⋯N types. Two intra­molecular inter­actions of the N—H⋯O and C—H⋯O types are also observed

3-Amino-N′-(2-oxoindolin-3-yl­idene)benzohydrazide

The title compound, C15H12N4O2, contains two substituted benzohydrazide and indole rings linked via a C=N double bond. The dihedral angle between the benzene ring and the indole ring system is 11.38 (10)°. The mol­ecular structure is stabilized by an intra­molecular N—H⋯O hydrogen bond, forming a six-membered ring. The crystal structure is consolidated by inter­molecular N—H⋯O and C—H⋯O inter­actions, which result in sheets

Alpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes

This study focused on the synthesis and characterization of hydrazide ligands and their respective Pd(II) complexes and used high throughput screening to determine their α-glucosidase and carbonic anhydrase II enzyme inhibition activities. The physical, analytical (elemental analyses for C, H, N and Pd) and spectral (FT-IR, 1H NMR, 13C NMR, EI-mass) techniques utilized during characterization revealed the formation of square planar, neutral and 1:2 Pd(II)-hydrazide complexes with the general formula [PdL2Cl2]. In these Pd(II) complexes, the hydrazide ligands are monodentate; the terminal nitrogen is the donor atom. The uncoordinated hydrazide ligands were inactive against both α-glucosidase and carbonic anhydrase II enzymes; however, the respective Pd(II)-hydrazide complexes were approximately 300 times more potent α-glucosidase inhibitors than the standard compound, 1-deoxynojirimycin (DNJ). Some of the Pd(II) complexes also demonstrated potential carbonic anhydrase (CA) inhibition properties comparable to the standard compound, acetazolamide (ACZ).Higher Education Commission of Pakistan for financial support (‘The National Research Grants Program for Universities’, grant No.1862/R&D/10) and MMT acknowledges the support from Fulbright Scholar Award from The J. William Fulbright Foreign Scholarship Board. Open Access funded by King Saud University

4-Phenyl­semicarbazide

The title compound, C7H9N3O, crystallizes with two independent mol­ecules per asymmetric unit. The structure is stabilized by four distinct inter­molecular N—H⋯O hydrogen bonds. Four intra­molecular inter­actions of the N—H⋯N and C—H⋯O types are also observed

(3Z)-3-Hydrazinylideneindolin-2-one

The title mol­ecule, C8H7N3O, is almost planar, with a maximum deviation of 0.0232 (2) Å from the least-squares plane. The Z conformation of the C=N double bond is stabilized by an intra­molecular N—H⋯O hydrogen bond. In the crystal, adjacent mol­ecules are linked by inter­molecular N—H⋯N and N—H⋯O hydrogen bonds, forming zigzag sheets parallel to the c axis; the sheets are further stabilized by π–π inter­actions [centroid–centroid distance = 3.7390 (10) Å]

4-Iodo­benzohydrazide

In the structure of the title compound, C7H7IN2O, the hydrazide group is inclined at 13.3 (3)° with respect to the benzene ring. The structure is stabilized by inter­molecular N—H⋯N and N—H⋯O hydrogen bonds involving the hydrazide group, resulting in six- and ten-membered rings with R 2 2(6) and R 2 2(10) graph-set notations, respectively

3,4,5-Trihy­droxy­benzohydrazide

In the title compound, C7H8N2O4, the dihedral angle between the aromatic ring and the hydrazide grouping is 21.34 (7)°. In the crystal, the mol­ecules are linked into a three-dimensional network by O—H⋯O, O—H⋯N and N—H⋯O hydrogen bonds

2-Methoxy­benzohydrazide

The title compound, C8H10N2O2, crystallizes as two independent mol­ecules linked by N—H⋯N and N—H⋯O hydrogen bonds into a linear chain running along the a axis of the monoclinic unit cell. The intra- and inter­molecular hydrogen bonds are described as a two-ring R 2 2(10) motif. The six-membered R 1 1(6) rings formed by the intra­molecular inter­actions are almost planar (r.m.s. deviations 0.06 and 0.08 Å). In one mol­ecule, the aromatic and hydrogen-bonded rings are oriented at 4.8 (2)°, whereas in the other mol­ecule these rings are oriented at 6.1 (4)°