Poly–adenosine diphosphate–ribose polymerase inhibition for myocardial protection: Pathophysiologic and physiologic considerations

Plantilles de l’Institut Barcelona Esports, de l’Institut Municipal del Paisatge Urbà i la Qualitat de Vida, de l’Institut Municipal d'Informàtica, de l’Institut Municipal d'Hisenda, de l’Institut Municipal d'Educació, de l’Institut Municipal de Mercats, de l’Institut Municipal de Serveis Socials i de l’Institut Municipal de Persones amb Discapacita

Failure of Autologous Fresh Frozen Plasma to Reduce Blood Loss and Transfusion Requirements in Coronary Artery Bypass Surgery

Background: Previous studies failed to demonstrate any benefit from prophylaxis with fresh frozen plasma (FFP) after cardiopulmonary bypass (CPB). The results, however, were limited by either retrospective study design or use of FFP in subtherapeutic doses (2-3 units). The authors evaluated whether a therapeutic dose (15 ml/kg) of FFP reduces blood loss and transfusion requirements in elective coronary artery bypass surgery. The risks of multiple allogeneic blood donor exposure were circumvented by using autologous plasma. Methods: Sixty adult patients scheduled for elective primary coronary artery bypass grafting were randomized to receive, after CPB, an intravenous infusion of 15 ml/kg of either autologous FFP (30 patients) or 6% hydroxyethyl starch 450/0.7 (HES; 30 patients). Autologous plasma was obtained by plateletpoor plasmapheresis several weeks before surgery. Perioperative blood transfusions were administered per protocol. Postoperative blood loss was defined as the chest tube drainage during the first 24 h after surgery. Results: The data from 56 patients (FFP group, 27 patients; HES group, 29 patients) who completed the study according to protocol were analyzed. Median postoperative blood loss was 630 ml (range, 450 -1,840 ml) and 830 ml (range, 340 -1,980 ml) in the FFP and HES groups, respectively (P ‫؍‬ 0.08). Both postoperative (0 -24 h) and total perioperative erythrocyte transfusion requirements did not differ significantly between the groups (P ‫؍‬ 0.32 and 0.14, respectively). Conclusion: The prophylactic administration of a therapeutic dose (15 ml/kg) of autologous FFP after CPB failed to reduce blood loss and transfusion requirements in patients undergoing uncomplicated, elective, primary coronary artery bypass surgery

IDPredictor: predict database links in biomedical database

Knowledge found in biomedical databases, in particular in Web information systems, is a major bioinformatics resource. In general, this biological knowledge is worldwide represented in a network of databases. These data is spread among thousands of databases, which overlap in content, but differ substantially with respect to content detail, interface, formats and data structure

IDPredictor : predict database links in biomedical database

Knowledge found in biomedical databases, in particular in Web information systems, is a major bioinformatics resource. In general, this biological knowledge is worldwide represented in a network of databases. These data is spread among thousands of databases, which overlap in content, but differ substantially with respect to content detail, interface, formats and data structure. To support a functional annotation of lab data, such as protein sequences, metabolites or DNA sequences as well as a semi-automated data exploration in information retrieval environments, an integrated view to databases is essential. Search engines have the potential of assisting in data retrieval from these structured sources, but fall short of providing a comprehensive knowledge except out of the interlinked databases. A prerequisite of supporting the concept of an integrated data view is to acquire insights into cross-references among database entities. This issue is being hampered by the fact, that only a fraction of all possible cross-references are explicitely tagged in the particular biomedical informations systems. In this work, we investigate to what extend an automated construction of an integrated data network is possible. We propose a method that predicts and extracts cross-references from multiple life science databases and possible referenced data targets. We study the retrieval quality of our method and report on first, promising results. The method is implemented as the tool IDPredictor, which is published under the DOI 10.5447/IPK/2012/4 and is freely available using the URL: http://dx.doi.org/10.5447/IPK/2012/4.publishe

Inhalte zur Entwicklung landeskundlicher und interkultureller Kompetenzen

Koreik U. Inhalte zur Entwicklung landeskundlicher und interkultureller Kompetenzen. In: Burwitz-Melzer E, Mehlhorn G, Riemer C, BAusch K-R, Krumm H-J, eds. Handbuch Fremdsprachenunterricht. 6 völlig überarbeitete und erweiterte Auflage. Tübingen: Francke; 2016: 163-167