Demographic characteristics of patients with suspected or confirmed typhoid fever, Kasese and Bundibugyo districts, Uganda, August 1, 2009–December 31, 2011.

<p>*Includes 12 patients for whom intestinal perforation status was reported by clinician as “don't know”.</p><p>**Includes 7 patients for whom intestinal perforation status was reported by clinician as “don't know” and 33 patients for whom intestinal perforation status could not be determined from district linelist.</p>†<p>For some items, n may vary by small numbers due to “don't know” or missing responses.</p>‡<p>Wilcoxon rank-sum test (median age) or Fisher's exact test (gender) for difference between Kasese patients with and without intestinal perforation.</p>‡‡<p>Wilcoxon rank-sum test (median age) or Fisher's exact test (gender) for difference between Bundibugyo patients with and without intestinal perforation.</p>a<p>Median age different by gender among all Kasese patients (<i>P</i> = 0.002) and among patients with intestinal perforation from Kasese (<i>P</i> = 0.0004) and Bundibugyo (<i>P</i> = 0.03). Median age did not differ significantly by gender among patients without intestinal perforation in either district.</p

Clinical history of typhoid fever patients, Kasese and Bundibugyo Districts, April 15, 2011–January 6, 2012.

†<p>For some items, n may vary by small numbers due to “don't know” responses.</p><p>*Percentage totals may be >100%; respondents could select ≥1 source of care and antibiotic.</p>‡<p>Kasese patients: 1 school nurse; Bundibugyo patients: 5 friend or relative.</p>‡‡<p>Kasese patients: 1 each cephalexin, erythromycin, gentamycin, 4 unknown; Bundibugyo patients: 1 each ceftriaxone and doxycycline, 2 unknown.</p

Clinical features^*of typhoid fever patients reported on case report forms, Kasese and Bundibugyo Districts, April 15, 2011–December 31, 2011.

<p>*Case definition specified that fever and abdominal pain must be present.</p>†<p>For some items, n may vary by small numbers due to “don't know” responses.</p

Diversity of PFGE patterns among <i>Salmonella</i> Typhi isolated from Kasese and Bundibugyo patients.

<p>Each <i>Xba</i>I/<i>Bln</i>I PFGE pattern combination is represented by a different shading; pattern combinations designated by letter are shared across districts and/or years. <i>Salmonella</i> Typhi isolated from October 18–December 31, 2011 were from 13 Bundibugyo and 5 Kasese patients; among these, we observed 6 and 4 pattern combinations, respectively. Investigations in Kasese from March 4–April 17, 2009 yielded 33 <i>Salmonella</i> Typhi isolates, among these 13 pattern combinations were identified <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002726#pntd.0002726-Neil1" target="_blank">[6]</a>.</p

Cases of typhoid fever in Bundibugyo, by age, gender, and intestinal perforation status.

<p>January 1–December 31, 2011, n = 244 with known age, sex, and intestinal perforation status, *<i>P</i> = 0.03 and **<i>P</i> = 0.0006.</p

Selected characteristics of patients with suspected typhoid fever, by intestinal perforation (IP) status, April 15, 2011–January 6, 2012.

<p>*For some items, n may vary by small numbers due to “don't know” responses.</p><p>**Fisher's Exact test.</p>†<p>Percentage totals may be >100%; respondents could select ≥1 source of care and antibiotic.</p>‡<p>Patients with intestinal perforation: 1 each ceftriaxone, gentamycin, and unspecified; patients without intestinal perforation: 1 each cephalexin, doxycycline, erythromycin, and gentamycin, and 5 unspecified.</p